Microwave hyperthermia-responsible flexible liposomal gel as a novel transdermal delivery of methotrexate for enhanced rheumatoid arthritis therapy

2021 ◽  
Author(s):  
Qiying Shen ◽  
Ting Tang ◽  
Quan Hu ◽  
Xiaoying Ying ◽  
Gaofeng Shu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
Temperature Sensitive ◽  
Microwave Hyperthermia

Schematic of MTX-loaded temperature-sensitive flexible liposomal gel combined with microwave for treatment of RA.

scholarly journals Dual-stimuli responsive liposomes using pH- and temperature-sensitive polymers for controlled transdermal delivery

2017 ◽  
Vol 8 (9) ◽  
pp. 1507-1518 ◽  
Author(s):  
Naoko Yamazaki ◽  
Takumi Sugimoto ◽  
Mitsuhiro Fukushima ◽  
Ryoma Teranishi ◽  
Aki Kotaka ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Transdermal Penetration

The use of skin environment-sensitive liposomes for transdermal penetration is beneficial for improving cosmetic efficacy.

Development of novel pH-sensitive nanoparticle-based transdermal patch for management of rheumatoid arthritis

Nanomedicine ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. 603-624 ◽  
Author(s):  
Dildar Khan ◽  
Maimoona Qindeel ◽  
Naveed Ahmed ◽  
Ashraf U Khan ◽  
Salman Khan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
Therapeutic Potential ◽  
Ph Sensitive ◽  
In Vivo Studies ◽  
Transdermal Patch ◽  
Inflammatory Models ◽  
Average Size ◽  
Central Composite

Aim: To formulate and evaluate a pH-responsive nanoparticle (NP)-based patch for efficient transdermal delivery of flurbiprofen against rheumatoid arthritis. Materials & methods: Nanoprecipitation technique was used for preparation of NPs and central composite design was employed for optimization purposes. Optimized NPs were loaded into the transdermal patch by the solvent evaporation method. Results: Prepared NPs exhibited an average size of 69 nm, while NPs loaded onto the transdermal patch showed sustained release and high permeation through the skin. In in vivo studies, the prepared carrier system elucidated high therapeutic potential in both acute and chronic inflammatory models as evident from the results of behavioral, radiological, histopathological and antioxidant analyses. Conclusion: The flurbiprofen-loaded pH-sensitive NP-based transdermal patch has the potential to manage rheumatoid arthritis effectively.

scholarly journals Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 1140-1154 ◽  
Author(s):  
Shahira F. El Menshawe ◽  
Mohamed M. Nafady ◽  
Heba M. Aboud ◽  
Rasha M. Kharshoum ◽  
Asmaa Mohammed M. Hussein Elkelawy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Transdermal Delivery ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

scholarly journals AB0079 Transdermal delivery of methotrexate in rheumatoid arthritis: are we deep enough?

2017 ◽  
Author(s):  
B Sadarani ◽  
A Majumdar ◽  
P Kamble ◽  
S Paradkar ◽  
A Mathur ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery

scholarly journals Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 235 ◽  
Author(s):  
Jian Cao ◽  
Nan Zhang ◽  
Ziyi Wang ◽  
Jingjing Su ◽  
Jing Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
In Vitro Bioactivity ◽  
In Vivo Evaluation ◽  
Adjuvant Induced Arthritis ◽  
Tnf Α ◽  
Good Biocompatibility ◽  
New Treatment

Rheumatoid arthritis (RA) is a complicated autoimmune disease. The clinical applications of etanercept (EN), a TNF-α inhibitor, can efficiently halt the development of RA. EN is mainly administrated by subcutaneous injection, which may cause low compliance, side effects, and infection risk. In this study, a hyaluronic acid crosslinked microneedle system (MN) was constructed as the transdermal alternative to deliver EN. We describe the formulation, fabrication, characterization, and transdermal insertion study of MN. In vitro bioactivity of EN was conducted and analyzed by dynamic light scattering and circular dichroism spectrum. In vivo evaluation of MN was studied on adjuvant-induced arthritis mice. The MN possessed sufficient mechanical strength, good biocompatibility, little influence on the bioactivity of EN, and high anti-inflammatory efficacy. This work represents a successful example of delivering macromolecule therapeutic treatment by MN for RA treatment. The transdermal delivery of EN by MN offers a new treatment option for RA patients.

Intra-articular injection of indomethacin–methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis

2020 ◽  
Vol 8 (5) ◽  
pp. 993-1007 ◽  
Author(s):  
Na Yin ◽  
Xueting Guo ◽  
Rong Sun ◽  
Hongbing Liu ◽  
Lihua Tang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Temperature Sensitive ◽  
In Situ Hydrogel ◽  
Temperature Sensitive Hydrogel

Intra-articular injection of a temperature-sensitive hydrogel containing D-NPs formed by PEI-SS and IND and MTX.

scholarly journals New Horizons in Hydrogels for Methotrexate Delivery

Gels ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. 2
Author(s):  
Ali Dehshahri ◽  
Anuj Kumar ◽  
Vijay Sagar Madamsetty ◽  
Ilona Uzieliene ◽  
Shima Tavakol ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Central Nervous System ◽  
Transdermal Delivery ◽  
State Of The Art ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
New Horizons ◽  
Poor Absorption ◽  
Plasma Half Life ◽  
Novel Delivery Systems

Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

scholarly journals Development of CelecoxibTransfersomal gel for the Treatment of Rheumatoid Arthritis

2014 ◽  
Vol 2 (02) ◽  
pp. 07-13 ◽  
Author(s):  
Preeti . ◽  
Murugesan Senthil Kumar
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
Ex Vivo ◽  
Skin Irritation ◽  
Entrapment Efficiency ◽  
Sodium Deoxycholate ◽  
Vesicle Shape ◽  
Gel Formulations

The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for various parameters including vesicle shape, size and size distribution, surface morphology, entrapment efficiency, in-vitro and ex-vivo drug release and in-vivo anti-inflammatory activity. Vesicles were also evaluated for skin irritation study and permeation studies.Results of all the studies suggested that CelecoxibTransfersomal gel formulation was therapeutically effective drug delivery system for treatment of Rheumatoid Arthritis.

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