Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs

2006 ◽  
Vol 6 (9) ◽  
pp. 3040-3047 ◽  
Author(s):  
Elisabetta E. Chiellini ◽  
Federica Chiellini ◽  
Roberto Solaro
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Polymeric Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Polymeric Systems ◽  
Nanoparticle Surface ◽  
Biological Tests ◽  
Targeting Ability ◽  
Average Size ◽  
Targeted Release

Significant efforts are being devoted to develop nanotechnology for drug delivery, mainly because of the distinct advantages offered by nanometer-size polymeric systems. Moreover, targeted drug delivery can be obtained by polymer conjugation to biospecific ligands. The present investigation was aimed mainly at determining the targeting ability of hybrid nanoparticles based on synthetic polymer/protein hybrid matrices. These nanoparticles were designed for liver targeted release of proteic drugs with antiviral activity, such as α-interferon. Human serum albumin and the monoesters of alternating copolymers of maleic anhydride/alkyl vinyl ethers of oligo(ethylene glycol) were selected as proteic and synthetic components, respectively. Digalactosyl diacyl glycerol, a natural glycolipid selectively recognized by the asialofetuin receptor present on liver hepatocytes was used as active targeting agent. Nanoparticles of 100–300 nm average size were obtained by controlled coprecipitation method. Investigation of nanoparticle surface properties by spectroscopic analysis and by biological tests indicated that the synthesized nanoparticles do expose on their surface targeting moieties that selectively interact with liver hepatocytes receptors.

scholarly journals Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

2021 ◽  
Vol 12 ◽  
Author(s):  
Agnese Gagliardi ◽  
Elena Giuliano ◽  
Eeda Venkateswararao ◽  
Massimo Fresta ◽  
Stefania Bulotta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Chemical Properties ◽  
Anticancer Compounds ◽  
Polymeric Systems ◽  
Physico Chemical ◽  
Specific Tumor ◽  
Tumor Tissues ◽  
Therapeutic Molecules ◽  
Biopharmaceutical Properties

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.

scholarly journals Lung-targeted Macrophage Biomimetic Nanocarriers Based on Platycodon Grandiflorum Polysaccharides for Calming Cytokine Storm in Pneumonia

2021 ◽  
Author(s):  
Yi Li ◽  
Chunjing Guo ◽  
Qiang Chen ◽  
Yanguo Su ◽  
Huimin Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Severe Pneumonia ◽  
Scientific Basis ◽  
Cytokine Storm ◽  
Platycodon Grandiflorum ◽  
Life Threatening ◽  
Targeting Ability ◽  
Delivery Efficiency

Abstract Background Pneumonia is a life-threatening respiratory disease without effective treatment due to uncontrolled inflammation of the lung tissue. Suppression of cytokine storms may be one of the keys to saving the lives of patients with severe pneumonia. Given the fragile delivery efficiency of drugs in vivo, novel delivery platforms to address these issues are necessary. Results Here, we developed a biomimetic nanocarrier (MNPs) with macrophage membranes coated ROS-responsive Platycodon grandiflorum polysaccharides nanoparticles (PNPs) for targeted delivery of curcumin (MNPs@Cur) to inflamed lungs and treat inflammation by calming cytokine storms. In the study, we could clearly find that MNPs@Cur significantly attenuated inflammation and cytokine storm syndrome in acute lung injury (ALI) mice by neutralizing multiple proinfammatory cytokines. Interestingly, we found that the PNPs also had potent pulmonary targeting compared to other polysaccharide carriers, which probably means that PNPs have inherited the natural targeting ability in the medicinal guide theory of Traditional Chinese Medicine (TCM). Conclusion The results demonstrated that the developed drug delivery system may serve as an effective and safe nanoplatform for the treatment of pneumonia, as well as provide experimental scientific basis for the medicinal guide theory of TCM and its clinical application.

scholarly journals Acupoint Nanocomposite Hydrogel for Simulation of Acupuncture and Targeted Delivery of Triptolide Against Rheumatoid Arthritis

2021 ◽  
Author(s):  
Shujing Ren ◽  
Heng Liu ◽  
Xitong Wang ◽  
Jiquan Bi ◽  
Shengfeng Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Targeted Delivery ◽  
Pain Threshold ◽  
Modern Medicine ◽  
Inflammatory Factors ◽  
Nanocomposite Hydrogel ◽  
Analgesic Effects ◽  
Anti Inflammatory ◽  
Targeting Ability

Abstract BackgroundAttenuating the inflammatory response and relieving pain are two therapeutical goals for rheumatoid arthritis (RA). Anti-inflammatory and analgesic drugs are often associated with many adverse effects due to nonspecific distribution. New drug delivery systems with effective targeting ability and other complementary strategies are on urgent need to be explored. To achieve this goal, an acupoint drug delivery system that can simulate acupuncture in relieving pain and targeted deliver anti-inflammatory drugs is constructed, which can co-deliver 2-chloro-N (6)-cyclopentyl adenosine (CCPA) and triptolide (TP). ResultsWe have successfully demonstrated that the nanocomposite hydrogel composed of TP-Human serum album nanoparticles (HSA NPs) and CCPA could effectively treat the RA. We found that this combination therapy can enhance analgesic effects while the mechanical pain threshold was 5.2 times compared with model group, and the thermal pain threshold was 1.4 times. Acupoint nanocomposite hydrogel could not only improve the accumulation of the designed nanomedicine in arthritic paws (13.5% higher than those in non-acupoint at 48h), but also cooperate with nanomedicine to exert synergetic improvement of inflammation and reduction of systemic toxicity. Furthermore, it can regulate inflammatory factors and restore the balance of Th17/Treg cell which provide a novel effective treatment strategy for RA.ConclusionThis novel therapeutic approach-acupoint nanocomposite hydrogel, builds a bridge between acupuncture and drugs which sheds light on the combination of traditional and modern medicine.

Au Nanoparticle-Decorated TiO2 Nanospheres Produced by Laser Reshaping in Water

2020 ◽  
Vol 312 ◽  
pp. 113-120
Author(s):  
Stanislav O. Gurbatov ◽  
Sergei A. Kulinich ◽  
Aleksandr A. Kuchmizhak
Keyword(s):  
Hybrid Nanostructures ◽  
Hybrid Nanoparticles ◽  
Au Nanoparticle ◽  
Chloroauric Acid ◽  
Au Nanoclusters ◽  
X Ray ◽  
Nanoparticle Surface ◽  
Average Size ◽  
New Generation ◽  
532 Nm

Here, we demonstrate formation of spherical-shaped amorphous titania (TiO2) nanoparticles decorated with Au nanoclusters via nanosecond pulse ablation (7-ns, 532-nm wavelength) of commercially available TiO2 nanopowders dispersed in an aqueous solution of chloroauric acid (HAuCl4). Generation of such hybrid nanostructures was found to be caused by laser-induced remelting of the initial TiO2 nanoparticles, stimulated by Au nanoclusters that can adsorbed on their surface and boost light-to-heat conversion process in optically transparent titania. The morphology and chemical composition of the obtained hybrid nanomaterials were studied in detail via scanning electron microscopy, Raman spectroscopy and Energy Dispersive X-ray spectroscopy. The average size and number of Au nanoclusters reduced on the TiO2 nanoparticle surface was shown to be tuned by varying the initial nanoparticles/HAuCl4 concentration ratio. Spectroscopic measurements of single hybrid nanoparticles scattering, as well as the corresponding numerical calculations of electromagnetic fields structure near their surface indicate synthesized functional nanomaterials as extremely promising for numerous applications of modern optics, optoelectronics and nanophotonics, e.g., realization of advanced chemo-and biosensing platforms, as well as of new-generation solar cells.

Theranostic potential of biodegradable polymeric nanoparticles with paclitaxel and curcumin against breast carcinoma

2021 ◽  
Author(s):  
Kyu Ri Kim ◽  
Su Jung You ◽  
Hyun Joo Kim ◽  
Dae Hyeok Yang ◽  
Heung Jae Chun ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Tumor Size ◽  
Polymeric Nanoparticles ◽  
Synergistic Effects ◽  
Hybrid Nanoparticles ◽  
Specific Targeting ◽  
Self Assembled ◽  
Targeting Ability

Self-assembled theranostic hybrid nanoparticles containing dual drugs showed a specific targeting ability for breast carcinoma, and significantly reduced the tumor size due to the synergistic effects of the dual drugs.

scholarly journals Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1967
Author(s):  
Ziwen Dai ◽  
Juan Li ◽  
Yongfang Lin ◽  
Zhigang Wang ◽  
Yang Huang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Dna Aptamers ◽  
Dna Nanostructures ◽  
Dna Strands ◽  
Targeting Ability

We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease.

Folate-containing reduction-sensitive lipid–polymer hybrid nanoparticles for targeted delivery of doxorubicin

2015 ◽  
Vol 3 (4) ◽  
pp. 655-664 ◽  
Author(s):  
Bo Wu ◽  
Ping Yu ◽  
Can Cui ◽  
Ming Wu ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Outer Layer ◽  
Targeted Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Lipid–polymer hybrid nanoparticles (FLPNPs) containing a folate targeted ligand and a reduction-sensitive outer layer were developed to enhance drug delivery efficacy in vitro and in vivo.

A modular and orthogonally reactive platform for fabrication of polymer–drug conjugates for targeted delivery

2020 ◽  
Vol 11 (45) ◽  
pp. 7137-7146
Author(s):  
Mehmet Arslan ◽  
Burcu Sumer Bolu ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Therapeutic Agents ◽  
Polymeric Systems ◽  
Drug Conjugates ◽  
Targeted Drug ◽  
Polymer Drug Conjugates

Increasing interest in utilization of polymeric systems in targeted drug delivery has necessitated fabrication of polymers that undergo facile functionalization with targeting groups and therapeutic agents in a modular and orthogonal fashion.

Current Developments in Targeted Drug Delivery Systems for Glioma

2020 ◽  
Vol 26 (32) ◽  
pp. 3973-3984 ◽  
Author(s):  
Dhrumi Patel ◽  
Sarika Wairkar ◽  
Mayur C. Yergeri
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Adult Population ◽  
Delivery Systems ◽  
The Body ◽  
Hybrid Nanoparticles ◽  
Clinical Practices ◽  
Post Surgery ◽  
Targeted Drug

Background: Glioma is one of the most commonly observed tumours, representing about 75% of brain tumours in the adult population. Generally, glioma treatment includes surgical resection followed by radiotherapy and chemotherapy. The current chemotherapy for glioma involves the use of temozolomide, doxorubicin, monoclonal antibodies, etc. however, the clinical outcomes in patients are not satisfactory. Primarily, the blood-brain barrier hinders these drugs from reaching the target leading to the recurrence of glioma post-surgery. In addition, these drugs are not target-specific and affect the healthy cells of the body. Therefore, glioma-targeted drug delivery is essential to reduce the rate of recurrence and treat the condition with more reliable alternatives. Methods: A literature search was conducted to understand glioma pathophysiology, its current therapeutic approaches for targeted delivery using databases like Pub Med, Web of Science, Scopus, and Google Scholar, etc. Results: This review gives an insight to challenges associated with current treatments, factors influencing drug delivery in glioma, and recent advancements in targeted drug delivery. Conclusion: The promising results could be seen with nanotechnology-based approaches, like polymeric, lipidbased, and hybrid nanoparticles in the treatment of glioma. Biotechnological developments, such as carrier peptides and gene therapy, are future prospects in glioma therapy. Therefore, these targeted delivery systems will be beneficial in clinical practices for glioma treatment.

Surface modified polymeric nanoparticles for drug delivery: preparation and applications

2020 ◽  
Vol 14 ◽  
Author(s):  
Garima Joshi ◽  
Krutika Sawant ◽  
Mitali Patel ◽  
Deepak Chaudhary
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Surface Engineering ◽  
Polymeric Nanoparticles ◽  
Biochemical Properties ◽  
Site Of Action ◽  
Hiv Drugs ◽  
Surface Modified ◽  
Surface Modified Nanoparticles ◽  
Anti Hiv

: Nanotechnology is one of the emerging fields in the drug delivery for targeting the drug to the site of action. The polymeric nanoparticles as drug delivery systems have gained importance for the last few decades. They offer advantages over liposomes, dendrimers, emulsions etc. Surface engineering of polymeric nanoparticles is widely utilized to effectively target the cells in various diseases such as cancer, HIV infection. Surface modified nanoparticles offer various advantages such as targeted drug delivery, reduction in side effects, dose reductionand improved therapeutic efficacy. Moreover, they can aid in improving physical and biochemical properties, pharmacokinetic and pharmacodynamic profiles of drug. Surface modified polymeric nanoparticles can provide targeted delivery of drugs into specific cells, especially when targets are intracellular localized. This approach would be more advantageous for the delivery of various anticancer, anti inflammatory, anti HIV drugs for more effective therapy. This review focuses on the techniques used for fabrication of polymeric nanoparticles, material used for surface modification and their applications.

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