25-Hydroxyvitamin D status is associated with interleukin-6 methylation in adipose tissue from patients with colorectal cancer

2021 ◽  
Author(s):  
Hatim Boughanem ◽  
Patricia Ruiz-Limon ◽  
Ana B. Crujeiras ◽  
Vanessa de Luque ◽  
Francisco J. Tinahones ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Proinflammatory Cytokines ◽  
Interleukin 6 ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Visceral Adipose

A dysfunctional visceral adipose tissue (VAT) is characterized by increased production of proinflammatory cytokines, which may increase the risk of colorectal cancer (CRC).

scholarly journals Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel Castellano-Castillo ◽  
Sonsoles Morcillo ◽  
Ana B. Crujeiras ◽  
Lidia Sánchez-Alcoholado ◽  
Mercedes Clemente-Postigo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Global Dna Methylation ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Colorectal Cancer Patients ◽  
Visceral Adipose

scholarly journals Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer

2017 ◽  
Vol 8 ◽  
Author(s):  
Gloria Donninelli ◽  
Manuela Del Cornò ◽  
Marina Pierdominici ◽  
Beatrice Scazzocchio ◽  
Rosaria Varì ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
T Cell ◽  
Visceral Adipose Tissue ◽  
Regulatory T Cell ◽  
Visceral Adipose

Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity

2019 ◽  
Vol 59 (4) ◽  
pp. 1463-1472 ◽  
Author(s):  
B. Scazzocchio ◽  
R. Varì ◽  
A. Silenzi ◽  
S. Giammarioli ◽  
A. Masotti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Visceral Adipose Tissue ◽  
Dietary Habits ◽  
Visceral Adipose

scholarly journals Compounds of psoriasis with obesity and overweight

2017 ◽  
Vol 71 (1) ◽  
pp. 0-0
Author(s):  
Agnieszka Owczarczyk-Saczonek ◽  
Waldemar Placek
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Inflammatory Cytokines ◽  
Visceral Adipose Tissue ◽  
Proinflammatory Cytokines ◽  
Systemic Disease ◽  
Retinol Binding Protein ◽  
Special Role ◽  
Alcoholic Fatty Liver ◽  
Visceral Adipose

Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases. Macrophages of visceral adipose tissue have a special role and they increase significantly in obesity. They are responsible for the development of inflammation in adipose tissue and produce inflammatory cytokines (TNF alpha, IL-6, Il-8, Il-17, Il-18, MCP-1) and other adipokines: resistin, visfatin, retinol-binding protein 4. This explains the concept of «psoriatic march «and observations of the frequent coexistence of psoriasis with obesity. Inflammation associated with systemic disease, fanned by pro-inflammatory cytokines and adipokines produced by the visceral adipose tissue lead to the development of insulin resistance, endothelial cell damage. Endothelial dysfunction predisposes to the formation of atherosclerotic plaques and faster development of cardiovascular events. Complication of obesity is the development of non-alcoholic fatty liver disease (NAFLD), which states twice as likely in patients with plaque psoriasis and is associated with the severity of the disease. Another consequence is the development of depression. Probably the proinflammatory cytokines can interact with metabolism of neurotransmitters. Obesity also has a significant impact on the treatment of psoriasis, increasing the risk of adverse effects of systemic drugs, reducing the efficacy of biological agents which dose should be adjusted to the weight of the patient. It is a factor responsible for the increased volume of distribution and it causes low titter of drug concentration.

623 Visceral Adipose Tissue Changes After Surgery in Colorectal Cancer Patients May Have Prognostic Implications

2014 ◽  
Vol 146 (5) ◽  
pp. S-1023-S-1024
Author(s):  
Eun Kyung Choe ◽  
Heung-Kwon Oh ◽  
Sang Hui Moon ◽  
Seung-Bum Ryoo ◽  
Kyu Joo Park
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Tissue Changes ◽  
Prognostic Implications ◽  
Colorectal Cancer Patients ◽  
Visceral Adipose

scholarly journals Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Hoon Lee ◽  
Soyoung Kim ◽  
Hye Sun Lee ◽  
Eun Jung Park ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Glucose Uptake ◽  
Visceral Adipose Tissue ◽  
Visceral Fat ◽  
Male And Female ◽  
Female Patients ◽  
Pet Ct ◽  
Visceral Adipose ◽  
Fat Volume

AbstractThe purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.

scholarly journals The Association of Abdominal Adiposity With Mortality in Patients With Stage I–III Colorectal Cancer

2019 ◽  
Vol 112 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Justin C Brown ◽  
Bette J Caan ◽  
Carla M Prado ◽  
Elizabeth M Cespedes Feliciano ◽  
Jingjie Xiao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Colorectal Cancer Patients ◽  
Subcutaneous Adiposity ◽  
Visceral Adipose ◽  
Subcutaneous Adipose ◽  
Shaped Pattern

Abstract Background The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients, and such associations may vary by patient sex. Methods This cohort included 3262 stage I–III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values. Results Visceral adipose tissue was prognostic of mortality in a reverse L-shaped pattern (nonlinear P = .02); risk was flat to a threshold (∼260 cm2) then increased linearly. Subcutaneous adipose tissue was prognostic of mortality in a J-shaped pattern (nonlinear P &lt; .001); risk was higher at extreme (&lt;50 cm2) but lower at intermediate values (&gt;50 to ≤560 cm2). Patient sex modified the prognostic associations between visceral adipose tissue (Pinteraction = .049) and subcutaneous adipose tissue (Pinteraction = .04) with mortality. Among men, visceral adiposity was associated with mortality in a J-shaped pattern (nonlinear P = .003), whereas among women, visceral adiposity was associated with mortality in a linear pattern (linear P = .008). Among men, subcutaneous adiposity was associated with mortality in an L-shaped pattern (nonlinear P = .01), whereas among women, subcutaneous adiposity was associated with mortality in a J-shaped pattern (nonlinear P &lt; .001). Conclusions Visceral and subcutaneous adipose tissue were prognostic of mortality in patients with colorectal cancer; the shape of these associations were often nonlinear and varied by patient sex. These results offer insight into the potential biological mechanisms that link obesity with clinical outcomes in patients with cancer, suggesting that the dysregulated deposition of excess adiposity is prognostic of mortality.

The impact of visceral adipose tissue amount on the adequacy of lymph node retrieval in colorectal cancer surgery

2017 ◽  
Vol 117 (3) ◽  
pp. 523-528 ◽  
Author(s):  
Eun Kyung Choe ◽  
Kyu Joo Park ◽  
Seung-Bum Ryoo ◽  
Sang Hui Moon ◽  
Heung-Kwon Oh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Lymph Node ◽  
Visceral Adipose Tissue ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Lymph Node Retrieval ◽  
Visceral Adipose ◽  
The Impact

DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer

Epigenetics ◽  
2021 ◽  
pp. 1-12
Author(s):  
Andrea G Izquierdo ◽  
Hatim Boughanem ◽  
Angel Diaz-Lagares ◽  
Isabel Arranz-Salas ◽  
Manel Esteller ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Dna Methylome ◽  
Visceral Adipose
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