Orchestration of biomimetic membrane coating and nanotherapeutics in personalized anticancer therapy

2021 ◽  
Author(s):  
Xuerui Chen ◽  
Bingbing Liu ◽  
Rongliang Tong ◽  
Lin Zhan ◽  
Xuelian Yin ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Anticancer Therapy ◽  
Coated Nanoparticles ◽  
Anticancer Treatment ◽  
Biomimetic Membrane ◽  
Membrane Coating

Benefiting from the special inherency of natural cells, diverse cell membrane-coated nanoparticles can facilitate personalized anticancer treatment.

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

scholarly journals Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lizhi Liu ◽  
Xuan Bai ◽  
Maria-Viola Martikainen ◽  
Anna Kårlund ◽  
Marjut Roponen ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Immune Escape ◽  
Target Cells ◽  
Coated Nanoparticles ◽  
Internalization Mechanism ◽  
Cancer Nanomedicine ◽  
Biomimetic Nanoparticles ◽  
Membrane Coating ◽  
Time Specific

AbstractCell membrane coated nanoparticles (NPs) have recently been recognized as attractive nanomedical tools because of their unique properties such as immune escape, long blood circulation time, specific molecular recognition and cell targeting. However, the integrity of the cell membrane coating on NPs, a key metrics related to the quality of these biomimetic-systems and their resulting biomedical function, has remained largely unexplored. Here, we report a fluorescence quenching assay to probe the integrity of cell membrane coating. In contradiction to the common assumption of perfect coating, we uncover that up to 90% of the biomimetic NPs are only partially coated. Using in vitro homologous targeting studies, we demonstrate that partially coated NPs could still be internalized by the target cells. By combining molecular simulations with experimental analysis, we further identify an endocytic entry mechanism for these NPs. We unravel that NPs with a high coating degree (≥50%) enter the cells individually, whereas the NPs with a low coating degree (<50%) need to aggregate together before internalization. This quantitative method and the fundamental understanding of how cell membrane coated NPs enter the cells will enhance the rational designing of biomimetic nanosystems and pave the way for more effective cancer nanomedicine.

Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

2021 ◽  
Vol 9 (8) ◽  
pp. 2991-3004
Author(s):  
Qian Xie ◽  
Yang Liu ◽  
Ying Long ◽  
Zhou Wang ◽  
Sai Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methyl Ester ◽  
Cell Membrane ◽  
Hybrid Cell ◽  
Combinational Therapy ◽  
Membrane Coating

Hybrid-cell membrane coating nanocomplexes loading chikusetsusaponin IVa methyl ester for combinational therapy against breast cancer assisted with Ce6.

Anticancer Therapy in COViD-19 Patients: A Descriptive Literature Review

2021 ◽  
Vol 36 (8) ◽  
pp. 365-373
Author(s):  
Nishita Tripathi ◽  
Daniya Sheikh ◽  
Demetra Antimisiaris
Keyword(s):  
Literature Review ◽  
Older People ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Anticancer Therapy ◽  
Included Study ◽  
Adverse Outcomes ◽  
Control And Prevention ◽  
Anticancer Treatment ◽  
American Society

OBJECTIVE: To provide a descriptive literature review about the effects of anticancer treatment on clinical outcomes because of active COVID-19 infection in older people. DATA SOURCES: A literature search was conducted in Google Scholar, PubMed, American Society of Clinical Oncology, European Society for Medical Oncology, and the Center for Disease Control and Prevention. Articles published in English between December 1, 2019, to September 1, 2020, were included. STUDY SELECTION: Nine studies assessing the effectiveness of various modalities for cancer treatments in patients infected with COVID-19 infection were reviewed. The studies reviewed the severity of COVID-19 infection outcomes in patients who underwent any anticancer treatment. Studies exclusively focused on older people could not be found, but all studies included older people. DATA SYNTHESiS AND RESULTS: Early pandemic studies suggested avoiding anticancer treatment during a COVID-19 infection because of poor clinical outcomes and increased mortality. However, the totality of studies reviewed found no association between the continuation of anticancer treatment and adverse COVID-19 outcomes in cancer patients. Adverse COVID-19 infection outcomes and high mortality rates were associated with older cancer patients independent of anticancer therapy. CONCLUSION: Treatment of cancer could be challenging because of the COVID-19 pandemic. Interruption or delaying the anticancer therapy could increase the burden of overall mortality. This literature review indicated that adverse outcomes because of COVID-19 are associated with advanced age independent of anticancer therapy. Further exploration of the correlation between cancer, anticancer treatments, and COVID-19 infection outcomes is needed.

Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy

2020 ◽  
Vol 112 ◽  
pp. 1-13 ◽  
Author(s):  
Hong-Ying Chen ◽  
Jiang Deng ◽  
Yu Wang ◽  
Cheng-Qiong Wu ◽  
Xian Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Diagnosis ◽  
Hybrid Cell ◽  
Diagnosis And Therapy ◽  
Coated Nanoparticles ◽  
Cancer Diagnosis And Therapy

Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy

Nano Letters ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 936-946 ◽  
Author(s):  
Di Nie ◽  
Zhuo Dai ◽  
Jialin Li ◽  
Yiwei Yang ◽  
Ziyue Xi ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Cancer Chemotherapy ◽  
Shell Structure ◽  
Coated Nanoparticles

Silver-Coated Nanoparticles Combined with Doxorubicin for Enhanced Anticancer Therapy

2018 ◽  
Vol 14 (2) ◽  
pp. 312-320 ◽  
Author(s):  
Lijun Yang ◽  
Yang Gao ◽  
Jinjian Liu ◽  
Yumin Zhang ◽  
Chunhua Ren ◽  
...  
Keyword(s):  
Anticancer Therapy ◽  
Coated Nanoparticles

Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery

2021 ◽  
Author(s):  
Mian Wang ◽  
Yuanfeng Xin ◽  
Hao Cao ◽  
Wanlu Li ◽  
Yifei Hua ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Membrane ◽  
Coated Nanoparticles ◽  
Recent Advances

Studies of nanomedicine have achieved dramatic progress in recent decades.

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