scholarly journals Aptamer-functionalized nanomaterials for biological applications

2020 ◽  
Vol 4 (6) ◽  
pp. 1569-1585 ◽  
Author(s):  
Qiaoli Ren ◽  
Lu Ga ◽  
Zhili Lu ◽  
Jun Ai ◽  
Tie Wang
Keyword(s):  
Biological Applications ◽  
Biological Application ◽  
Functionalized Nanomaterials

This review comprehensively summarizes potential biological application using aptamer-functionalized nanomaterials platform, focusing on explaining syntheses, properties, prospects and challenges.

scholarly journals Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 141
Author(s):  
Bruna Carvalho ◽  
Bruno Ceccato ◽  
Mariano Michelon ◽  
Sang Han ◽  
Lucimara de la Torre
Keyword(s):  
Lipid Nanoparticles ◽  
Future Trends ◽  
Biological Applications ◽  
Biological Application ◽  
Shell Nanoparticles ◽  
Cellular Environment ◽  
Wide Range ◽  
Core Shell Nanoparticles ◽  
New Strategies ◽  
Lipid Structures

Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein.

MICROBEAM ANALYSIS SYSTEM AT TOHOKU UNIVERSITY

2004 ◽  
Vol 14 (01n02) ◽  
pp. 1-7 ◽  
Author(s):  
S. MATSUYAMA ◽  
K. ISHII ◽  
H. YAMAZAKI ◽  
Y. BARBOTTEAU ◽  
TS. AMARTAIVAN ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Simultaneous Measurement ◽  
Beam Current ◽  
Biological Applications ◽  
Biological Application ◽  
Microbeam Analysis ◽  
Analysis System

A microbeam analysis system has been developed at Tohoku University for biological applications. Spatial resolution of less than 1 μm has been achieved with a beam current of ~40 pA. In microbeam analysis of biological specimens, simultaneous measurement of structural and elemental properties is very important. Our system is applicable to simultaneous in-air/vacuum PIXE, RBS and STIM analyses. Typical results of biological application are shown.

Supramolecular ensembles modified by near-infrared dyes and their biological applications

2020 ◽  
Vol 8 (47) ◽  
pp. 10686-10699
Author(s):  
Tongxia Jin ◽  
Chusen Huang ◽  
Mengyu Cui ◽  
Yonghui Yang ◽  
Zhuo Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Biological Applications ◽  
Biological Application ◽  
Supramolecular Ensembles

This review presents recently developed supramolecular ensembles modified by near-infrared dyes. We discussed the construction of these near-infrared dyes-based ensembles and their biological application.

scholarly journals Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

2020 ◽  
Vol 13 (6) ◽  
pp. 111
Author(s):  
Karol Biernacki ◽  
Mateusz Daśko ◽  
Olga Ciupak ◽  
Konrad Kubiński ◽  
Janusz Rachon ◽  
...  
Keyword(s):  
Biological Activities ◽  
Wide Spectrum ◽  
Heterocyclic Ring ◽  
The Novel ◽  
Biological Applications ◽  
Biological Application ◽  
Comprehensive Overview ◽  
Oxadiazole Derivatives ◽  
Novel Drug ◽  
Further Development

Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently accessible drugs containing 1,2,4-oxadiazole unit. It is worth noting that the interest in a 1,2,4-oxadiazoles’ biological application has been doubled in the last fifteen years. Herein, after a concise historical introduction, we present a comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years as well as brief remarks on prospects for further development.

scholarly journals Fluorescent Gold Nanoclusters: Synthesis and Recent Biological Application

2015 ◽  
Vol 2015 ◽  
pp. 1-23 ◽  
Author(s):  
Xiaochao Qu ◽  
Yichen Li ◽  
Lei Li ◽  
Yanran Wang ◽  
Jingning Liang ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Gold Nanoclusters ◽  
Synthetic Methods ◽  
Biological Applications ◽  
Biological Sensing ◽  
Biological Application ◽  
Controllable Synthesis ◽  
Size Dependent ◽  
Metal Atoms ◽  
Recent Advances

Fluorescent gold nanoclusters (AuNCs) have been extensively studied due to their unique construction and distinctive properties, which place them between single metal atoms and larger nanoparticles. The dimension of AuNCs is comparable to the Fermi wavelength of electrons, which lead to size-dependent fluorescence and other molecule-like properties. In this review, we summarize various synthesis strategies of fluorescent AuNCs and recent advances of biological applications such as biosensing, biolabeling, and bioimaging. The synthetic methods are considered as two routes: “Atoms to Clusters” and “Nanoparticles to Clusters.” The surface functionalization of AuNCs is described as the precondition for making future bioapplications possible, which can eventually influence their stability, biocompatibility, and other properties. And then we focus on the recent advances of AuNCs-based applications in biological sensing, biolabeling, and bioimaging and finally discuss the current challenges of AuNCs in controllable synthesis and biological application.

NUCLEIC ACID-FUNCTIONALIZED NANOMATERIALS

Nano LIFE ◽  
2013 ◽  
Vol 03 (01) ◽  
pp. 1340004 ◽  
Author(s):  
ISMAIL OCSOY ◽  
MUSERREF ARSLAN OCSOY ◽  
EMIR YASUN ◽  
WEIHONG TAN
Keyword(s):  
Nucleic Acid ◽  
Ethylene Glycol ◽  
Surface Functionalization ◽  
Wide Spectrum ◽  
Disease Diagnosis ◽  
Biocompatible Polymers ◽  
Biological Applications ◽  
Poly Ethylene Glycol ◽  
Functionalized Nanomaterials ◽  
Poly Ethylene

Nucleic acid (NA)-functionalized nanomaterials (NMs) have received considerable attention in recent years. The use of nucleic acid (DNA/RNA) for surface functionalization of NMs offers the ability to directly address desired targets and coat NMs with biocompatible polymers, such as poly [(ethylene)] glycol (PEG) and polyacrylamide (PA), enhancing the utility of these complexes in biomedicine. In particular, the target-specific recognition capacity of surface-functionalized NMs has opened up new avenues for disease diagnosis and therapy. This review focuses on the biological applications of a special type of nucleic acid, termed aptamer, conjugated with a variety of NMs for a wide spectrum of applications in nanobiomedicine.

A Prelude to Biogermylene Chemistry

2020 ◽  
Author(s):  
Pritam Mahawar, ◽  
Mishi Kaushal Wasson ◽  
Mahendra Kumar Sharma ◽  
Chandan Kumar Jha ◽  
Goutam Mukherjee ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Culture Medium ◽  
Human Cancer ◽  
Biological Applications ◽  
Biological Application ◽  
Antiproliferative Effects ◽  
Human Cancer Cells ◽  
Main Group Chemistry ◽  
Biological Studies ◽  
Anti Cancer

<p><b>Abstract:</b> The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (<b>3</b>) and its potential biological application (DPM = dipyrromethene ligand). Compound <b>3 </b>exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound <b>3 </b>on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.</p>

A Prelude to Biogermylene Chemistry

2020 ◽  
Author(s):  
Pritam Mahawar, ◽  
Mishi Kaushal Wasson ◽  
Mahendra Kumar Sharma ◽  
Chandan Kumar Jha ◽  
Goutam Mukherjee ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Culture Medium ◽  
Human Cancer ◽  
Biological Applications ◽  
Biological Application ◽  
Antiproliferative Effects ◽  
Human Cancer Cells ◽  
Main Group Chemistry ◽  
Biological Studies ◽  
Anti Cancer

<p><b>Abstract:</b> The biological applications of germylenes remain an unconceivable domain owing to their unstable nature. We report the isolation of air, water, and culture-medium stable germylene DPMGeOH (<b>3</b>) and its potential biological application (DPM = dipyrromethene ligand). Compound <b>3 </b>exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound <b>3 </b>on normal epithelial cells is minimal and is similar to that of the currently used anti-cancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main group chemistry.</p>

scholarly journals Deriving biological applications from domain specific process models

2007 ◽  
Vol 4 (1) ◽  
pp. 94-106 ◽  
Author(s):  
Stefan Jablonski ◽  
Matthias Faerber ◽  
Bernhard Volz ◽  
Stefanie Genthner
Keyword(s):  
Web Services ◽  
Process Modeling ◽  
Process Models ◽  
Biological Processes ◽  
Application Domain ◽  
Biological Applications ◽  
Biological Application ◽  
Specific Process ◽  
Domain Specific ◽  
Modeling Methodology

Abstract In this paper we present how the process modeling and execution tools iPM and iPE can be used to model and execute biological processes. The main focus of this paper is on the flexibility of iPM and iPE with respect to the customization to the biological application domain. We will demonstrate the flexibility of our modeling methodology by giving two examples: Modeling the invocation semantics of web services used in the biological application domain and the processing of streamed data.

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