Au–Fe3O4 nanoagent coated cell membrane for targeted delivery and enhanced chem/photo therapy

2021 ◽  
Vol 57 (81) ◽  
pp. 10504-10507
Author(s):  
Yingshu Guo ◽  
Xiuping Cao ◽  
Shusheng Zhang
Keyword(s):  
Cell Membrane ◽  
Targeted Delivery ◽  
Treatment Process ◽  
Coated Cell ◽  
Membrane Coating

We report the preparation of a Au–Fe3O4 nanoagent cell membrane coating, and the treatment process in cell.

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

2021 ◽  
Vol 9 (8) ◽  
pp. 2991-3004
Author(s):  
Qian Xie ◽  
Yang Liu ◽  
Ying Long ◽  
Zhou Wang ◽  
Sai Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methyl Ester ◽  
Cell Membrane ◽  
Hybrid Cell ◽  
Combinational Therapy ◽  
Membrane Coating

Hybrid-cell membrane coating nanocomplexes loading chikusetsusaponin IVa methyl ester for combinational therapy against breast cancer assisted with Ce6.

Orchestration of biomimetic membrane coating and nanotherapeutics in personalized anticancer therapy

2021 ◽  
Author(s):  
Xuerui Chen ◽  
Bingbing Liu ◽  
Rongliang Tong ◽  
Lin Zhan ◽  
Xuelian Yin ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Anticancer Therapy ◽  
Coated Nanoparticles ◽  
Anticancer Treatment ◽  
Biomimetic Membrane ◽  
Membrane Coating

Benefiting from the special inherency of natural cells, diverse cell membrane-coated nanoparticles can facilitate personalized anticancer treatment.

scholarly journals MEMBRANE-COATING GRANULES OF KERATINIZING EPITHELIA

1965 ◽  
Vol 24 (2) ◽  
pp. 297-307 ◽  
Author(s):  
A. Gedeon Matoltsy ◽  
Paul F. Parakkal
Keyword(s):  
Electron Microscopy ◽  
Plasma Membrane ◽  
Epithelial Cells ◽  
Cell Envelope ◽  
Cell Periphery ◽  
Cell Surfaces ◽  
Intercellular Spaces ◽  
Cytoplasmic Granules ◽  
Coated Cell ◽  
Membrane Coating

The purpose of this study has been to obtain information on the development of the envelop of horny cells that resists the action of keratinolytic agents. Toward this end the epidermis, oral mucosa, and tongue epithelium of various vertebrates, as well as the isolated envelopes of horny cells, were examined by electron microscopy. It was found that small cytoplasmic granules (1,000 to 5,000 A) that develop within differentiating epithelial cells move toward the cell periphery, and after fusion with the plasma membrane, empty their contents into the intercellular spaces. The content of the granules spreads over the cell surfaces, and subsequently a thickened and coated cell envelope is formed that resists the action of keratinolytic agent. The membrane-coating granule is regarded as a specific differentiation product of the keratinizing epithelium. It contains numerous inner membranes and is assumed to engage in synthetic activities such as, perhaps, the formation of polysaccharides.

scholarly journals Cell membrane-formed nanovesicles for disease-targeted delivery

2016 ◽  
Vol 224 ◽  
pp. 208-216 ◽  
Author(s):  
Jin Gao ◽  
Dafeng Chu ◽  
Zhenjia Wang
Keyword(s):  
Cell Membrane ◽  
Targeted Delivery

scholarly journals Cell Membrane Coating Nanotechnology

2018 ◽  
Vol 30 (23) ◽  
pp. 1706759 ◽  
Author(s):  
Ronnie H. Fang ◽  
Ashley V. Kroll ◽  
Weiwei Gao ◽  
Liangfang Zhang
Keyword(s):  
Cell Membrane ◽  
Membrane Coating

scholarly journals Sulfatide-Rich Liposome Uptake by a Human-Derived Neuroblastoma Cell Line

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1615
Author(s):  
Daniel Arroyo-Ariza ◽  
Elizabeth Suesca ◽  
Chad Leidy ◽  
John M. Gonzalez
Keyword(s):  
Cell Membrane ◽  
Cell Line ◽  
Targeted Delivery ◽  
Neuroblastoma Cell ◽  
Density Lipoprotein ◽  
Chemotherapeutic Agents ◽  
Neuroblastoma Cell Line ◽  
Endocytic Pathway ◽  
Astrocytoma Cell Line ◽  
Astrocytoma Cell

Liposomes are bilayer membrane vesicles that can serve as vehicles for drug delivery. They are a good alternative to free drug administration that provides cell-targeted delivery into tumors, limiting the systemic toxicity of chemotherapeutic agents. Previous results from our group showed that an astrocytoma cell line exhibits selective uptake of sulfatide-rich (SCB) liposomes, mediated by the low-density lipoprotein receptor (LDL-R). The goal of this study was to assess the uptake of liposomes in a neuroblastoma cell line. For this purpose, we used two types of liposomes, one representing a regular cell membrane (DOPC) and another rich in myelin components (SCB). An astrocytoma cell line was used as a control. Characterization of liposome uptake and distribution was conducted by flow cytometry and fluorescence microscopy. Similar levels of LDL-R expression were found in both cell lines. The uptake of SCB liposomes was higher than that of DOPC liposomes. No alterations in cell viability were found. SCB liposomes were located near the cell membrane and did not colocalize within the acidic cellular compartments. Two endocytic pathway inhibitors did not affect the liposome uptake. Neuroblastoma cells exhibited a similar uptake of SCB liposomes as astrocytoma cells; however, the pathway involved appeared to be different than the hypothesized pathway of LDL-R clathrin-mediated endocytosis.

Co-biomembrane coated Fe3O4/MnO2 multifunctional nanoparticles for targeted delivery and enhanced hemodynamic/photothermal/chemo therapy

2021 ◽  
Author(s):  
Yingshu Guo ◽  
Xiaofei Zheng ◽  
Tingting Gai ◽  
Zhiyong Wei ◽  
Shu-Sheng Zhang
Keyword(s):  
Breast Cancer ◽  
Escherichia Coli ◽  
Drug Delivery ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Targeted Delivery ◽  
Membrane System ◽  
Multifunctional Nanoparticles ◽  
Mcf 7

Here, the co-membrane system of MCF-7 breast cancer cell membrane (MM) and Escherichia coli membrane (EM)-coated Fe3O4/MnO2 multifunctional composite nanoparticles loaded with DOX (Fe3O4/MnO2/MM/EM/D) was used for targeting drug delivery...

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