scholarly journals Dual-stimuli responsive liposomes using pH- and temperature-sensitive polymers for controlled transdermal delivery

2017 ◽  
Vol 8 (9) ◽  
pp. 1507-1518 ◽  
Author(s):  
Naoko Yamazaki ◽  
Takumi Sugimoto ◽  
Mitsuhiro Fukushima ◽  
Ryoma Teranishi ◽  
Aki Kotaka ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Transdermal Penetration

The use of skin environment-sensitive liposomes for transdermal penetration is beneficial for improving cosmetic efficacy.

scholarly journals Layer-by-Layer 3D Constructs of Fibroblasts in Hydrogel for Examining Transdermal Penetration Capability of Nanoparticles

2016 ◽  
Vol 22 (4) ◽  
pp. 447-453 ◽  
Author(s):  
Xiaochun Hou ◽  
Shiying Liu ◽  
Min Wang ◽  
Christian Wiraja ◽  
Wei Huang ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Surface Charges ◽  
Skin Model ◽  
Collagen Hydrogel ◽  
Penetration Ability ◽  
Charged Nanoparticles ◽  
Transdermal Penetration ◽  
Positively Charged

Nanoparticles are emerging transdermal delivery systems. Their size and surface properties determine their efficacy and efficiency to penetrate through the skin layers. This work utilizes three-dimensional (3D) bioprinting technology to generate a simplified artificial skin model to rapidly screen nanoparticles for their transdermal penetration ability. Specifically, this model is built through layer-by-layer alternate printing of blank collagen hydrogel and fibroblasts. Through controlling valve on-time, the spacing between printing lines could be accurately tuned, which could enable modulation of cell infiltration in the future. To confirm the effectiveness of this platform, a 3D construct with one layer of fibroblasts sandwiched between two layers of collagen hydrogel is used to screen silica nanoparticles with different surface charges for their penetration ability, with positively charged nanoparticles demonstrating deeper penetration, consistent with the observation from an existing study involving living skin tissue.

scholarly journals Stimuli-Responsive Shape Switching of Polymer Colloids by Temperature-Sensitive Absorption of Solvent

2016 ◽  
Vol 128 (34) ◽  
pp. 10106-10109 ◽  
Author(s):  
Huaguang Wang ◽  
Binghui Li ◽  
Arjun G. Yodh ◽  
Zexin Zhang
Keyword(s):  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Polymer Colloids

scholarly journals Radiolytic synthesis of gold nanoparticles in HEMA-based hydrogels: Potentialities for imaging nanocomposites

Nukleonika ◽  
2021 ◽  
Vol 66 (4) ◽  
pp. 165-177
Author(s):  
Katsiaryna Dziarabina ◽  
Uliana Pinaeva ◽  
Sławomir Kadłubowski ◽  
Piotr Ulański ◽  
Xavier Coqueret
Keyword(s):  
Gold Nanoparticles ◽  
Monomer Conversion ◽  
Thermomechanical Properties ◽  
Temperature Sensitive ◽  
Trimethylammonium Chloride ◽  
Stimuli Responsive ◽  
Monomer Composition ◽  
Swelling Characteristics ◽  
High Degree ◽  
Radiolytic Synthesis

Abstract This article reports on the radiolytic synthesis of nanocomposites containing gold nanoparticles (AuNPs) within two types of hydrogels based on 2-hydroxyethyl methacrylate (HEMA): (i) plain networks with various contents in ethylene glycol dimethacrylate (EGDMA), as a cross-linker and (ii) stimuli-responsive (SR) networks prepared from these monomers copolymerized with [2-(methacryloyloxy)ethyl]trimethylammonium chloride (MADQUAT) to confer pH-switchable swelling. Hydrogels were prepared by photopolymerization with well-defined composition and a high degree of monomer conversion using two experimental procedures, as xerogels or in aqueous solution. Besides MADQUAT, acrylic acid (AA) or N-isopropylacrylamide have been tested as copolymers, yielding pHor temperature-sensitive hydrogels, respectively. Isothermal swelling in water was affected by monomer composition. Electron beam (EB) irradiation at doses up to 100 kGy of poly(HEMA) xerogels and water-swollen networks prepared with 0.5 wt% of EGDMA had a moderate impact on swelling characteristics and thermomechanical properties of the plain materials, whereas small amounts of extractables were formed. Poly(HEMA)-based nanocomposites containing AuNPs were successfully obtained by EB irradiation of samples swollen by aqueous solutions of Au(III). The effects of dose and cross-linking density on the formation of AuNPs were monitored by UV-visible spectroscopy. Irradiation at well-defined temperatures of the Au(III)-loaded SR hydrogels induced the formation of nanoparticles with size-dependent features, whereas the efficiency of Au(III) reduction at 10 kGy was not significantly affected by the network structure. EB-induced reduction of Au(III) in poly(HEMA) hydrogels using a lead mask to generate well-defined patterns yielded coloured and long-lasting images in the zones where the nanocomposite was formed.

Dual CO2/temperature-responsive diblock copolymers confer controlled reversible emulsion behavior

2019 ◽  
Vol 10 (21) ◽  
pp. 2641-2646 ◽  
Author(s):  
Yeong-Tarng Shieh ◽  
Pei-Yu Tai ◽  
Chih-Chia Cheng
Keyword(s):  
Diblock Copolymers ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Temperature Responsive

Dual-stimuli responsive diblock copolymers possessing unique temperature-sensitive and CO2/N2-switching ability were successfully developed to promote efficient manipulation of reversible emulsification processes.

scholarly journals Study on the Effect of 1-Butanol Soluble Lignin on Temperature-Sensitive Gel

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1109 ◽  
Author(s):  
Pan Jiang ◽  
Yi Cheng ◽  
Sheng Yu ◽  
Jie Lu ◽  
Haisong Wang
Keyword(s):  
Environmental Temperature ◽  
Hydroxyl Group ◽  
Solution Temperature ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Agricultural Field ◽  
Absorption Properties ◽  
Critical Solution Temperature ◽  
Temperature Sensitive Hydrogel ◽  
Soluble Lignin

A protocol for the fractionation of lignin with 1-butanol as solvent has been proposed in order to improve the utilization of industry alkali lignin. 1-butanol soluble lignin (BSL) was used as a building block for temperature-sensitive hydrogel with N-isopropylacrylamide (NIPAAm) through graft polymerization. The result shows that 1-butanol fractionation is an effective method to improve the molecular weight homogeneity of lignin (PDI, 2.5 to 1.83) and increase the hydroxyl group content (0.585–1.793 mmol/g). The incorporation of BSL into the temperature-sensitive hydrogel can enhance the thermal stability and increase the hydrophobicity of the gel, which leads to a decrease in lower critical solution temperature (LCST). In addition, the compression strength, swelling ratio, and pore size of the gel can be adjusted by the dosage of lignin. This stimuli-responsive gel, with an LCST around 32 °C, is expected to be applied in the agricultural field as a pesticide carrier by stimulating release and absorption properties based on the change in natural environmental temperature.

scholarly journals Stimuli-Sensitive Hydrogel Based on N-Isopropylacrylamide and Itaconic Acid for Entrapment and Controlled Release ofCandida rugosaLipase under Mild Conditions

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Nikola Milašinović ◽  
Zorica Knežević-Jugović ◽  
Nedeljko Milosavljević ◽  
Marija Lučić Škorić ◽  
Jovanka Filipović ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Itaconic Acid ◽  
Candida Rugosa ◽  
Entrapment Efficiency ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Mild Conditions ◽  
The Matrix ◽  
Model Protein ◽  
Stimuli Sensitive

Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the matrix is enabled to protect the incorporated protein in the highly acidic environment of upper gastrointestinal tract and deliver it in the neutral or slightly basic region of the lower intestine. The protein/poly(NiPAAm-co-IA) hydrogels were synthetized by free radical crosslinking copolymerization and were characterized concerning their swelling capability, mechanical properties, and morphology. The pore structure and sizes up to 1.90 nm allowed good entrapment of lipase molecules. Model protein, lipase fromCandida rugosa,was entrapped within hydrogels upon mild conditions that provided its protection from harmful environmental influences. The efficiency of the lipase entrapment reached 96.7%, and was dependent on the initial concentration of lipase solution. The swelling of the obtained hydrogels in simulated pH and temperature of gastrointestinal tract, the lipase entrapment efficiency, and its release profiles from hydrogels were investigated as well.

scholarly journals Cooperatively assembled liquid crystals enable temperature-controlled Förster resonance energy transfer

2021 ◽  
Author(s):  
Zhen-Qiang Yu ◽  
Xiaodong Li ◽  
Wei Wan ◽  
Xin-Shun Li ◽  
Kuo Fu ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Nile Red ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Forster Resonance Energy Transfer ◽  
Optical Modulation ◽  
Förster Resonance Energy Transfer ◽  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Förster Resonance

A temperature-sensitive Förster resonance energy transfer system was constructed using a highly emissive liquid crystal co-assembled with Nile red, enabling thermo-optical modulation for controlling and directing light in stimuli-responsive devices.

Curcumin Loaded Ethosomal Gel for Improved Topical Delivery: Formulation, Characterization and Ex-vivo Studies

2021 ◽  
Vol 09 ◽  
Author(s):  
Bhumika Kumar ◽  
P.K. Sahoo ◽  
Satish Manchanda
Keyword(s):  
Transdermal Delivery ◽  
Smooth Surface ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Curcuma Longa ◽  
Research Work ◽  
Entrapment Efficiency ◽  
Active Constituent ◽  
Transdermal Penetration ◽  
Drug Solution

Background: Curcumin is a curcuminoid which is an active constituent of turmeric and is obtained from the rhizomes of Curcuma longa, family Zingiberaceae. Curcumin modulates the activity of various transcription factors and regulates the expression of inflammatory enzymes, cell survival proteins, adhesion molecules and cytokines by binding to a variety of proteins and inhibiting the activity of various kinases. Curcumin falls in the BCS class IV drug, with poor solubility and poor permeability which makes it very challenging in utilizing the maximum therapeutic potential of this moiety. Objective: The major aim of the study was to enhance transdermal penetration of curcumin via ethosomal gel and to overcome the barriers of poor permeability of transdermal drug delivery. Methods: Curcumin loaded ethosomes were prepared with varying quantities of ethanol and soya lecithin by cold method and were optimised based on entrapment efficiency, vesicular size and Ex-vivo studies. Optimised ethosomal formulation was further incorporated into a gel and was evaluated. Ex-vivo studies were performed with the ethosomal gel of curcumin and was compared with simple drug solution. Result: Prepared ethosomal system showed a vesicle size ranging from 211 to 320 nm with spherical, smooth surface and entrapment efficiency of 87 to 91%. Optimised ethosomal system (ET3) was incorporated into gel and was further evaluated. Conclusion: The findings of the research work suggested that the ethosomal gel holds an excellent potential for transdermal delivery of curcumin.

Microwave hyperthermia-responsible flexible liposomal gel as a novel transdermal delivery of methotrexate for enhanced rheumatoid arthritis therapy

2021 ◽  
Author(s):  
Qiying Shen ◽  
Ting Tang ◽  
Quan Hu ◽  
Xiaoying Ying ◽  
Gaofeng Shu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
Temperature Sensitive ◽  
Microwave Hyperthermia

Schematic of MTX-loaded temperature-sensitive flexible liposomal gel combined with microwave for treatment of RA.

Synthesis and Characterization of pH and Temperature-Sensitive Semi-IPN Hydrogels

2014 ◽  
Vol 1053 ◽  
pp. 224-230
Author(s):  
Shan Jiang ◽  
Xia Qian Li ◽  
Qiang Yu
Keyword(s):  
Temperature Sensitive ◽  
Stimuli Responsive ◽  
Swelling Properties ◽  
Dimethyl Ammonium ◽  
Swelling Rate ◽  
Ph And Temperature Sensitivity ◽  
Responsive Behavior ◽  
Radical Solution ◽  
Diallyl Dimethyl Ammonium Chloride

A series of novel cross-linked poly N-isopropylacrylamide (PNIPAM)/poly diallyl dimethyl ammonium chloride (PDMDAAC) semi-IPN hydrogels were synthesized through free radical solution polymerization in water at 30°C. FTIR was used to characterize the structure of resultant hydrogels. The pH and temperature sensitivity of hydrogels were systematicly studied, and the swelling properties of hydrogels were also explored. The results show that the semi-IPN hydrogels have both temperature and pH sensitivities. The hydrogels exhibit fast swelling rate and excellent stimuli-responsive behavior.

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