Synthesis of pH-responsive cyclometalated iridium(III) complex and its application in selective killing of cancerous cells

2021 ◽  
Author(s):  
Peng Yang ◽  
Shaoqing Zhang ◽  
Ke Wang ◽  
Honglan Qi
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Normal Cells ◽  
Cancerous Cells

Cyclometalated iridium(III) complexes are promising candidates as photosensitizers (PSs) in photodynamic therapy (PDT). The challenge in PDT is selective killing of cancerous cells against its neighboring normal cells. In this...

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 826-838 ◽  
Author(s):  
Takahiro Nomoto ◽  
Shigeto Fukushima ◽  
Michiaki Kumagai ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Calcium Phosphate ◽  
Ph Responsive ◽  
Inorganic Hybrid ◽  
Normal Tissues

Organic–inorganic hybrid nanocarriers permit efficient photodynamic therapy with reduced damage to normal tissues.

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

2020 ◽  
Vol 56 (87) ◽  
pp. 13347-13350
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Gang Chen ◽  
Junxia Peng ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

Dopamine-based nanoparticles are constructed via Schiff base bonds to serve as pH-responsive drug nanocarriers for combined photodynamic therapy and chemotherapy.

scholarly journals Is the effect of Decitabine limited to hypomethylation and DNMTs?

2019 ◽  
Author(s):  
Sina Dalvand ◽  
Amin Namdari ◽  
Ashraf Alemi ◽  
Mohammad Hassan Meshkibaf ◽  
Sam Setayesh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Histone Deacetylases ◽  
Dna Methyltransferase ◽  
Chromatin Condensation ◽  
Dna Demethylation ◽  
Histone Tails ◽  
Normal Cells ◽  
Before And After ◽  
Cancerous Cells

Abstract Background: Histone modifications play a crucial role in chromatin structure. Among enzymes, which regulate these processes, histone deacetylases (HDACs) can remove acetyl groups from histone tails, thus increasing their interaction with DNA and leading to chromatin condensation. 5-Aza-2′-deoxycytidine (AZad) or Decitabine is a potent hypomethylating agent that incorporates into DNA and traps DNA methyltransferase in the form of a covalent protein–DNA adduct. Azad, not only change the gene expression through demethylation of the gene's promoter, but it also can change gene expression independently from DNA demethylation. So, the present study was to distinguish whether AZad in addition to inhibitory effects on DNA methyltransferase, can change HDAC3 and HDAC7 mRNA expression in NALM-6, HL-60 cancer cell lines. Methods: HL-60, NALM-6 and normal cells were cultured, and the treatment dose of the AZad was obtained (1µM) by the MTT test. Finally, HDAC3 and HDAC7 mRNA expression were measured by Real Time PCR in HL-60 and NALM-6 cancerous cells before and after treatment. In addition, HDAC3 and HDAC7 mRNA expression in un-treated HL-60 and NALM-6 cancerous cells were compared to the normal cells. Results: Our result revealed that expression of HDAC3 and HDAC7, in HL-60 and NALM-6 cells increases as compared to normal cells. After treatment of HL-60 and NALM-6 cells with AZad, HDAC3 and HDAC7 mRNA expression were decreased significantly. Conclusions: Our data showed, the effects of AZad are not limited to direct hypomethylation of DNMTs but it can indirectly affect other epigenetic factors, such as HDACs activity, through converging pathways. Keywords: HDAC3 ; HDAC7 ; HL-60; NALM-6 ; Decitabine ; AZad

scholarly journals Vitamin C − protective role in oxidative stress conditions induced in human normal colon cells by label free Raman spectroscopy and imaging

2021 ◽  
Author(s):  
Karolina Beton ◽  
Beata Brozek-Pluska
Keyword(s):  
Oxidative Stress ◽  
Raman Spectroscopy ◽  
Vitamin C ◽  
Human Colon ◽  
Protective Role ◽  
Spectroscopic Methods ◽  
Label Free ◽  
Normal Cells ◽  
Colon Cells ◽  
Cancerous Cells

Colorectal cancer is the second most frequently diagnosed cancer worldwide. Conventional diagnostics methods of colorectal cancer, can detect it in advanced stage. Spectroscopic methods, including Raman spectroscopy and imaging, are becoming more and more popular in medical applications, and allow fast, precise and unambiguous differentiation of healthy and cancerous samples. the most important advantage of Raman spectroscopy is ability to identify biomarkers that help in differentiation of healthy and cancerous cells based on biochemistry of sample and spectra typical for: lipids, proteins, DNA. The aim of the study was to evaluate the biochemical and structural features of human colon cell lines based on Raman spectroscopy and imaging: normal cells CCD-18 Co, normal cells CCD-18 Co under oxidative stress conditions, normal cells CCD-18 Co at first treated by using tert-Butyl hydroperoxide and then supplemented by vitamin C in high concentration to show the protective role of vitamin C in micromolar concentrations against ROS by spectroscopic methods. Raman data obtained for normal cells injured by ROS were compared with spectra typical for cancerous cells. Statistically assisted analysis has shown that normal, ROS injured and cancerous human colon cells can be distinguished based on their unique vibrational properties. The research carried out proves that label-free Raman spectroscopy may play an important role in clinical diagnostics differentiation of normal and cancerous colon cells and may be a source of intraoperative information supporting histopathological analysis.

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

2011 ◽  
Vol 47 (37) ◽  
pp. 10311 ◽  
Author(s):  
Xianchun Zhu ◽  
Wentong Lu ◽  
Yazhou Zhang ◽  
Aisha Reed ◽  
Brandon Newton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive

A new copper complex enhanced apoptosis in human breast cancerous cells without considerable effects on normal cells

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100475
Author(s):  
Fatemeh Mohammadizadeh ◽  
Mehdi Mahmoodi ◽  
Azadeh Rezaei ◽  
Maryam Mohamadi ◽  
Mohammad Reza Hajizadeh ◽  
...  
Keyword(s):  
Copper Complex ◽  
Human Breast ◽  
Normal Cells ◽  
Cancerous Cells

Characterization of endogenous fluorescence in nonsmall lung cancerous cells: A comparison with nonmalignant lung normal cells

2020 ◽  
Vol 13 (5) ◽  
Author(s):  
Kamlesh Awasthi ◽  
Feng‐Lin Chang ◽  
Pei‐Ying Hsieh ◽  
Hsin‐Yun Hsu ◽  
Nobuhiro Ohta
Keyword(s):  
Normal Cells ◽  
Endogenous Fluorescence ◽  
Cancerous Cells
Sign in / Sign up

Export Citation Format

Share Document