scholarly journals A site-selective and stereospecific cascade Suzuki–Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls

2021 ◽  
Vol 57 (32) ◽  
pp. 3909-3912
Author(s):  
Suzanne Willems ◽  
Georgios Toupalas ◽  
Julia C. Reisenbauer ◽  
Bill Morandi
Keyword(s):  
Cross Coupling ◽  
Site Selectivity ◽  
A Site ◽  
Site Selective

A cascade Suzuki–Miyaura cross-coupling between two non-symmetrical coupling partners gave rise to 9,10-dihydrophenanthrenes with full site-selectivity. The choice of base was critical to facilitate the challenging coupling of the secondary boronate group.

scholarly journals Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

2017 ◽  
Vol 8 (1) ◽  
pp. 40-62 ◽  
Author(s):  
Joshua Almond-Thynne ◽  
David C. Blakemore ◽  
David C. Pryde ◽  
Alan C. Spivey
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selectivity ◽  
Site Selective

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB and CAS Scifinder® databases, factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends.

New Zinc-bis(Dialkylamides) Potentially Usable as Site-Selective Dopants For p-Type ZnSe.

1993 ◽  
Vol 334 ◽  
Author(s):  
William S. Rees ◽  
Oliver Just
Keyword(s):  
Vapor Pressure ◽  
Gas Phase ◽  
Elemental Analysis ◽  
Vapor Pressures ◽  
Effective Utilization ◽  
Site Selectivity ◽  
A Site ◽  
P Type ◽  
Site Selective ◽  
C Nmr

AbstractIn earlier work, the effective utilization of Zn {N\Si(CH3)3]2}2 as a site-selective dopant for the production of p-type ZnSe by OMVPE was demonstrated. Several new zinc-bis(dialkylamides) of the general form (R)(R′)NZnN(R″)(R‴) now have been prepared. They have been characterized by 1H- and 13C-NMR, GC/MS and elemental analysis. Vapor pressures and gas phase decompositior profiles have been examined. Correlations of vapor pressure and structure are discussed for this series of compounds. A mechanism for the site-selectivity observed in the incorporation of nitrogen is proposed.

1,3-Dipolar cycloadditions with meso-tetraarylchlorins – site selectivity and mixed bisadducts

2017 ◽  
Vol 4 (4) ◽  
pp. 534-544 ◽  
Author(s):  
José Almeida ◽  
António Aguiar ◽  
Andreia Leite ◽  
André M. N. Silva ◽  
Luís Cunha-Silva ◽  
...  
Keyword(s):  
Azomethine Ylide ◽  
Dipolar Cycloadditions ◽  
Porphyrin Macrocycle ◽  
Selective Approach ◽  
Site Selectivity ◽  
Sequential Addition ◽  
A Site ◽  
Site Selective

Mixed bisadducts resulting from the sequential addition of a nitrone and an azomethine ylide to the porphyrin macrocycle were efficiently obtained, in a site selective approach.

Iridium-Catalyzed Site-Selective C–H Borylation of 2-Pyridones

Synthesis ◽  
2017 ◽  
Vol 49 (21) ◽  
pp. 4745-4752 ◽  
Author(s):  
Koji Hirano ◽  
Masahiro Miura ◽  
Wataru Miura
Keyword(s):  
Cross Coupling ◽  
Site Selectivity ◽  
Steric Factors ◽  
Judicious Choice ◽  
Site Selective

An iridium-catalyzed site-selective C–H borylation of 2-pyridones has been developed. The site selectivity is predominantly controlled by steric factors, and we can access C4, C5, and C6 C–H on the 2-pyridone ring by the judicious choice of ligand and solvent. Subsequent Suzuki–Miyaura cross-coupling of the borylated products also proceeds to form the corresponding arylated pyridones in good overall yields.

Synthesis of functionalized para- and meta-terphenyls based on site-selective Suzuki cross-coupling reactions of bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate

2013 ◽  
Vol 91 (11) ◽  
pp. 1048-1058 ◽  
Author(s):  
Muhammad Nawaz ◽  
Ihsan Ullah ◽  
Obaid-ur-Rahman Abid ◽  
Asad Ali ◽  
Tamás Patonay ◽  
...  
Keyword(s):  
Carbon Atom ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Cross Coupling Reaction ◽  
Site Selectivity ◽  
Good Site ◽  
Site Selective

The palladium(0)-catalyzed Suzuki cross-coupling reaction of the bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate afforded para- and meta-terphenyls, respectively. The reactions proceeded with very good site selectivity in favor of the sterically less hindered carbon atom.

scholarly journals Heterogeneous Suzuki–Miyaura coupling of heteroaryl ester via chemoselective C(acyl)–O bond activation

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17266-17272 ◽  
Author(s):  
Hongpeng Ma ◽  
Chaolumen Bai ◽  
Yong-Sheng Bao
Keyword(s):  
Bond Activation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Palladium Nanoparticle ◽  
Arylboronic Acids ◽  
Cross Coupling Reaction ◽  
Supported Palladium ◽  
A Site ◽  
Site Selective

A site-selective supported palladium nanoparticle catalyzed Suzuki–Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed.

scholarly journals Diverse nucleosome Site-Selectivity among histone deacetylase complexes

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Zhipeng A Wang ◽  
Christopher J Millard ◽  
Chia-Liang Lin ◽  
Jennifer E Gurnett ◽  
Mingxuan Wu ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Protein Complexes ◽  
Histone H3 ◽  
Biological Functions ◽  
Sharp Reduction ◽  
Cellular Functions ◽  
Site Specific ◽  
Site Selectivity ◽  
A Site ◽  
Site Selective

Histone acetylation regulates chromatin structure and gene expression and is removed by histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to confer distinct cellular functions, but how the multi-subunit complexes influence deacetylase activities and site-selectivities in chromatin is poorly understood. Previously we reported the results of studies on the HDAC1 containing CoREST complex and acetylated nucleosome substrates which revealed a notable preference for deacetylation of histone H3 acetyl-Lys9 vs. acetyl-Lys14 (Wu et al, 2018). Here we analyze the enzymatic properties of five class I HDAC complexes: CoREST, NuRD, Sin3B, MiDAC and SMRT with site-specific acetylated nucleosome substrates. Our results demonstrate that these HDAC complexes show a wide variety of deacetylase rates in a site-selective manner. A Gly13 in the histone H3 tail is responsible for a sharp reduction in deacetylase activity of the CoREST complex for H3K14ac. These studies provide a framework for connecting enzymatic and biological functions of specific HDAC complexes.

Chemical and Electrochemical Heteroepitaxial Growth of Chalcogenide Semiconductors from Solutions

1996 ◽  
Vol 451 ◽  
Author(s):  
D. Lincot ◽  
M. J. Furlong ◽  
M. Froment ◽  
R. Cortes ◽  
M. C. Bernard
Keyword(s):  
Heteroepitaxial Growth ◽  
X Ray Diffraction ◽  
Basic Principles ◽  
Lattice Match ◽  
X Ray ◽  
Chalcogenide Semiconductors ◽  
Influence Of Temperature On ◽  
Deposition Processes ◽  
A Site ◽  
Site Selective

ABSTRACTChalcogenide semiconductors have been deposited epitaxially from aqueous solutions either chemically or electrochemically at growth rates of up to 0.7 μmhr−1. After recalling the basic principles of these deposition processes, results are presented concerning chemically deposited CdS on InP, GaP and CuInSe2 substrates, electrodeposited CdTe on InP, and CdSAnP heterostructures. Characterisation of these structures by RHEED, TEM, HRTEM, and glazing angle X ray diffraction allows to analyse the effects of substrate orientation, polarity, lattice match plus the influence of temperature on epitaxial growth. These results are discussed in terms of self organisation and a site selective growth mechanisms due to the free enegy of formation of each compound.

Sign in / Sign up

Export Citation Format

Share Document