Fluorescence-guided magnetic nanocarriers for enhanced tumor targeting photodynamic therapy

2018 ◽  
Vol 6 (28) ◽  
pp. 4676-4686 ◽  
Author(s):  
Khalilalrahman Dehvari ◽  
Po-Ting Lin ◽  
Jia-Yaw Chang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Therapeutic Effects ◽  
Specific Targeting ◽  
Nir Imaging ◽  
Targeting Ability ◽  
Magnetic Nanocarriers ◽  
Subsequent Improvement

Fe3O4-HA-Ce6 nanotheranostic agents demonstrated specific targeting ability toward cancer cells with subsequent improvement in dual modal MR/NIR imaging and photodynamic therapeutic effects.

scholarly journals Correction: Separately doped upconversion-C60 nanoplatform for NIR imaging-guided photodynamic therapy of cancer cells

2019 ◽  
Vol 55 (10) ◽  
pp. 1518-1518 ◽  
Author(s):  
Xiaomin Liu ◽  
Min Zheng ◽  
Xianggui Kong ◽  
Youlin Zhang ◽  
Qinghui Zeng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Nir Imaging ◽  
Photodynamic Therapy Of Cancer

Correction for ‘Separately doped upconversion-C60 nanoplatform for NIR imaging-guided photodynamic therapy of cancer cells’ by Xiaomin Liu et al., Chem. Commun., 2013, 49, 3224–3226.

Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

2017 ◽  
Vol 62 (1) ◽  
Author(s):  
Ranwei Li ◽  
Tiecheng Liu ◽  
Ke Wang
Keyword(s):  
Lung Cancer ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Zirconium Phosphate ◽  
Drug Loading ◽  
Lung Cancer Therapy ◽  
Targeting Ability ◽  
A549 Lung

AbstractNovel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%±4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity

scholarly journals Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7342
Author(s):  
Wei Liu ◽  
Xingqun Ma ◽  
Yingying Jin ◽  
Jie Zhang ◽  
Yang Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cells ◽  
Tumor Targeting ◽  
Laser Scanning ◽  
Water Solubility ◽  
Laser Scanning Microscopy ◽  
Chlorin E6 ◽  
Confocal Laser ◽  
Oxygen Generation ◽  
Targeting Ability

To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation. The singlet-oxygen generation rate of Ce6-biotin was slightly increased compared to Ce6. Flow cytometry and confocal laser scanning microscopy results confirmed Ce6-biotin had higher binding affinity toward biotin-receptor-positive HeLa human cervical carcinoma cells than its precursor, Ce6. Due to the BR-targeting ability of Ce6-biotin, it exhibited stronger cytotoxicity to HeLa cells upon laser irradiation. The IC50 against HeLa cells of Ce6-biotin and Ce6 were 1.28 µM and 2.31 µM, respectively. Furthermore, both Ce6-biotin and Ce6 showed minimal dark toxicity. The selectively enhanced therapeutic efficacy and low dark toxicity suggest that Ce6-biotin is a promising PS for BR-positive-tumor-targeting photodynamic therapy.

scholarly journals Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects

2018 ◽  
Author(s):  
Ivan Mfouo Tynga ◽  
Heidi Abrahamse
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Treatment Options ◽  
Therapeutic Effects ◽  
Drug Resistant ◽  
Severe Condition ◽  
Cell Niche ◽  
Extended Exposure

Deregulation of cell growth and development lead to cancer, a severe condition that claims millions of lives worldwide. Targeted or selective approaches used during cancer treatment determine the efficacy and outcome of the therapy. In order to enhance specificity and targeting and better treatment options for cancer, novel and alternative modalities are currently under development. Photodynamic therapy has the potential to eradicate cancer and combination therapy would yield even greater outcomes. Nanomedicine-aided cancer therapy shows enhanced specificity for cancer cells and minimal side-effects coupled with effective cancer destruction both in vitro and in vivo. Nanocarriers used in drug-delivery systems are well able to penetrate cancer stem cell niche, simultaneously killing cancer cells and eradicate drug-resistant cancer stem cells, yielding therapeutic efficiency up to 100 fold against drug-resistant cancer in comparison with free drugs. Safety precautions should be considered when using Nano-mediated therapy as the effects of extended exposure to biological environments are still to be determined.

scholarly journals An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer

2020 ◽  
Author(s):  
Guanchen Zhu ◽  
Kaikai Wang ◽  
Haixiang Qin ◽  
Xiaozhi Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Targeting Ability

Abstract Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment.Methods:The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated.Results:The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment.Conclusion:A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.

Cyclo-γ-Polyglutamic Acid-Coated Dual-Responsive Nanomicelles Loaded with Doxorubicin for Synergistic Chemo-Photodynamic Therapy

2021 ◽  
Author(s):  
Chao Wang ◽  
Beilei Wang ◽  
Shuaijun Zou ◽  
Bo Wang ◽  
Guoyan Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Delivery Systems ◽  
Polyglutamic Acid ◽  
Nanodrug Delivery ◽  
Dual Responsive ◽  
Targeting Ability

Nanodrug delivery systems have been used extensively to improve the tumor-targeting ability and reduce the side effects of anticancer drugs. In this study, nanomicelles responsive to dual stimuli were designed...

Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy

Nano Research ◽  
2014 ◽  
Vol 7 (9) ◽  
pp. 1291-1301 ◽  
Author(s):  
Nannan Wang ◽  
Zilong Zhao ◽  
Yifan Lv ◽  
Huanhuan Fan ◽  
Huarong Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Extracellular Ph ◽  
Gold Nanorod ◽  
Targeting Ability

Tumor targeting DVDMS-nanoliposomes for an enhanced sonodynamic therapy of gliomas

2019 ◽  
Vol 7 (3) ◽  
pp. 985-994 ◽  
Author(s):  
Yue Sun ◽  
Haiping Wang ◽  
Pan Wang ◽  
Kun Zhang ◽  
Xiaorui Geng ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Sonodynamic Therapy ◽  
Tumor Penetration ◽  
Specific Targeting ◽  
Targeting Ability

UTMD-assisted intelligent DVDMS encapsulate iRGD-Liposomes mediate SDT with deep tumor penetration and specific targeting ability enhanced anti-glioma efficacy.

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

iRGD Co-Administration with Paclitaxel-Loaded PLGA Nanoparticles Enhance Targeting and Antitumor Effect in Colorectal Cancer Treatment

2020 ◽  
Vol 20 ◽  
Author(s):  
Li Li ◽  
Mi Yang ◽  
Rutian Li ◽  
Jing Hu ◽  
Lixia Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Targeting ◽  
Antitumor Effect ◽  
Plga Nanoparticles ◽  
Specific Targeting ◽  
Cancer Models ◽  
Cell Experiment ◽  
Targeting Ability ◽  
Targeting Effect ◽  
Colorectal Cancer Treatment

Objective: To explore the targeting effect of PLGA-NP and iRGD co-administration with PTX-PLGA NP (PTX-PLGA + iRGD) on colorectal cancer. Methods: Whether PLGA-NP co-administration with iRGD peptide could show effective tumor-targeting ability in contrast to with PLGA-NP in colorectal cancer mice models was evaluated. Moreover, the chemotherapeutics paclitaxel (PTX) was loaded into the PLGA-NP to impart anti-tumor efficiency to the PTX-PLGA. Whether iRGD co-administration with PTX-PLGA NP (PTX-PLGA + iRGD) in colorectal cancer models enabled PTX to achieve better anti-tumor efficiency and biocompatibility was further assessed. Results: The targeting ability of PLGA-NP was enhanced in cell experiment and colorectal cancer mice models by coadministration of iRGD. As a result, PTX-PLGA + iRGD achieved better anti-tumor efficacy than PTX and PTX-PLGA. Conlusion: The nanocarrier based on PLGA with specific targeting ability could promote the clinical application of various chemotherapeutics similar to PTX. The combination of drug-loaded nanoparticles and iRGD could develop into a promising drug delivery system.

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