Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma

2021 ◽  
Author(s):  
Kyu Ri Kim ◽  
Su Jung You ◽  
Hyun Joo Kim ◽  
Dae Hyeok Yang ◽  
Heung Jae Chun ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Polymeric Nanoparticles ◽  
Synergistic Effects ◽  
Hybrid Nanoparticles ◽  
Specific Targeting ◽  
Self Assembled ◽  
Targeting Ability

Self-assembled theranostic hybrid nanoparticles containing dual drugs showed a specific targeting ability for breast carcinoma, and significantly reduced the tumor size due to the synergistic effects of the dual drugs.

Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs

2006 ◽  
Vol 6 (9) ◽  
pp. 3040-3047 ◽  
Author(s):  
Elisabetta E. Chiellini ◽  
Federica Chiellini ◽  
Roberto Solaro
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Polymeric Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Polymeric Systems ◽  
Nanoparticle Surface ◽  
Biological Tests ◽  
Targeting Ability ◽  
Average Size ◽  
Targeted Release

Significant efforts are being devoted to develop nanotechnology for drug delivery, mainly because of the distinct advantages offered by nanometer-size polymeric systems. Moreover, targeted drug delivery can be obtained by polymer conjugation to biospecific ligands. The present investigation was aimed mainly at determining the targeting ability of hybrid nanoparticles based on synthetic polymer/protein hybrid matrices. These nanoparticles were designed for liver targeted release of proteic drugs with antiviral activity, such as α-interferon. Human serum albumin and the monoesters of alternating copolymers of maleic anhydride/alkyl vinyl ethers of oligo(ethylene glycol) were selected as proteic and synthetic components, respectively. Digalactosyl diacyl glycerol, a natural glycolipid selectively recognized by the asialofetuin receptor present on liver hepatocytes was used as active targeting agent. Nanoparticles of 100–300 nm average size were obtained by controlled coprecipitation method. Investigation of nanoparticle surface properties by spectroscopic analysis and by biological tests indicated that the synthesized nanoparticles do expose on their surface targeting moieties that selectively interact with liver hepatocytes receptors.

scholarly journals In Vitro Cellular Uptake Studies of Self-Assembled Fluorinated Nanoparticles Labelled with Antibodies

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1906
Author(s):  
Mona Atabakhshi-Kashi ◽  
Mónica Carril ◽  
Hossein Mahdavi ◽  
Wolfgang J. Parak ◽  
Carolina Carrillo-Carrion ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cellular Uptake ◽  
Hydrophobic Interactions ◽  
Intrinsic Properties ◽  
Wide Range ◽  
Self Assembled ◽  
Uptake Studies ◽  
Targeting Ability ◽  
Fluorinated Nanoparticles

Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the internalization in cells via receptor-mediated endocytosis has been widely studied, the conjugation of antibodies to larger NP assemblies has been much less explored. Taking into account that NP assemblies may be advantageous for some specific applications, the possibility of incorporating targeting ligands is quite important. Herein, we performed the effective conjugation of antibodies onto a fluorescent NP assembly, which consisted of fluorinated Quantum Dots (QD) self-assembled through fluorine–fluorine hydrophobic interactions. Cellular uptake studies by confocal microscopy and flow cytometry revealed that the NP assembly underwent the same uptake procedure as individual NPs; that is, the antibodies retained their targeting ability once attached to the nanoassembly, and the NP assembly preserved its intrinsic properties (i.e., fluorescence in the case of QD nanoassembly).

Development of novel self-assembled poly(3-acrylamidophenylboronic acid)/poly(2-lactobionamidoethyl methacrylate) hybrid nanoparticles for improving nasal adsorption of insulin

Soft Matter ◽  
2012 ◽  
Vol 8 (3) ◽  
pp. 765-773 ◽  
Author(s):  
Cui Cheng ◽  
Xinge Zhang ◽  
Jixin Xiang ◽  
Yanxia Wang ◽  
Chao Zheng ◽  
...  
Keyword(s):  
Hybrid Nanoparticles ◽  
Self Assembled

Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma

Cancer ◽  
2002 ◽  
Vol 94 (5) ◽  
pp. 1383-1390 ◽  
Author(s):  
Aleodor A. Andea ◽  
Tracie Wallis ◽  
Lisa A. Newman ◽  
David Bouwman ◽  
Jyotirmoy Dey ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Lymph Node Status ◽  
Node Status ◽  
Pathologic Analysis

scholarly journals Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma

2002 ◽  
Vol 59 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Brano Topic ◽  
Nebojsa Stankovic ◽  
Dragutin Savjak ◽  
Slavko Grbic
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Size ◽  
Primary Tumor ◽  
Suppressor Gene ◽  
Nodal Status ◽  
Primary Tumor Size ◽  
Tumor Suppressor Gene P53

Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.

scholarly journals Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington’s disease

2020 ◽  
Author(s):  
Giulia Birolini ◽  
Marta Valenza ◽  
Ilaria Ottonelli ◽  
Alice Passoni ◽  
Monica Favagrossa ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Polymeric Nanoparticles ◽  
Cholesterol Biosynthesis ◽  
Hybrid Nanoparticles ◽  
Neural Cells ◽  
Peripheral Tissues ◽  
Brain Cholesterol ◽  
The Brain

AbstractSupplementing brain cholesterol is emerging as a potential treatment for Huntington’s disease (HD), a genetic neurodegenerative disorder characterized, among other abnormalities, by inefficient brain cholesterol biosynthesis. However, delivering cholesterol to the brain is challenging due to the bloodbrain barrier (BBB), which prevents it from reaching the striatum, especially, with therapeutically relevant doses.Here we describe the distribution, kinetics, release, and safety of novel hybrid polymeric nanoparticles made of PLGA and cholesterol which were modified with an heptapeptide (g7) for BBB transit (hybrid-g7-NPs-chol). We show that these NPs rapidly reach the brain and target neural cells. Moreover, deuterium-labeled cholesterol from hybrid-g7-NPs-chol is released in a controlled manner within the brain and accumulates over time, while being rapidly removed from peripheral tissues and plasma. We confirm that systemic and repeated injections of the new hybrid-g7-NPs-chol enhanced endogenous cholesterol biosynthesis, prevented cognitive decline, and ameliorated motor defects in HD animals, without any inflammatory reaction.In summary, this study provides insights about the benefits and safety of cholesterol delivery through advanced brain-permeable nanoparticles for HD treatment.

Induced Circular Dichroism of Gold in the Self-Assembled Polymeric Nanoparticles

2010 ◽  
Vol 10 (5) ◽  
pp. 3551-3556 ◽  
Author(s):  
Mi-Kyong Yoo ◽  
Min-Yim Park ◽  
Sang-Wha Lee ◽  
Yun-Jaie Choi ◽  
In-Kyu Park ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Polymeric Nanoparticles ◽  
The Self ◽  
Induced Circular Dichroism ◽  
Self Assembled ◽  
Circular Dichroïsm

Self-assembled tacrolimus-loaded lecithin-chitosan hybrid nanoparticles for in vivo management of psoriasis

2021 ◽  
pp. 121114
Author(s):  
Salma A. Fereig ◽  
Ghada M. El-Zaafarany ◽  
Mona G. Arafa ◽  
Mona M.A. Abdel-Mottaleb
Keyword(s):  
Hybrid Nanoparticles ◽  
Self Assembled
Sign in / Sign up

Export Citation Format

Share Document