Supramolecular ensembles modified by near-infrared dyes and their biological applications

2020 ◽  
Vol 8 (47) ◽  
pp. 10686-10699
Author(s):  
Tongxia Jin ◽  
Chusen Huang ◽  
Mengyu Cui ◽  
Yonghui Yang ◽  
Zhuo Wang ◽  
...  

This review presents recently developed supramolecular ensembles modified by near-infrared dyes. We discussed the construction of these near-infrared dyes-based ensembles and their biological application.

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 141
Author(s):  
Bruna Carvalho ◽  
Bruno Ceccato ◽  
Mariano Michelon ◽  
Sang Han ◽  
Lucimara de la Torre

Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein.


Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 14180-14187 ◽  
Author(s):  
Luyan Wu ◽  
Jie Hu ◽  
Qilin Zou ◽  
Yaling Lin ◽  
Decai Huang ◽  
...  

Y3(Al/Ga)5O12:Ce3+,Cr3+,Nd3+ nanocrystals with strong persistent luminescence in the NIR-II spectral region, which are highly desired for bioimaging, have been synthesized by a salt microemulsion method.


2020 ◽  
Vol 187 ◽  
pp. 111982 ◽  
Author(s):  
Yusif Issahak Gyasi ◽  
Yi-Peng Pang ◽  
Xin-Rui Li ◽  
Jing-Xue Gu ◽  
Xiao-Jing Cheng ◽  
...  

2015 ◽  
Vol 51 (19) ◽  
pp. 3989-3992 ◽  
Author(s):  
Dongdong Su ◽  
Chai Lean Teoh ◽  
Animesh Samanta ◽  
Nam-Young Kang ◽  
Sung-Jin Park ◽  
...  

ZWCC, a new zwitterionic NIR dye with high photostability and enhanced chemical stability, can be easily functionalized for biological applications.


2020 ◽  
Vol 4 (6) ◽  
pp. 1569-1585 ◽  
Author(s):  
Qiaoli Ren ◽  
Lu Ga ◽  
Zhili Lu ◽  
Jun Ai ◽  
Tie Wang

This review comprehensively summarizes potential biological application using aptamer-functionalized nanomaterials platform, focusing on explaining syntheses, properties, prospects and challenges.


2018 ◽  
Vol 16 (39) ◽  
pp. 7163-7169 ◽  
Author(s):  
Qing Wang ◽  
Kun Huang ◽  
Songtao Cai ◽  
Chang Liu ◽  
Xiaojie Jiao ◽  
...  

Seven rectilinearly π-extended NIR fluorescent rhodamines were synthesized via an intramolecular SNArH reaction under mild conditions without any transition metal catalyst or extra oxidant.


2020 ◽  
Vol 8 (45) ◽  
pp. 10257-10270
Author(s):  
Xiaoqian Ge ◽  
Ruoyan Wei ◽  
Lining Sun

We discuss designing efficient NIR-II-emitting lanthanide NPs and summarize their recent progress in bioimaging, therapy, and biosensing, as well as their limitations and future opportunities.


1996 ◽  
Vol 50 (2) ◽  
pp. 148-153 ◽  
Author(s):  
A. Beljebbar ◽  
G. D. Sockalingum ◽  
J. F. Angiboust ◽  
M. Manfait

An FT-Raman and FT-SERS microprobe with the spatial resolution on the micrometer scale has been developed. The main interfacing components are discussed and the whole setup is validated with the use of different SERS-active substrates: silver and gold colloids and gold island films. Micro-FT-SERS spectra of crocetin, mitoxantrone, and mitoxantrone/DNA complexes have been obtained, and the mass detection limits are found to be on the order of 5 × 102 molecules. Adsorption on the SERS-active substrates does not induce any detectable changes in the all-trans configuration of the crocetin. Adsorption of the mitoxantrone/DNA complex does not induce detectable perturbations of the molecular interactions within the complex. Moreover, interactions between the drug and DNA induces very similar effects in both the resonance Raman and FT-SERS spectra of the drugs. These effects were found to be consistent with the model of mitoxantrone/DNA intercalation proposed from nuclear magnetic resonance and resonance Raman data. The signal-to-noise ratios found indicate that submonolayer amounts of intracellularly localized drugs totaling less than 10−18 mole can be detected by means of the FT-SERS microprobe. Hence, both the extra-low mass detection limit of the technique and its sensitivity to interactions within the supramolecular complexes will in the future allow the drug to be followed within the living cell.


2021 ◽  
Vol 9 (10) ◽  
pp. 2457-2461
Author(s):  
Xin-Yue Zhang ◽  
Tian-Tian Liu ◽  
Jia-Hao Liang ◽  
Xiang-Ge Tian ◽  
Bao-Jing Zhang ◽  
...  

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-11) in the treatment against colorectal cancer and also has some relationship with the side effect of CPT-11 in clinical applications.


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