Cyclo-γ-Polyglutamic Acid-Coated Dual-Responsive Nanomicelles Loaded with Doxorubicin for Synergistic Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Chao Wang ◽  
Beilei Wang ◽  
Shuaijun Zou ◽  
Bo Wang ◽  
Guoyan Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Delivery Systems ◽  
Polyglutamic Acid ◽  
Nanodrug Delivery ◽  
Dual Responsive ◽  
Targeting Ability

Nanodrug delivery systems have been used extensively to improve the tumor-targeting ability and reduce the side effects of anticancer drugs. In this study, nanomicelles responsive to dual stimuli were designed...

Dual-responsive nanoplatform with feedback amplification improves antitumor efficacy of photodynamic therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yuan Xue ◽  
Shuting Bai ◽  
Leilei Wang ◽  
Shi Luo ◽  
Zhirong Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Tumor Cells ◽  
Delivery System ◽  
Antitumor Efficacy ◽  
Tumor Uptake ◽  
Dual Responsive ◽  
Intracellular Release ◽  
Enhance Efficiency

A good photosensitizer (PS) delivery system could enhance efficiency and reduce side effects of anti-tumor photodynamic therapy (PDT) by improving accumulation in tumor, uptake by tumor cells, and intracellular release...

scholarly journals Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7342
Author(s):  
Wei Liu ◽  
Xingqun Ma ◽  
Yingying Jin ◽  
Jie Zhang ◽  
Yang Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cells ◽  
Tumor Targeting ◽  
Laser Scanning ◽  
Water Solubility ◽  
Laser Scanning Microscopy ◽  
Chlorin E6 ◽  
Confocal Laser ◽  
Oxygen Generation ◽  
Targeting Ability

To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation. The singlet-oxygen generation rate of Ce6-biotin was slightly increased compared to Ce6. Flow cytometry and confocal laser scanning microscopy results confirmed Ce6-biotin had higher binding affinity toward biotin-receptor-positive HeLa human cervical carcinoma cells than its precursor, Ce6. Due to the BR-targeting ability of Ce6-biotin, it exhibited stronger cytotoxicity to HeLa cells upon laser irradiation. The IC50 against HeLa cells of Ce6-biotin and Ce6 were 1.28 µM and 2.31 µM, respectively. Furthermore, both Ce6-biotin and Ce6 showed minimal dark toxicity. The selectively enhanced therapeutic efficacy and low dark toxicity suggest that Ce6-biotin is a promising PS for BR-positive-tumor-targeting photodynamic therapy.

Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy

Nano Research ◽  
2014 ◽  
Vol 7 (9) ◽  
pp. 1291-1301 ◽  
Author(s):  
Nannan Wang ◽  
Zilong Zhao ◽  
Yifan Lv ◽  
Huanhuan Fan ◽  
Huarong Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Extracellular Ph ◽  
Gold Nanorod ◽  
Targeting Ability

Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

2016 ◽  
Vol 4 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Huaxia Shi ◽  
Wucheng Sun ◽  
Changbing Liu ◽  
Guiying Gu ◽  
Bo Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Tumor Growth ◽  
Cancer Diagnosis ◽  
Self Assembly ◽  
Tumor Targeting ◽  
Tumor Diagnosis

On-site activated diiodostyryl bodipy conjugated HA nanoparticles with specific targets synthesized via self-assembly were used for the suppression of tumor growth and exact tumor diagnosis with reduced side effects.

scholarly journals Double-layered hyaluronic acid/stearic acid-modified polyethyleneimine nanoparticles encapsulating (−)-gossypol: a nanocarrier for chiral anticancer drugs

2014 ◽  
Vol 2 (32) ◽  
pp. 5238-5248 ◽  
Author(s):  
Hao Liu ◽  
Ke Li ◽  
Lan Lan ◽  
Jingwen Ma ◽  
Yun Zeng ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Sustained Release ◽  
Stearic Acid ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Release Profile ◽  
Tumor Inhibition ◽  
Chiral Drug ◽  
Targeting Ability

The double-layered nanoparticles encapsulating the chiral drug (−)-gossypol possess tumor-targeting ability, a sustained release profile, and evident tumor-inhibition effects.

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

Fluorescence-guided magnetic nanocarriers for enhanced tumor targeting photodynamic therapy

2018 ◽  
Vol 6 (28) ◽  
pp. 4676-4686 ◽  
Author(s):  
Khalilalrahman Dehvari ◽  
Po-Ting Lin ◽  
Jia-Yaw Chang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Therapeutic Effects ◽  
Specific Targeting ◽  
Nir Imaging ◽  
Targeting Ability ◽  
Magnetic Nanocarriers ◽  
Subsequent Improvement

Fe3O4-HA-Ce6 nanotheranostic agents demonstrated specific targeting ability toward cancer cells with subsequent improvement in dual modal MR/NIR imaging and photodynamic therapeutic effects.

scholarly journals Utilisation of Targeted Nanoparticle Photosensitiser Drug Delivery Systems for the Enhancement of Photodynamic Therapy

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2628 ◽  
Author(s):  
Cherie Kruger ◽  
Heidi Abrahamse
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Tumour Cells ◽  
Cancer Drug ◽  
Ros Generation ◽  
Poor Treatment ◽  
Treatment Research

The cancer incidence world-wide has caused an increase in the demand for effective forms of treatment. One unconventional form of treatment for cancer is photodynamic therapy (PDT). PDT has 3 fundamental factors, namely a photosensitiser (PS) drug, light and oxygen. When a PS drug is administered to a patient, it can either passively or actively accumulate within a tumour site and once exposed to a specific wavelength of light, it is excited to produce reactive oxygen species (ROS), resulting in tumour destruction. However, the efficacy of ROS generation for tumour damage is highly dependent on the uptake of the PS in tumour cells. Thus, PS selective/targeted uptake and delivery in tumour cells is a crucial factor in PDT cancer drug absorption studies. Generally, within non-targeted drug delivery mechanisms, only minor amounts of PS are able to passively accumulate in tumour sites (due to the enhanced permeability and retention (EPR) effect) and the remainder distributes into healthy tissues, causing unwanted side effects and poor treatment prognosis. Thus, to improve the efficacy of PDT cancer treatment, research is currently focused on the development of specific receptor-based PS-nanocarrier platform drugs, which promote the active uptake and absorption of PS drugs in tumour sites only, avoiding unwanted side effects, as well as treatment enhancement. Therefore, the aim of this review paper is to focus on current actively targeted or passively delivered PS nanoparticle drug delivery systems, that have been previously investigated for the PDT treatment of cancer and so to deduce their overall efficacy and recent advancements.

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