scholarly journals Increased peroxisome proliferator-activated receptor γ expression levels in visceral adipose tissue, and serum CCL2 and interleukin-6 levels during visceral adipose tissue accumulation

2014 ◽  
Vol 11 (1) ◽  
pp. 515-520 ◽  
Author(s):  
THANESWARY YOGARAJAH ◽  
YVONNE-TEE GET BEE ◽  
RAHMAH NOORDIN ◽  
KHOO BOON YIN
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Interleukin 6 ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Expression Levels ◽  
Tissue Accumulation ◽  
Visceral Adipose

scholarly journals PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

2021 ◽  
Vol 118 (13) ◽  
pp. e2025197118
Author(s):  
Chaoran Li ◽  
Andrés R. Muñoz-Rojas ◽  
Gang Wang ◽  
Alexander O. Mann ◽  
Christophe Benoist ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Single Cell ◽  
Visceral Adipose Tissue ◽  
Cell Receptor ◽  
Lymphoid Tissues ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Treg Population ◽  
Nonlymphoid Tissue ◽  
Visceral Adipose

Foxp3+CD4+ regulatory T cells (Tregs) regulate most types of immune response as well as several processes important for tissue homeostasis, for example, metabolism and repair. Dedicated Treg compartments—with distinct transcriptomes, T cell receptor repertoires, and growth/survival factor dependencies—have been identified in several nonlymphoid tissues. These Tregs are specifically adapted to function and operate in their home tissue—When, where, and how do they take on their specialized characteristics? We recently reported that a splenic Treg population expressing low levels of the transcription factor PPARγ (peroxisome proliferator-activated receptor gamma) contains precursors of Tregs residing in visceral adipose tissue. This finding made sense given that PPARγ, the “master regulator” of adipocyte differentiation, is required for the accumulation and function of Tregs in visceral adipose tissue but not in lymphoid tissues. Here we use single-cell RNA sequencing, single-cell Tcra and Tcrb sequencing, and adoptive-transfer experiments to show that, unexpectedly, the splenic PPARγlo Treg population is transcriptionally heterogeneous and engenders Tregs in multiple nonlymphoid tissues beyond visceral adipose tissue, such as skin and liver. The existence of a general pool of splenic precursors for nonlymphoid-tissue Tregs opens possibilities for regulating their emergence experimentally or therapeutically.

scholarly journals Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet

2020 ◽  
Vol 10 (2) ◽  
pp. 106-117
Author(s):  
Maryam Mostafavian ◽  
◽  
Ahmad Abdi ◽  
Javad Mehrabani ◽  
Alireza Barari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
High Fat Diet ◽  
Uncoupling Protein ◽  
Normal Diet ◽  
Peroxisome Proliferator ◽  
High Fat ◽  
Peroxisome Proliferator Activated Receptor ◽  
Visceral Adipose

Objective: Decreased physical activity coupled with increased High‐Fat Diet (HFD) intake prompts obesity. Current research suggests that changing White Adipose Tissue (WAT) to brown promotes energy expenditure to counter obesity. The purpose of this study was to investigate the effects of aerobic Progressive training and Capsaicin (Cap) on Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and Uncoupling protein-1 (UPC-1) gene expression in rat fed a high-fat diet. Methods: 40 male Wistar rats aged 8-12 weeks, were fed a Normal Diet (ND) (n=8) or HFD (n=32) for 8 weeks. After 8 weeks, rats were divided into 5 groups: ND, HFD, High-Fat Diet-Training (HFDT), High-Fat Diet-Capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups have performed a progressive aerobic running program on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) were administered orally, by gavage, once a day. PGC-1α and UCP-1 gene expression levels in the VAT were measured by Real-time PCR method. Results: The results of this study showed that PGC-1α and UCP-expression was decreased in HFD group compared to ND group. Also, the expression of PGC-1α and UPC-1 in HFDT, HFDCap and HFDTCap groups was significantly increased compared to HFD. The expression of PGC-1α and UPC-1 in HFDTCap was also significantly increased compared to HFDT and HFDCap groups. Conclusion: Possibly, eight weeks of progressive training combined with capsaicin administration has an effect on the browning of visceral adipose tissue in HFD rats by increasing expression of PGC-1α and UCP-1.

scholarly journals The Expression/Methylation Profile of Adipogenic and Inflammatory Transcription Factors in Adipose Tissue Are Linked to Obesity-Related Colorectal Cancer

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1629 ◽  
Author(s):  
Hatim Boughanem ◽  
Amanda Cabrera-Mulero ◽  
Pablo Hernández-Alonso ◽  
Borja Bandera-Merchán ◽  
Alberto Tinahones ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Transcription Factors ◽  
Visceral Adipose Tissue ◽  
Critical Role ◽  
Colorectal Carcinogenesis ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Obese Control ◽  
Visceral Adipose

Obesity is well accepted as crucial risk factor that plays a critical role in the initiation and progression of colorectal cancer (CRC). More specifically, visceral adipose tissue (VAT) in people with obesity could produce chronic inflammation and an altered profile expression of key transcription factors that promote a favorable microenvironment to colorectal carcinogenesis. For this, the aim of this study was to explore the relationship between adipogenic and inflammatory transcription factors in VAT from nonobese, obese, and/or CRC patients. To test this idea, we studied the expression and methylation of CCAAT-enhancer binding protein type alpha (C/EBP-α), peroxisome proliferator-activated receptor gamma (PPAR-γ), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) in VAT from non-obese control, non-obese CRC subjects, overweight/obese control, and overweight/obese CRC patients and their correlation with anthropometric and biochemical variables. We found decreased expression of C/EBP-α in overweight/obese CRC patients in comparison with overweight/obese control subjects. PGC-1α and NF-κB were overexpressed in CRC patients independently of the BMI. NF-κB promoter was hypomethylated in overweight/obese CRC patients when compared to overweight/obese control individuals. In addition, multiple significant correlations between expression, methylation, and biochemical parameters were found. Finally, linear regression analysis showed that the expression of C/EBP-α and NF-κB and that NF-κB methylation were associated with CRC and able to explain up to 55% of CRC variability. Our results suggest that visceral adipose tissue may be a key factor in tumor development and inflammatory state. We propose C/EBP-α, PGC-1α and NF-κB to be interesting candidates as potential biomarkers in adipose tissue for CRC patients.

scholarly journals Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Zhang ◽  
Zhiwei Zhang ◽  
Yulei Ding ◽  
Peng Xu ◽  
Tingting Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Adipose Tissue ◽  
Blood Glucose ◽  
Visceral Adipose Tissue ◽  
Tissue Expression ◽  
Normal Group ◽  
Expression Levels ◽  
Visceral Adipose ◽  
Male Subjects ◽  
Female Subjects

Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels ofTBX1andTCF21were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P<0.01). The visceral adipose tissue expression levels ofAPNin normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels ofTNF-αandMCP-1in normal group were lower than those in obesity and T2DM groups (P<0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.

Effects of Growth Hormone on Abnormal Visceral Adipose Tissue Accumulation and Dyslipidemia in HIV-Infected Patients

2004 ◽  
Vol 35 (3) ◽  
pp. 239-252 ◽  
Author(s):  
Donald P. Kotler ◽  
Norma Muurahainen ◽  
Carl Grunfeld ◽  
Christine Wanke ◽  
Melanie Thompson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Tissue Accumulation ◽  
Visceral Adipose

Visceral adipose tissue accumulation, secretory phospholipase A2-IIA and atherogenecity of LDL

2006 ◽  
Vol 30 (11) ◽  
pp. 1615-1622 ◽  
Author(s):  
M-E Paradis ◽  
M-O Hogue ◽  
J-F Mauger ◽  
C Couillard ◽  
P Couture ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Phospholipase A2 ◽  
Visceral Adipose Tissue ◽  
Secretory Phospholipase A2 ◽  
Tissue Accumulation ◽  
Secretory Phospholipase ◽  
Visceral Adipose
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