scholarly journals Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer

2017 ◽  
Vol 8 ◽  
Author(s):  
Gloria Donninelli ◽  
Manuela Del Cornò ◽  
Marina Pierdominici ◽  
Beatrice Scazzocchio ◽  
Rosaria Varì ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
T Cell ◽  
Visceral Adipose Tissue ◽  
Regulatory T Cell ◽  
Visceral Adipose

scholarly journals CD8+ T Cells Involved in Metabolic Inflammation in Visceral Adipose Tissue and Liver of Transgenic Pigs

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaiyi Zhang ◽  
Cong Tao ◽  
Jianping Xu ◽  
Jinxue Ruan ◽  
Jihan Xia ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
Visceral Adipose Tissue ◽  
Antigen Processing ◽  
Metabolic Diseases ◽  
Early Stage ◽  
Large Animal ◽  
Transgenic Pigs ◽  
Inflammatory Signaling ◽  
Visceral Adipose

Anti-inflammatory therapies have the potential to become an effective treatment for obesity-related diseases. However, the huge gap of immune system between human and rodent leads to limitations of drug discovery. This work aims at constructing a transgenic pig model with higher risk of metabolic diseases and outlining the immune responses at the early stage of metaflammation by transcriptomic strategy. We used CRISPR/Cas9 techniques to targeted knock-in three humanized disease risk genes, GIPRdn, hIAPP and PNPLA3I148M. Transgenic effect increased the risk of metabolic disorders. Triple-transgenic pigs with short-term diet intervention showed early symptoms of type 2 diabetes, including glucose intolerance, pancreatic lipid infiltration, islet hypertrophy, hepatic lobular inflammation and adipose tissue inflammation. Molecular pathways related to CD8+ T cell function were significantly activated in the liver and visceral adipose samples from triple-transgenic pigs, including antigen processing and presentation, T-cell receptor signaling, co-stimulation, cytotoxicity, and cytokine and chemokine secretion. The similar pro-inflammatory signaling in liver and visceral adipose tissue indicated that there might be a potential immune crosstalk between the two tissues. Moreover, genes that functionally related to liver antioxidant activity, mitochondrial function and extracellular matrix showed distinct expression between the two groups, indicating metabolic stress in transgenic pigs’ liver samples. We confirmed that triple-transgenic pigs had high coincidence with human metabolic diseases, especially in the scope of inflammatory signaling at early stage metaflammation. Taken together, this study provides a valuable large animal model for the clinical study of metaflammation and metabolic diseases.

Dietary habits affect fatty acid composition of visceral adipose tissue in subjects with colorectal cancer or obesity

2019 ◽  
Vol 59 (4) ◽  
pp. 1463-1472 ◽  
Author(s):  
B. Scazzocchio ◽  
R. Varì ◽  
A. Silenzi ◽  
S. Giammarioli ◽  
A. Masotti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Visceral Adipose Tissue ◽  
Dietary Habits ◽  
Visceral Adipose

scholarly journals Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel Castellano-Castillo ◽  
Sonsoles Morcillo ◽  
Ana B. Crujeiras ◽  
Lidia Sánchez-Alcoholado ◽  
Mercedes Clemente-Postigo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Global Dna Methylation ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Colorectal Cancer Patients ◽  
Visceral Adipose

623 Visceral Adipose Tissue Changes After Surgery in Colorectal Cancer Patients May Have Prognostic Implications

2014 ◽  
Vol 146 (5) ◽  
pp. S-1023-S-1024
Author(s):  
Eun Kyung Choe ◽  
Heung-Kwon Oh ◽  
Sang Hui Moon ◽  
Seung-Bum Ryoo ◽  
Kyu Joo Park
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Tissue Changes ◽  
Prognostic Implications ◽  
Colorectal Cancer Patients ◽  
Visceral Adipose

scholarly journals Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Hoon Lee ◽  
Soyoung Kim ◽  
Hye Sun Lee ◽  
Eun Jung Park ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Glucose Uptake ◽  
Visceral Adipose Tissue ◽  
Visceral Fat ◽  
Male And Female ◽  
Female Patients ◽  
Pet Ct ◽  
Visceral Adipose ◽  
Fat Volume

AbstractThe purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.

scholarly journals The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252547
Author(s):  
Xiaoxiang Yan ◽  
Natsumi Imano ◽  
Kayoko Tamaki ◽  
Motoaki Sano ◽  
Ken Shinmura
Keyword(s):  
Insulin Resistance ◽  
T Cells ◽  
Adipose Tissue ◽  
T Cell ◽  
Caloric Restriction ◽  
Visceral Adipose Tissue ◽  
Aged Mice ◽  
Age Related ◽  
Visceral Adipose

Aging is associated with functional decline in the immune system and increases the risk of chronic diseases owing to smoldering inflammation. In the present study, we demonstrated an age-related increase in the accumulation of Programmed Death-1 (PD-1)+ memory-phenotype T cells that are considered “senescence-associated T cells” in both the visceral adipose tissue and spleen. As caloric restriction is an established intervention scientifically proven to exert anti-aging effects and greatly affects physiological and pathophysiological alterations with advanced age, we evaluated the effect of caloric restriction on the increase in this T-cell subpopulation and glucose tolerance in aged mice. Long-term caloric restriction significantly decreased the number of PD-1+ memory-phenotype cluster of differentiation (CD) 4+ and CD8+ T cells in the spleen and visceral adipose tissue, decreased M1-type macrophage accumulation in visceral adipose tissue, and improved insulin resistance in aged mice. Furthermore, the immunological depletion of PD-1+ T cells reduced adipose inflammation and improved insulin resistance in aged mice. Taken together with our previous report, these results indicate that senescence-related T-cell subpopulations are involved in the development of chronic inflammation and insulin resistance in the context of chronological aging and obesity. Thus, long-term caloric restriction and specific deletion of senescence-related T cells are promising interventions to regulate age-related chronic diseases.

scholarly journals ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue

2021 ◽  
Vol 218 (6) ◽  
Author(s):  
Kristen L. Mittelsteadt ◽  
Erika T. Hayes ◽  
Daniel J. Campbell
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
Insulin Sensitivity ◽  
Visceral Adipose Tissue ◽  
Cell Accumulation ◽  
Elevated Expression ◽  
Phosphoinositide 3 Kinase ◽  
And Function ◽  
Adipose Inflammation ◽  
Visceral Adipose

A unique population of Foxp3+ regulatory T cells (TRs) resides in visceral adipose tissue (VAT) that regulates adipose inflammation and helps preserve insulin sensitivity. Inducible T cell co-stimulator (ICOS) is highly expressed on effector (e)TRs that migrate to nonlymphoid tissues, and contributes to their maintenance and function in models of autoimmunity. In this study, we report an unexpected cell-intrinsic role for ICOS expression and downstream phosphoinositide 3-kinase (PI3K) signaling in limiting the abundance, VAT-associated phenotype, and function of TRs specifically in VAT. Icos−/− mice and mice expressing a knock-in form of ICOS that cannot activate PI3K had increased VAT-TR abundance and elevated expression of canonical VAT-TR markers. Loss of ICOS signaling facilitated enhanced accumulation of TRs to VAT associated with elevated CCR3 expression, and resulted in reduced adipose inflammation and heightened insulin sensitivity in the context of a high-fat diet. Thus, we have uncovered a new and surprising molecular pathway that regulates VAT-TR accumulation and function.

25-Hydroxyvitamin D status is associated with interleukin-6 methylation in adipose tissue from patients with colorectal cancer

2021 ◽  
Author(s):  
Hatim Boughanem ◽  
Patricia Ruiz-Limon ◽  
Ana B. Crujeiras ◽  
Vanessa de Luque ◽  
Francisco J. Tinahones ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Proinflammatory Cytokines ◽  
Interleukin 6 ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Visceral Adipose

A dysfunctional visceral adipose tissue (VAT) is characterized by increased production of proinflammatory cytokines, which may increase the risk of colorectal cancer (CRC).

scholarly journals Obesity accelerates T cell senescence in murine visceral adipose tissue

2016 ◽  
Vol 126 (12) ◽  
pp. 4626-4639 ◽  
Author(s):  
Kohsuke Shirakawa ◽  
Xiaoxiang Yan ◽  
Ken Shinmura ◽  
Jin Endo ◽  
Masaharu Kataoka ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
Visceral Adipose Tissue ◽  
Cell Senescence ◽  
Visceral Adipose ◽  
T Cell Senescence

scholarly journals The Association of Abdominal Adiposity With Mortality in Patients With Stage I–III Colorectal Cancer

2019 ◽  
Vol 112 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Justin C Brown ◽  
Bette J Caan ◽  
Carla M Prado ◽  
Elizabeth M Cespedes Feliciano ◽  
Jingjie Xiao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Colorectal Cancer Patients ◽  
Subcutaneous Adiposity ◽  
Visceral Adipose ◽  
Subcutaneous Adipose ◽  
Shaped Pattern

Abstract Background The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients, and such associations may vary by patient sex. Methods This cohort included 3262 stage I–III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values. Results Visceral adipose tissue was prognostic of mortality in a reverse L-shaped pattern (nonlinear P = .02); risk was flat to a threshold (∼260 cm2) then increased linearly. Subcutaneous adipose tissue was prognostic of mortality in a J-shaped pattern (nonlinear P &lt; .001); risk was higher at extreme (&lt;50 cm2) but lower at intermediate values (&gt;50 to ≤560 cm2). Patient sex modified the prognostic associations between visceral adipose tissue (Pinteraction = .049) and subcutaneous adipose tissue (Pinteraction = .04) with mortality. Among men, visceral adiposity was associated with mortality in a J-shaped pattern (nonlinear P = .003), whereas among women, visceral adiposity was associated with mortality in a linear pattern (linear P = .008). Among men, subcutaneous adiposity was associated with mortality in an L-shaped pattern (nonlinear P = .01), whereas among women, subcutaneous adiposity was associated with mortality in a J-shaped pattern (nonlinear P &lt; .001). Conclusions Visceral and subcutaneous adipose tissue were prognostic of mortality in patients with colorectal cancer; the shape of these associations were often nonlinear and varied by patient sex. These results offer insight into the potential biological mechanisms that link obesity with clinical outcomes in patients with cancer, suggesting that the dysregulated deposition of excess adiposity is prognostic of mortality.

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