scholarly journals Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

2017 ◽  
Vol 8 (1) ◽  
pp. 40-62 ◽  
Author(s):  
Joshua Almond-Thynne ◽  
David C. Blakemore ◽  
David C. Pryde ◽  
Alan C. Spivey
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selectivity ◽  
Site Selective

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources and Pfizer's global chemistry RKB and CAS Scifinder® databases, factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends.

Synthesis of functionalized para- and meta-terphenyls based on site-selective Suzuki cross-coupling reactions of bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate

2013 ◽  
Vol 91 (11) ◽  
pp. 1048-1058 ◽  
Author(s):  
Muhammad Nawaz ◽  
Ihsan Ullah ◽  
Obaid-ur-Rahman Abid ◽  
Asad Ali ◽  
Tamás Patonay ◽  
...  
Keyword(s):  
Carbon Atom ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Cross Coupling Reaction ◽  
Site Selectivity ◽  
Good Site ◽  
Site Selective

The palladium(0)-catalyzed Suzuki cross-coupling reaction of the bis(triflates) of methyl 2,5-dihydroxybenzoate and methyl 2,4-dihydroxybenzoate afforded para- and meta-terphenyls, respectively. The reactions proceeded with very good site selectivity in favor of the sterically less hindered carbon atom.

scholarly journals Synthesis of Functionalized p-Terphenyls Based on Site-Selective Suzuki Cross-Coupling Reactions of Bis(triflates) of 2,5-Dihydroxybenzoate

Synlett ◽  
2009 ◽  
Vol 2010 (01) ◽  
pp. e1-e1
Author(s):  
Peter Langer ◽  
Muhammad Nawaz ◽  
Muhammad Ibad ◽  
Obaid-Ur-Rahman Abid ◽  
Rasheed Khera ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selective

Site Selective Synthesis of PentaarylpyridinesviaMultiple Suzuki-Miyaura Cross-Coupling Reactions

2014 ◽  
Vol 356 (9) ◽  
pp. 1987-2008 ◽  
Author(s):  
Sebastian Reimann ◽  
Peter Ehlers ◽  
Andranik Petrosyan ◽  
Stefanie Kohse ◽  
Anke Spannenberg ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Selective Synthesis ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selective

ChemInform Abstract: Site-Selective Suzuki-Miyaura Cross-Coupling Reactions of the Bis(triflate) of Methyl 3,7-Dihydroxy-2-naphthoate.

ChemInform ◽  
2014 ◽  
Vol 45 (8) ◽  
pp. no-no
Author(s):  
Zien Khaddour ◽  
Nadi Eleya ◽  
Omer A. Akrawi ◽  
Aws M. Hamdy ◽  
Tamas Patonay ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selective

ChemInform Abstract: Programmed Synthesis of Tetraarylthieno[3,2-b]thiophene by Site-Selective Suzuki Cross-Coupling Reactions of Tetrabromothieno[3,2-b]thiophene.

ChemInform ◽  
2014 ◽  
Vol 45 (24) ◽  
pp. no-no
Author(s):  
Hien Nguyen ◽  
Dung Xuan Nguyen ◽  
Thinh Quang Tran ◽  
Binh Ngoc Vo ◽  
Thao Huong Nguyen ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selective

Flexible Strategy for Differentially 3,5-Disubstituted 4-Oxypyridin-2(1H)-ones Based on Site-Selective Pd-Catalyzed Cross-Coupling Reactions†

2007 ◽  
Vol 9 (2) ◽  
pp. 271-274 ◽  
Author(s):  
David Conreaux ◽  
Emmanuel Bossharth ◽  
Nuno Monteiro ◽  
Philippe Desbordes ◽  
Jean-Pierre Vors ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selective

scholarly journals ChemInform Abstract: Controlling Site Selectivity in Pd-Catalyzed Oxidative Cross-Coupling Reactions.

ChemInform ◽  
2011 ◽  
Vol 42 (31) ◽  
pp. no-no
Author(s):  
Thomas W. Lyons ◽  
Kami L. Hull ◽  
Melanie S. Sanford
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Site Selectivity
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