Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma

Cancer ◽  
2002 ◽  
Vol 94 (5) ◽  
pp. 1383-1390 ◽  
Author(s):  
Aleodor A. Andea ◽  
Tracie Wallis ◽  
Lisa A. Newman ◽  
David Bouwman ◽  
Jyotirmoy Dey ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Lymph Node Status ◽  
Node Status ◽  
Pathologic Analysis

scholarly journals The effect of tumor size and lymph node status on breast carcinoma lethality

Cancer ◽  
2003 ◽  
Vol 98 (10) ◽  
pp. 2133-2143 ◽  
Author(s):  
James S. Michaelson ◽  
Melvin Silverstein ◽  
Dennis Sgroi ◽  
Justin A. Cheongsiatmoy ◽  
Alphonse Taghian ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Lymph Node Status ◽  
Node Status

scholarly journals Disruption of the expected positive correlation between breast tumor size and lymph node status inBRCA1-related breast carcinoma

Cancer ◽  
2003 ◽  
Vol 98 (8) ◽  
pp. 1569-1577 ◽  
Author(s):  
William D. Foulkes ◽  
Kelly Metcalfe ◽  
Wedad Hanna ◽  
Henry T. Lynch ◽  
Parviz Ghadirian ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Breast Tumor ◽  
Lymph Node Status ◽  
Positive Correlation ◽  
Node Status

scholarly journals TYPE OF ARTICLE: ORIGINAL ARTICLE ROLE OF CYTOKERATIN BIOMARKERS IN BREAST CARCINOMA

2016 ◽  
Vol 9 (6) ◽  
pp. 293
Author(s):  
Ritu Yadav
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Hormone Receptor ◽  
Research Work ◽  
Tumor Grade ◽  
Lymph Node Status ◽  
Node Status ◽  
Number Of Patients

 ABSTRACT:Objective:Breast cancer comprises different biological subtypes having varied spectrum of clinical and pathological features with different prognostic and therapeutic implications. This study aimed at the identification of patients on the basis of cancer biomarkers and various clinicopathological parameters.Methods: Fresh paraffin embedded tissue block sample of three hundred fifty patients of breast carcinoma were collected during 2011-2014, from the Pathology department, Pt. B.D Sharma University of Heath Sciences Rohtak, Haryana and studied in detail to determine the correlation between hormone receptor status /cytokeratin (CK) expression along with clinicopathologicalfactors.Theimmunohistochemical assay of three hundred fifty patients of breast cancer was performed.Maximum number of patients (35%) were found in the age group of <40 years. Most of the patients were observed with the grade I (59%), tumor size 2-4.9cm (45%), <4 positive lymph node status for metastasis andinfiltrate ductal carcinoma type (93%).Triple positive and triple negative breast cancer types were studiedto identify the basal and luminal phenotypes on the basis of markers CK5, 14 and CK8/18 expression.Results:The expression of CK5 &14 was found to be significantly associated with tumor grade (P=0.001 and P=0.0001), tumor size (P= 0.001) respectively.Whereas CK8/18 expression did not reveal any significant association with tumor grade,size, lymph node status and histological type of breast carcinoma.Conclusion:In conclusion the prognostic and therapeutic value of research work would be examined and validated further on larger number of samples.Keywords: Breast carcinoma, biomarkers, clinicopathological factors, Cytokeratin, hormone receptor 

Sentinel Node Status and Tumor Characteristics: A Study of 234 Invasive Breast Carcinomas

2005 ◽  
Vol 129 (1) ◽  
pp. 82-84 ◽  
Author(s):  
Ying Cao ◽  
Gladell P. Paner ◽  
Prabha B. Rajan
Keyword(s):  
Lymph Node ◽  
Tumor Size ◽  
Lymphovascular Invasion ◽  
Frozen Section ◽  
Paraffin Section ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Breast Carcinomas ◽  
Node Status ◽  
Size Grade

Abstract Context.—Axillary lymph node status is the most important prognostic factor in patients with breast cancer. Tumor size and lymph node status, the most reliable pathologic bases of the tumor staging system, are practical parameters for estimating survival status. With the advent of lymphatic mapping and sentinel node (SN) identification, there is potential for a more efficient and sensitive evaluation of the axillary lymph node status. Objective.—To correlate SN status with tumor size, grade, and lymphovascular invasion. Design.—We examined 234 patients with unifocal breast carcinomas measuring 25 mm or less as detected by preoperative ultrasound during the period May 1998 through December 2002. Sentinel nodes were examined by frozen section and paraffin section as per protocol. Results.—Of the 234 patients, SN was identified in 221 (94.5%). An average of 1.38 SNs were examined per patient. Seventy-seven of 221 patients were SN positive on paraffin section. Sixty-six (85.7%) of these 77 cases could be correctly diagnosed as positive for metastatic carcinoma on frozen section. Two cases reported as positive on paraffin section were reported as suspicious on frozen section. Logistic regression indicated that tumor size, grade, and lymphovascular invasion were all significantly associated with SN status (P &lt; .001). Conclusions.—Tumor size, grade, and lymphovascular invasion were significantly associated with SN status in unifocal invasive breast carcinoma.

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