scholarly journals pH-Responsive Pluronic F127–Lenvatinib-Encapsulated Halogenated Boron-Dipyrromethene Nanoparticles for Combined Photodynamic Therapy and Chemotherapy of Liver Cancer

ACS Omega ◽  
2021 ◽  
Author(s):  
Jingjing Zong ◽  
Hao Peng ◽  
Xin Qing ◽  
Zhe Fan ◽  
Wenjing Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Liver Cancer ◽  
Pluronic F127 ◽  
Ph Responsive ◽  
Boron Dipyrromethene

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 826-838 ◽  
Author(s):  
Takahiro Nomoto ◽  
Shigeto Fukushima ◽  
Michiaki Kumagai ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Calcium Phosphate ◽  
Ph Responsive ◽  
Inorganic Hybrid ◽  
Normal Tissues

Organic–inorganic hybrid nanocarriers permit efficient photodynamic therapy with reduced damage to normal tissues.

In vitro and in vivo photocytotoxicity of boron dipyrromethene difluoride for photodynamic therapy

2011 ◽  
Vol 8 (2) ◽  
pp. 191-192
Author(s):  
S.H. Lim ◽  
C. Thivierge ◽  
P. Nowak-Sliwinska ◽  
J. Han ◽  
H. van den Bergh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

2020 ◽  
Vol 56 (87) ◽  
pp. 13347-13350
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Gang Chen ◽  
Junxia Peng ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

Dopamine-based nanoparticles are constructed via Schiff base bonds to serve as pH-responsive drug nanocarriers for combined photodynamic therapy and chemotherapy.

scholarly journals A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 28 ◽  
Author(s):  
Priyanga Dharmaratne ◽  
Ligang Yu ◽  
Roy Chi-Hang Wong ◽  
Ben Chun-Lap Chan ◽  
Kit-Man Lau ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Irritation ◽  
Scientific Basis ◽  
Positive Control ◽  
Methicillin Resistant ◽  
Boron Dipyrromethene ◽  
Mrsa Strains

Background: We report herein the synthesis of a novel dicationic boron dipyrromethene derivative (compound 3) which is symmetrically substituted with two trimethylammonium styryl groups. Methods: The antibacterial photodynamic activity of compound 3 was determined against sixteen methicillin-resistant Staphylococcus aureus (MRSA) strains, including four ATCC type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, and ATCC BAA-44), two mutant strains [AAC(6’)-APH(2”) and RN4220/pUL5054], and ten non-duplicate clinical strains of hospital- and communityassociated MRSA. Upon light irradiation, the minimum bactericidal concentrations of compound 3 were in the range of 1.56-50 µM against all the sixteen MRSA strains. Interestingly, compound 3 was not only more active than an analogue in which the ammonium groups are not directly connected to the pconjugated system (compound 4), but also showed significantly higher (p < 0.05) antibacterial potency than the clinically approved photosensitizer methylene blue. The skin irritation of compound 3 during topical application was tested on human 3-D skin constructs and proven to be non-irritant in vivo at concentrations below 1.250 mM. In the murine MRSA infected wound study, the colony forming unit reduction of compound 3 + PDT group showed significantly (p < 0.05) higher value (>2.5 log10) compared to other test groups except for the positive control. Conclusion: In conclusion, the present study provides a scientific basis for future development of compound 3 as a potent photosensitizer for photodynamic therapy for MRSA wound infection.

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

2011 ◽  
Vol 47 (37) ◽  
pp. 10311 ◽  
Author(s):  
Xianchun Zhu ◽  
Wentong Lu ◽  
Yazhou Zhang ◽  
Aisha Reed ◽  
Brandon Newton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive

Orange Trunk Waste-Based Lignin Nanoparticles Encapsulating Curcumin as a Photodynamic Therapy Agent against Liver Cancer

2021 ◽  
Author(s):  
Deyvid de Souza Porto ◽  
Bianca Martins Estevão ◽  
Paula Maria Pincela Lins ◽  
Nathália Cristina Rissi ◽  
Valtencir Zucolotto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Liver Cancer

scholarly journals A Phthalocyanine‐Based Glutathione‐Activated Photosensitizer with a Ferrocenyl Boron Dipyrromethene Dark Quencher for Photodynamic Therapy

ChemPhotoChem ◽  
2019 ◽  
Vol 3 (10) ◽  
pp. 970-970
Author(s):  
Wen‐Jing Shi ◽  
Dennis K. P. Ng ◽  
Shirui Zhao ◽  
Pui‐Chi Lo
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene
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