A new near-infrared phosphorescent iridium(III) complex conjugated to an xanthene dye for mitochondria-targeted photodynamic therapy

2021 ◽  
Author(s):  
Yongquan Wu ◽  
Jie Wu ◽  
Wai-Yeung Raymond Wong

Iridium(III) complexes are potent candidates for photodynamic therapy (PDT), but some key drawbacks still hamper clinical translation, such as poor operability in the phototherapeutic window, high dark toxicity, and low...

2019 ◽  
Vol 55 (30) ◽  
pp. 4343-4346 ◽  
Author(s):  
Xuan Wu ◽  
Yong Chen ◽  
Qilin Yu ◽  
Feng-Qing Li ◽  
Yu Liu

A ternary supramolecular assembly with near-infrared lysosome imaging and targeted photodynamic therapy properties was successfully orthogonally constructed in a two-step assembly manner.


Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.


2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.


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