Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy

2016 ◽  
Vol 4 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Huaxia Shi ◽  
Wucheng Sun ◽  
Changbing Liu ◽  
Guiying Gu ◽  
Bo Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Tumor Growth ◽  
Cancer Diagnosis ◽  
Self Assembly ◽  
Tumor Targeting ◽  
Tumor Diagnosis

On-site activated diiodostyryl bodipy conjugated HA nanoparticles with specific targets synthesized via self-assembly were used for the suppression of tumor growth and exact tumor diagnosis with reduced side effects.

Cyclo-γ-Polyglutamic Acid-Coated Dual-Responsive Nanomicelles Loaded with Doxorubicin for Synergistic Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Chao Wang ◽  
Beilei Wang ◽  
Shuaijun Zou ◽  
Bo Wang ◽  
Guoyan Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Delivery Systems ◽  
Polyglutamic Acid ◽  
Nanodrug Delivery ◽  
Dual Responsive ◽  
Targeting Ability

Nanodrug delivery systems have been used extensively to improve the tumor-targeting ability and reduce the side effects of anticancer drugs. In this study, nanomicelles responsive to dual stimuli were designed...

scholarly journals Prevalence and Management of Constipation and GI Diagnoses in Children With Solid Tumors

2021 ◽  
Author(s):  
Jennifer Belsky ◽  
Joseph R. Stanek ◽  
Nicholas D. Yeager ◽  
Daniel V. Runco
Keyword(s):  
Information System ◽  
Side Effects ◽  
Solid Tumors ◽  
Cancer Diagnosis ◽  
Solid Tumor ◽  
Health Information System ◽  
Tumor Diagnosis ◽  
Primary Study ◽  
Hospitalized Children ◽  
Gastrointestinal Complaint

Abstract Purpose Despite continued development of targeted therapies for children with cancer, patients continue to experience an array of unwanted side effects. Children with solid tumors may experience constipation as a result many treatment variables. Our objective was to investigate the prevalence and treatment of constipation in hospitalized children with solid tumors treated with chemotherapy. Methods We retrospectively analyzed data from 48 children’s hospitals in the Pediatric Health Information System, extracting patients 0–21 years of age with a solid tumor diagnosis hospitalized from October 2015-December 2019. Primary study outcome investigated which solid tumor subgroups received the diagnosis of constipation or received the most constipation medications while receiving chemotherapy for a cancer diagnosis. Results We identified 13,375 unique patients with a solid tumor diagnosis receiving chemotherapy. Constipation was the most common gastrointestinal complaint with 8,658 (64.7%; 95% Cl: 63.9–65.5%) meeting our defined constipation diagnosis. Bone cancers had the highest percentage (69.9%) of patients with constipation, while Hodgkin’s lymphoma had the lowest, though 52.1% of patients were affected. A total of 44% (n = 35,301) of encounters received an opioid at some point during admission. Of patients receiving constipation medications, the most commonly prescribed was poly-ethyl glycol (n = 25,175, 31.7%), followed by docusate (n = 11,297, 14.2%), senna (n = 10,325, 13.0%), and lactulose (n = 5,501, 6.9%). Conclusions Constipation is the most common gastrointestinal issue that children with solid tumors experience while receiving chemotherapy. Increased attention should be given to constipation prophylaxis and treatment in children with solid tumors undergoing chemotherapy.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis

2020 ◽  
Vol 20 (11) ◽  
pp. 1288-1299
Author(s):  
Paromita Kundu ◽  
Deepika Singh ◽  
Abhalaxmi Singh ◽  
Sanjeeb K. Sahoo
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Diagnosis ◽  
Specific Drug ◽  
Novel Therapies ◽  
Future Directions ◽  
Normal Tissues ◽  
Cancer Management ◽  
Single Probe ◽  
Therapy And Diagnosis

The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

Porphyrin-lipid nanovesicles (Porphysomes) are effective photosensitizers for photodynamic therapy

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Keegan Guidolin ◽  
Lili Ding ◽  
Juan Chen ◽  
Brian C. Wilson ◽  
Gang Zheng
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Intrinsic Structure ◽  
Therapeutic Applications ◽  
Positron Emission ◽  
Theranostic Agents ◽  
Negative Controls ◽  
And Control ◽  
Complete Tumor

Abstract Porphysomes (PS) are liposome-like nanoparticles comprising pyropheophorbide-conjugated phospholipids that have demonstrated potential as multimodal theranostic agents for applications that include phototherapies, targeted drug delivery and in vivo fluorescence, photoacoustic, magnetic resonance or positron emission imaging. Previous therapeutic applications focused primarily on photothermal therapy (PTT) and suggested that PSs require target-triggered activation for use as photodynamic therapy (PDT) sensitizers. Here, athymic nude mice bearing subcutaneous A549 human lung tumors were randomized into treatment and control groups: PS-PDT at various doses, PS-only and no treatment negative controls, as well as positive controls using the clinical photosensitizer Photofrin. Animals were followed for 30 days post-treatment. PS-PDT at all doses demonstrated a significant tumor ablative effect, with the greatest effect seen with 10 mg/kg PS at a drug-light interval of 24 h. By comparison, negative controls (PS-only, Photofrin-only, and no treatment) showed uncontrolled tumor growth. PDT with Photofrin at 5 mg/kg and PS at 10 mg/kg demonstrated similar tumor growth suppression and complete tumor response rates (15 vs. 25%, p = 0.52). Hence, porphysome nanoparticles are an effective PDT agent and have the additional advantages of multimodal diagnostic and therapeutic applications arising from their intrinsic structure. Porphysomes may also be the first single all-organic agent capable of concurrent PDT and PTT.

Microtubule-Targeted Self-Assembly Triggers Prometaphase–Metaphase Oscillations Suppressing Tumor Growth

Nano Letters ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 3052-3059
Author(s):  
Guanying Li ◽  
Xunwu Hu ◽  
Xia Wu ◽  
Ye Zhang
Keyword(s):  
Tumor Growth ◽  
Self Assembly

Rational fabrication of two-photon responsive metal-organic framework for enhanced photodynamic therapy

2021 ◽  
Author(s):  
Xin Yao ◽  
Xinxin Pei ◽  
Bo Li ◽  
Mengqi Lv ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Cancer Treatments ◽  
Two Photon ◽  
Metal Organic ◽  
Organic Framework

Rational design of specific platform which can address the unavoidable side effects of traditional cancer treatments is of great interest. In this sense, herein, an intelligent nanoplatform (ZnL1@MOF-199@FA) with efficient...

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

Sign in / Sign up

Export Citation Format

Share Document