Gut microbiota modulation and anti-inflammatory properties of mixed lactobacilli in dextran sodium sulfate-induced colitis in mice

2021 ◽  
Author(s):  
Jialu Shi ◽  
Qing gang Xie ◽  
Yingxue Yue ◽  
Qingxue Chen ◽  
Lina Zhao ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Gut Microbiota ◽  
Lactobacillus Plantarum ◽  
Lactobacillus Acidophilus ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Lactobacillus Helveticus ◽  
Immunomodulatory Activity ◽  
Anti Inflammatory

Lactobacillus acidophilus KDSL 1.0901，Lactobacillus helveticus KDSL 1.8701and Lactobacillus plantarum KDSL 1.0318 showed antibacterial activity, antioxidant activity and immunomodulatory activity. In the current study, we evaluated the effects of three tested...

Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice

2020 ◽  
Vol 11 (12) ◽  
pp. 10736-10747
Author(s):  
Jialu Shi ◽  
Peng Du ◽  
Qinggang Xie ◽  
Nana Wang ◽  
Huizhen Li ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Gut Microbiota ◽  
Lactobacillus Plantarum ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Protective Effects ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Indole 3 Acetic Acid

L. plantarum KLDS 1.0386 combined with tryptophan alleviates ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) by increasing the level of indole-3-acetic acid (IAA), stimulating the AHR/IL-22/STAT3 signaling pathway and regulating gut microbiota in mice.

Inhibitory effects of β-type glycosidic polysaccharide from Pleurotus eryngii on dextran sodium sulfate-induced colitis in mice

2021 ◽  
Author(s):  
Gaoxing Ma ◽  
Qiuhui Hu ◽  
Yanhui Han ◽  
Hengjun Du ◽  
Wenjian Yang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Pleurotus Eryngii ◽  
Dextran Sodium Sulfate ◽  
Inhibitory Effects ◽  
Anti Inflammatory ◽  
Regulatory Effects ◽  
Natural Component

The present study demonstrated the anti-inflammatory and gut microbiota regulatory effects of a Pleurotus eryngii polysaccharide as a functional natural component and a beneficial prebiotic candidate against IBD.

scholarly journals Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses

mBio ◽  
2021 ◽  
Author(s):  
Qiufen Mo ◽  
Tao Liu ◽  
Aikun Fu ◽  
Shengyue Ruan ◽  
Hao Zhong ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Inflammatory Responses ◽  
Dextran Sodium Sulfate ◽  
Food Grade ◽  
Glycerol Monolaurate ◽  
Dietary Components ◽  
Anti Inflammatory

The gut microbiota, which can be highly and dynamically affected by dietary components, is closely related to IBD pathogenesis. Here, we demonstrated that food-grade glycerol monolaurate (GML)-mediated enhancement of Bifidobacterium and fecal SCFAs could be responsible for the anticolitis effect.

scholarly journals THE EFFECT OF MAHKOTA DEWA (PHALERIA MACROCARPA) (SCHEFF.) FRUIT PERICARP EXTRACT ON INOS IN MICE COLON INTERMITTENTLY-INDUCED BY DEXTRAN SODIUM SULFATE

2017 ◽  
Vol 10 (12) ◽  
pp. 309
Author(s):  
Kusmardi Kusmardi ◽  
Dilla Shavera ◽  
Ari Estuningtyas ◽  
Aryo Tedjo ◽  
Bambang Priyosoeryanto
Keyword(s):  
Sodium Sulfate ◽  
Total Yield ◽  
Ethanolic Extract ◽  
Dextran Sodium Sulfate ◽  
Inflammatory Activity ◽  
Fruit Pericarp ◽  
Phaleria Macrocarpa ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Different Doses

  Objective: The objective of this research was to investigate the anti-inflammatory effect of Mahkota Dewa fruit pericarp extract (Phaleria macrocarpa) on inducible nitric oxide synthase (iNOS) in mice colon induced by dextran sodium sulfate (DSS).Method: The simplisia of P. macrocarpa pericarp was weighed (1000 g) and extracted by maceration process. The total yield of the ethanolic extract was 26.43%. Phytochemical screening was carried out for the detection of the phytoconstituents by simple qualitative methods. The anti-inflammatory activity was performed by DSS-induced colitis model through assessment of hematoxylin-eosin staining and expression of iNOS by immunohistochemistry assay at four different doses, i.e., 650, 1250, 2500, and 5000 mg/kg. Swiss Webster male mice weighing 25-30 g were used for the study.Results: Inflammation score in dose 625, 1250, 2500, and 5000 mg/kg were 1.63, 1.43, 1.32, and 2.20, respectively. This result is significantly different (p=0.008) with DSS group that was 4.37. The results of iNOS optical density score in dose 625, 1250, 2500, and 5000 mg/kg were 1.21, 1.119, 1.22, and 1.37, respectively. This result was significantly different (p=0.000) with DSS group that was 2.24.Conclusion: Pericarp extract of P. macrocarpa fruit exhibited anti-inflammatory activity in the experimental model shown by suppressing the expression of inflammatory cell and iNOS. 

scholarly journals Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis

2018 ◽  
Vol 51 (1) ◽  
pp. 441-451 ◽  
Author(s):  
Gang Liu ◽  
Wenxin Yan ◽  
Sujuan  Ding ◽  
Hongmei Jiang ◽  
Yong Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Daily Weight Gain ◽  
Control Group ◽  
Unrestricted Access ◽  
Hematoxylin And Eosin ◽  
Colitis Model

Background/Aims: There are known links between inflammatory bowel disease (IBD) and changes in the microbiota of the gut and inflammation and oxidative stress. In this study, a colitis model induced by dextran sodium sulfate (DSS) in mice is used to evaluate whether the presence of bioactive peptides IRW (Ile-Arg-Trp) and IQW (Ile-Gln-Trp) peptides is advantageous. Methods: The mice were arbitrarily assigned to the following four groups: (i) control (untreated), (ii) dextran sodium sulfate (DSS) treated, (iii) IRW-DSS treated, and (iv) IQW-DSS treated. For 7 days, the control group subjects had unrestricted access to untreated drinking water, whereas the drinking water supplied to the subjects in the DSS, IRW-DSS, and IQW-DSS groups during this period consisted of 5% DSS solution. The colonic lesions were scored after hematoxylin and eosin staining. Serum antioxidant capacity was analyzed by 2,2’-azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) radical cation decolorization test and the microbiota in the colonic contents were sequenced by HiSeq2500 PE250. Results: The presence of DSS reduced daily weight gain, enhanced histopathology scores, and inhibited antioxidant enzyme expression. Superoxide dismutase, catalase, and glutathione peroxidase activities in the DSS-induced colitis model were significantly enhanced (P < 0.05) in the presence of dietary IRW and IQW. Furthermore, the Simpson index was significantly increased (P < 0.05) in the presence of dietary IRW and IQW compared to the control group. IRW and IQW increased the abundance of Coprococcus_1, Ruminococcaceae_UCG-014, and Desulfovibrio compared to the control group and DSS group. Furthermore, IQW decreased the abundance of Bacteroides in relation to the control group, but increased Parabacteroides. In addition, IRW increased the level of Anaerotruncus, Oscillibacter, and Ruminiclostridium_9 compared to the control group. Conclusion: This study concludes that the presence of IRW or IQW can mitigate DSS-induced oxidative stress by improving the activities of antioxidant enzymes, increasing intestinal microbial diversity and enhancing the abundance of gut microbiota, which may help maintain the homeostasis of host health and microenvironment in a DSS-induced mouse model, thus providing a potential further treatment for IBD patients.

scholarly journals Exopolysaccharides from Bacillus amyloliquefaciens DMBA-K4 ameliorate dextran sodium sulfate-induced colitis via gut microbiota modulation

2020 ◽  
Vol 75 ◽  
pp. 104212
Author(s):  
Jia-hua Kuang ◽  
Yan-yan Huang ◽  
Jin-shuang Hu ◽  
Jia-jia Yu ◽  
Qin-yu Zhou ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Bacillus Amyloliquefaciens ◽  
Dextran Sodium Sulfate

c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 Ameliorate Dextran Sodium Sulfate-Induced Colitis in Mice

2020 ◽  
Vol 68 (12) ◽  
pp. 3758-3769 ◽  
Author(s):  
Qing Ren ◽  
Bo Yang ◽  
Hao Zhang ◽  
R. Paul Ross ◽  
Catherine Stanton ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate
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