scholarly journals New Horizons in Hydrogels for Methotrexate Delivery

Gels ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. 2
Author(s):  
Ali Dehshahri ◽  
Anuj Kumar ◽  
Vijay Sagar Madamsetty ◽  
Ilona Uzieliene ◽  
Shima Tavakol ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Central Nervous System ◽  
Transdermal Delivery ◽  
State Of The Art ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
New Horizons ◽  
Poor Absorption ◽  
Plasma Half Life ◽  
Novel Delivery Systems

Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

Dimephosphone — vasoactive drug for normalization of nervous system function

1993 ◽  
Vol 74 (1) ◽  
pp. 8-12
Author(s):  
R. Kh. Khafizyaiiova ◽  
I. A. Studentsova ◽  
V. I. Danilov ◽  
I. S. Mokrinskaya ◽  
R. A. Garaev ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Experimental Study ◽  
Nervous System ◽  
Cerebral Circulation ◽  
Vasoactive Drug ◽  
System Function ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Clinical Tests ◽  
Nervous System Function

An experimental study of dimephpsphone, using different models of the disorders of cerebrum and cerebral circulation functions, reveals cerebroprotcctive properties and normalizing type of the effect on the regulating mechanisms of cerebral circulation. Clinical tests indicate the efficacy of the drug in different central nervous system diseases in neurological and neurosurgical clinics.

Trans Neuronal Retrograde Degeneration to OCT in Central Nervous System Diseases

2020 ◽  
pp. 365-374
Author(s):  
Bernardo F. Sánchez-Dalmau ◽  
Anna Camós-Carreras ◽  
Ruben Torres-Torres ◽  
Johannes Keller ◽  
Laura Sanchez-Vela ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Retrograde Degeneration

scholarly journals Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

2021 ◽  
Author(s):  
Gayatri Gopal Shetgaonkar ◽  
Shirleen Miriam Marques ◽  
Cleona E. M. DCruz ◽  
R. J. A. Vibhavari ◽  
Lalit Kumar ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Parenchyma ◽  
Brain Diseases ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker ◽  
Treatment And Diagnosis ◽  
The Brain

AbstractExosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. Graphical abstract

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