2-O-β-d-Glucopyranosyl-l-ascorbic Acid, an Ascorbic Acid Derivative Isolated from the Fruits of Lycium Barbarum L., Modulates Gut Microbiota and Palliates Colitis in Dextran Sodium Sulfate-Induced Colitis in Mice

2019 ◽  
Vol 67 (41) ◽  
pp. 11408-11419 ◽  
Author(s):  
Kaiyin Huang ◽  
Wei Dong ◽  
Wanyu Liu ◽  
Yamei Yan ◽  
Peng Wan ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Gut Microbiota ◽  
Acid Derivative ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Lycium Barbarum

scholarly journals Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis

2018 ◽  
Vol 51 (1) ◽  
pp. 441-451 ◽  
Author(s):  
Gang Liu ◽  
Wenxin Yan ◽  
Sujuan  Ding ◽  
Hongmei Jiang ◽  
Yong Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Daily Weight Gain ◽  
Control Group ◽  
Unrestricted Access ◽  
Hematoxylin And Eosin ◽  
Colitis Model

Background/Aims: There are known links between inflammatory bowel disease (IBD) and changes in the microbiota of the gut and inflammation and oxidative stress. In this study, a colitis model induced by dextran sodium sulfate (DSS) in mice is used to evaluate whether the presence of bioactive peptides IRW (Ile-Arg-Trp) and IQW (Ile-Gln-Trp) peptides is advantageous. Methods: The mice were arbitrarily assigned to the following four groups: (i) control (untreated), (ii) dextran sodium sulfate (DSS) treated, (iii) IRW-DSS treated, and (iv) IQW-DSS treated. For 7 days, the control group subjects had unrestricted access to untreated drinking water, whereas the drinking water supplied to the subjects in the DSS, IRW-DSS, and IQW-DSS groups during this period consisted of 5% DSS solution. The colonic lesions were scored after hematoxylin and eosin staining. Serum antioxidant capacity was analyzed by 2,2’-azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid) (ABTS) radical cation decolorization test and the microbiota in the colonic contents were sequenced by HiSeq2500 PE250. Results: The presence of DSS reduced daily weight gain, enhanced histopathology scores, and inhibited antioxidant enzyme expression. Superoxide dismutase, catalase, and glutathione peroxidase activities in the DSS-induced colitis model were significantly enhanced (P < 0.05) in the presence of dietary IRW and IQW. Furthermore, the Simpson index was significantly increased (P < 0.05) in the presence of dietary IRW and IQW compared to the control group. IRW and IQW increased the abundance of Coprococcus_1, Ruminococcaceae_UCG-014, and Desulfovibrio compared to the control group and DSS group. Furthermore, IQW decreased the abundance of Bacteroides in relation to the control group, but increased Parabacteroides. In addition, IRW increased the level of Anaerotruncus, Oscillibacter, and Ruminiclostridium_9 compared to the control group. Conclusion: This study concludes that the presence of IRW or IQW can mitigate DSS-induced oxidative stress by improving the activities of antioxidant enzymes, increasing intestinal microbial diversity and enhancing the abundance of gut microbiota, which may help maintain the homeostasis of host health and microenvironment in a DSS-induced mouse model, thus providing a potential further treatment for IBD patients.

scholarly journals Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Wanping Aw ◽  
Huijuan Jia ◽  
Weida Lyu ◽  
Shinji Fukuda ◽  
Masaru Tomita ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Lycium Barbarum ◽  
Integrated Omics

scholarly journals Exopolysaccharides from Bacillus amyloliquefaciens DMBA-K4 ameliorate dextran sodium sulfate-induced colitis via gut microbiota modulation

2020 ◽  
Vol 75 ◽  
pp. 104212
Author(s):  
Jia-hua Kuang ◽  
Yan-yan Huang ◽  
Jin-shuang Hu ◽  
Jia-jia Yu ◽  
Qin-yu Zhou ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Bacillus Amyloliquefaciens ◽  
Dextran Sodium Sulfate

Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice

2020 ◽  
Vol 11 (5) ◽  
pp. 4259-4274
Author(s):  
Ruiqiu Zhao ◽  
Yang Ji ◽  
Xin Chen ◽  
Anxiang Su ◽  
Gaoxing Ma ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Flammulina Velutipes ◽  
Anti Inflammation

Using the Flammulina velutipes polysaccharide (FVP) extracted from our previous study, herein, we investigated the improvement of this β-type glycosidic polysaccharide in alleviating dextran sodium sulfate-induced ulcerative colitis (UC) in mice.

scholarly journals Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

2020 ◽  
Vol 10 ◽  
Author(s):  
Hao Wu ◽  
Quan Rao ◽  
Guang-Chao Ma ◽  
Xiao-Hong Yu ◽  
Cong-En Zhang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice

2020 ◽  
Vol 11 (12) ◽  
pp. 10736-10747
Author(s):  
Jialu Shi ◽  
Peng Du ◽  
Qinggang Xie ◽  
Nana Wang ◽  
Huizhen Li ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Acetic Acid ◽  
Gut Microbiota ◽  
Lactobacillus Plantarum ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Protective Effects ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Indole 3 Acetic Acid

L. plantarum KLDS 1.0386 combined with tryptophan alleviates ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) by increasing the level of indole-3-acetic acid (IAA), stimulating the AHR/IL-22/STAT3 signaling pathway and regulating gut microbiota in mice.

scholarly journals Ginseng Polysaccharides and its Effective Subfraction Protects Against Dextran Sodium Sulfate-Induced Colitis via Regulating NF-κB Signaling Pathway, Recovering Intestinal Barrier and Adjusting Gut Microbiota

2021 ◽  
Author(s):  
Shanshan Li ◽  
Yuli Qi ◽  
Duoduo Ren ◽  
Yue Zhang ◽  
Yinshi Sun
Keyword(s):  
Gut Microbiota ◽  
Signaling Pathway ◽  
Sodium Sulfate ◽  
Intervention Strategy ◽  
Intestinal Barrier ◽  
Dextran Sodium Sulfate ◽  
Signalling Pathway ◽  
Ginseng Polysaccharide ◽  
Acidic Fraction ◽  
Related Proteins

Abstract Background: Polysaccharides from Panax ginseng is a natural carbohydrates with multiple activities. Our previous work found that ginseng polysaccharide could recover the gut microbiota dysbiosis caused by antibiotic. However, it was little known about its functions on colitis. In this study, we aim to investigate the protective effects of ginseng polysaccharide (WGP), its neutral fraction (WGPN) and acidic fraction (WGPA) on dextran sodium sulfate (DSS) induced colitis and the potential mechanisms with pharmacological experiments.Methods: Animal model of DSS-induced colitis was constructed by male Wistar rats. Disease activity index (DAI) scores, weight increment, colon weights, and colon length were recorded. Physiological and histological parameters, tight junctions proteins, inflammatory factors, gut microbiota, short-chain fatty acids (SCFAs) and NF-kB signalling pathway related proteins were compared among the five experimental groups, which were treated with a normal diet (Con group), DSS (DSS group), WGP (WGP group), WGPN (WGPN group), and WGPA (WGPA group), respectively. Results: Both WGP and WGPA alleviated the colitis symptoms and colon structure changes of colitis rats. They can decreased the DAIs and improved colon health; reduced colon damage and recovered intestinal barrier via regulating the tight-junction related proteins (ZO-1 and Occludin); downregulated inflammatory cytokines (IL-1β, IL-2, IL-6, and IL-17) and inhibited the TLR4/MyD88/NF-kB signalling pathway in the colon; regulated the diversity and composition of gut microbiota, especially the relative abundance of Ruminococcus; enhanced the production of SCFAs. Conclusions: WGP exerted had a protective effect against colitis through regulating NF-kB signaling pathway, recovering intestinal barrier and adjusting gut microbiota, with its acidic fraction (WGPA) primarily contributing to this activity. The results support to the utilization and investigation of ginseng polysaccharides as potential intervention strategy for the prevention of colitis.

Dihydroquercetin supplement alleviates colonic inflammation potentially through improved gut microbiota community in mice

2021 ◽  
Author(s):  
fan wan ◽  
Hui Han ◽  
Ruqing Zhong ◽  
Mengyu Wang ◽  
Shanlong Tang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

The purpose of the current study was to investigate the effect of dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ supplementation (3...

Effect of salicin on gut inflammation and on selected groups of gut microbiota in dextran sodium sulfate induced mouse model of colitis

2013 ◽  
Vol 63 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Nirmal Verma ◽  
Ravi Verma ◽  
Reena Kumari ◽  
Raju Ranjha ◽  
Jaishree Paul
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Gut Inflammation
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