A novel cell membrane-targeting fluorescent probe for imaging endogenous/exogenous formaldehyde in live cells and zebrafish

The Analyst ◽  
2021 ◽  
Author(s):  
Wenlong Sheng ◽  
Xue Zhang ◽  
Miaohui Yu ◽  
Meng Jin ◽  
Ning Li ◽  
...  
Keyword(s):  
Economic Development ◽  
Cell Membrane ◽  
Human Health ◽  
Fluorescent Probe ◽  
Live Cells ◽  
Membrane Targeting ◽  
Health It ◽  
Global Pollutant

Formaldehyde (FA) is not only an economic chemical but also a global pollutant. Although it brings economic development, it poses a threat to human health. It is also a kind...

A near-infrared fluorescent probe targeting mitochondria for sulfite detection and its application in food and biology

2021 ◽  
Author(s):  
Jianbin Chao ◽  
Zhuo Wang ◽  
Yongbin Zhang ◽  
Fangjun Huo ◽  
Caixia Yin
Keyword(s):  
Cardiovascular Diseases ◽  
Sulfur Dioxide ◽  
Human Health ◽  
Fluorescent Probe ◽  
Respiratory Diseases ◽  
Near Infrared ◽  
Air Pollutant ◽  
Great Harm

Abstract: Sulfur dioxide (SO2) is the main air pollutant in the environment, causing great harm to human health. Abnormal SO2 levels are usually associated with some respiratory diseases, cardiovascular diseases,...

Turn-on fluorescent probe for dopamine detection in solutions and live cells based on in situ formation of aminosilane-functionalized carbon dots

2021 ◽  
Vol 1157 ◽  
pp. 338394
Author(s):  
Xiao-Yue Tang ◽  
Yi-Ming Liu ◽  
Xiao-Lin Bai ◽  
Hao Yuan ◽  
Yi-Kao Hu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Carbon Dots ◽  
Live Cells ◽  
Turn On ◽  
Dopamine Detection ◽  
In Situ Formation

scholarly journals A Risk Assessment for Ozone Regulation Based on Statistical Rollback

2021 ◽  
Vol 11 (5) ◽  
pp. 2388
Author(s):  
Yongku Kim ◽  
Jeongjin Lee
Keyword(s):  
Public Health ◽  
Risk Assessment ◽  
Human Health ◽  
Air Pollutants ◽  
Hierarchical Bayesian Models ◽  
Health It ◽  
Matching Method ◽  
Regulatory Standards ◽  
Ozone Regulation ◽  
Ozone Levels

In environmental studies, it is important to assess how regulatory standards for air pollutants affect public health. High ozone levels contribute to harmful air pollutants. The EPA regulates ozone levels by setting ozone standards to protect public health. It is thus crucial to assess how various regulatory ozone standards affect non-accidental mortality related to respiratory deaths during the ozone season. The original rollback approach provides an adjusted ozone process under a new regulation scenario in a deterministic fashion. Herein, we consider a statistical rollback approach to allow for uncertainty in the rollback procedure by adopting the quantile matching method so that it provides flexible rollback sets. Hierarchical Bayesian models are used to predict the potential effects of different ozone standards on human health. We apply the method to epidemiologic data.

A water-soluble boronate masked benzoindocyanin fluorescent probe for the detection of endogenous mitochondrial peroxynitrite in live cells and zebrafish as inflammation models

2021 ◽  
pp. 109371
Author(s):  
Prasad M. Sonawane ◽  
Tesla Yudhistira ◽  
Mahesh B. Halle ◽  
Arkaprava Roychaudhury ◽  
Yunsu Kim ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Water Soluble ◽  
Live Cells

scholarly journals A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells

Biochemistry ◽  
2017 ◽  
Vol 57 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Tian Qiu ◽  
Rahul S. Kathayat ◽  
Yang Cao ◽  
Michael W. Beck ◽  
Bryan C. Dickinson
Keyword(s):  
Fluorescent Probe ◽  
Water Solubility ◽  
Protein S ◽  
Live Cells

scholarly journals Monomer–dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies

2007 ◽  
Vol 179 (5) ◽  
pp. 1067-1082 ◽  
Author(s):  
Valeria R. Caiolfa ◽  
Moreno Zamai ◽  
Gabriele Malengo ◽  
Annapaola Andolfo ◽  
Chris D. Madsen ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cell Surface ◽  
Plasminogen Activator ◽  
Fluorescent Protein ◽  
Surface Protein ◽  
Basal Membrane ◽  
Membrane Dynamics ◽  
Live Cells ◽  
Cell Surface Protein ◽  
Protein Assemblies

To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer–oligomer exchange and membrane dynamics and confinement, we studied urokinase plasminogen activator (uPA) receptor (uPAR), a GPI receptor involved in the regulation of cell adhesion, migration, and proliferation. Using a functionally active fluorescent protein–uPAR in live cells, we analyzed the effect that extracellular matrix proteins and uPAR ligands have on uPAR dynamics and dimerization at the cell membrane. Vitronectin directs the recruitment of dimers and slows down the diffusion of the receptors at the basal membrane. The commitment to uPA–plasminogen activator inhibitor type 1–mediated endocytosis and recycling modifies uPAR diffusion and induces an exchange between uPAR monomers and dimers. This exchange is fully reversible. The data demonstrate that cell surface protein assemblies are important in regulating the dynamics and localization of uPAR at the cell membrane and the exchange of monomers and dimers. These results also provide a strong rationale for dynamic studies of GPI-anchored molecules in live cells at steady state and in the absence of cross-linker/clustering agents.

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