A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

2021 ◽  
Author(s):  
Bochao Chen ◽  
Shumei Mao ◽  
Yanyan Sun ◽  
Liyuan Sun ◽  
Ning Ding ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Diabetic Mouse ◽  
Living Cells ◽  
Pancreatic Tissue ◽  
Diabetic Mice ◽  
Mice Model ◽  
Viscosity Changes

A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes, which was applied to detect the intracellular viscosity and imagine pancreatic tissue in diabetic mouse model.

scholarly journals Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

2018 ◽  
Vol 9 (33) ◽  
pp. 6758-6764 ◽  
Author(s):  
Mingwang Yang ◽  
Jiangli Fan ◽  
Junwei Zhang ◽  
Jianjun Du ◽  
Xiaojun Peng
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Diabetic Mice ◽  
Mice Model ◽  
Two Photon

A 1,8-naphthalimide-based two-photon fluorescent probe was designed to visualize MGO levels in living cells and a diabetic mice model.

A novel hydrosoluble near-infrared fluorescent probe for specifically monitoring tyrosinase and application in a mouse model

2019 ◽  
Vol 55 (64) ◽  
pp. 9463-9466 ◽  
Author(s):  
Jiahang Zhang ◽  
Zhao Li ◽  
Xinwei Tian ◽  
Ning Ding
Keyword(s):  
Mouse Model ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells

A novel hydrosoluble near-infrared fluorescent probe is applied to imaging and detection of endogenous tyrosinase in living cells, zebrafish and a mouse model.

A smart mitochondria-targeting TP-NIR fluorescent probe for selective and sensitive sensing H2S in living cells and mice

2021 ◽  
Author(s):  
Qiaomei Yang ◽  
Liyi Zhou ◽  
Longpeng Peng ◽  
Gangqiang Yuan ◽  
Haiyuan Ding ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Signal Molecules ◽  
Two Photon ◽  
Mitochondria Targeting

Hydrogen sulfide (H2S) is one of the important gaseous signal molecules and plays key roles in various biologically crucial processes. In this work, we report a novel two-photon near-infrared (TP-NIR)...

scholarly journals Near-infrared fluorescent probe for sensitive detection of Pb(II) ions in living cells

2017 ◽  
Vol 468 ◽  
pp. 140-145 ◽  
Author(s):  
Jianheng Bi ◽  
Mingxi Fang ◽  
Jianbo Wang ◽  
Shuai Xia ◽  
Yibin Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Sensitive Detection

Near-infrared templated fluorescent probe for nitroxyl: Selective and sensitive turn-on detection in living cells

2020 ◽  
Vol 310 ◽  
pp. 127839 ◽  
Author(s):  
Sathyadevi Palanisamy ◽  
Li-Fong Chen ◽  
Shey-Cherng Tzou ◽  
Yun-Ming Wang
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Turn On

The Synthesis of a Novel Near-Infrared Fluorescent Probe and its Application in Imaging of Living Cells

2014 ◽  
Vol 175 (3) ◽  
pp. 1644-1650 ◽  
Author(s):  
Chunlong Sun ◽  
Jin Cai ◽  
Junqing Chen ◽  
Yang Wu ◽  
Peng Wang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells

A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals

2018 ◽  
Vol 6 (27) ◽  
pp. 4466-4473 ◽  
Author(s):  
Junfeng Miao ◽  
Yingying Huo ◽  
Hu Shi ◽  
Junru Fang ◽  
Juanjuan Wang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Tertiary Amine ◽  
Near Infrared ◽  
Living Cells ◽  
Amine Functionalized ◽  
Rhodamine Dye

An aromatic tertiary amine-functionalized Si-rhodamine dye has been exploited as a near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and mice.

Softened food reduces weight loss in the streptozotocin-induced male mouse model of diabetic nephropathy

2018 ◽  
Vol 52 (4) ◽  
pp. 373-383 ◽  
Author(s):  
Sisse A Nørgaard ◽  
Fredrik W Sand ◽  
Dorte B Sørensen ◽  
Klas SP Abelson ◽  
Henrik Søndergaard
Keyword(s):  
Weight Loss ◽  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Diabetic Mouse ◽  
Diabetic Mice ◽  
Reduce Weight Loss ◽  
Normal Chow ◽  
Corticosterone Metabolites ◽  
Reducing Stress ◽  
Humane Endpoint

The streptozotocin (STZ)-induced diabetic mouse is a widely used model of diabetes and diabetic nephropathy (DN). However, it is a well-known issue that this model is challenged by high weight loss, which despite supportive measures often results in high euthanization rates. To overcome these issues, we hypothesized that supplementing STZ-induced diabetic mice with water-softened chow in addition to normal chow would reduce weight loss, lower the need for supportive treatment, and reduce the number of mice reaching the humane endpoint of 20% weight loss. In a 15 week STZ-induced DN study we demonstrated that diabetic male mice receiving softened chow had reduced acute weight loss following STZ treatment ( p = 0.045) and additionally fewer mice were euthanized due to weight loss. By supplementing the diabetic mice with softened chow, no mice reached 20% weight loss whereas 37.5% of the mice without this supplement reached this humane endpoint ( p = 0.0027). Excretion of corticosterone metabolites in faeces was reduced in diabetic mice on softened chow ( p = 0.0007), suggesting lower levels of general stress. Finally, it was demonstrated that the water-softened chow supplement did not significantly affect the induction of key disease parameters, i.e. %HbA1C and albuminuria nor result in abnormal teeth wear. In conclusion, supplementation of softened food is refining the STZ-induced diabetic mouse model significantly by reducing stress, weight loss and the number of animals sacrificed due to humane endpoints, while maintaining the key phenotypes of diabetes and nephropathy.

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