A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds

2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Broad Spectrum ◽  
Electrolyte Balance ◽  
Infected Wounds ◽  
Multifunctional Properties

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.

scholarly journals Antimicrobial Activity of Biosynthesized Silver Nanoparticles Compared to Standard Antibiotics Used in ORL Infections

2019 ◽  
Vol 70 (7) ◽  
pp. 2571-2573
Author(s):  
Alina Andreea Tischer (Tucuina) ◽  
Delia Berceanu Vaduva ◽  
Nicolae Balica ◽  
Alina Heghes ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Antibiotic Resistance ◽  
Adverse Effects ◽  
Infectious Diseases ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
New Antibiotics ◽  
Recorded Data

In recent years, bacterial infections in hospitals have grown particularly due to the development of antibiotic resistance. Recent research targets the discovery of new antibiotics that exhibit broad spectrum of action without adverse effects or minimizing adverse effects. In this study, the activity of biosynthesized silver nanoparticles against three bacteria commonly found in infectious diseases in the ORL sphere was evaluated. The recorded data revealed an activity comparable to that of the standard antibiotics used in these types of infections, with the observation that the activity of the nanoparticles could also be observed in the particular cases of antibiotic resistance.

scholarly journals Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Yangkun Liu ◽  
JinChuan Fan ◽  
MingQi Lv ◽  
Kepeng She ◽  
Jiale Sun ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Aloe Vera ◽  
Antibacterial Properties ◽  
Composite Hydrogel ◽  
Wound Dressings ◽  
Full Thickness ◽  
Cutaneous Wounds

Abstract Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further improved. In this study, a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds. The composite hydrogel (Ag–AV–SF hydrogel) was prepared by introducing the silver nanoparticles (AgNPs) and aloe vera (AV) as the modifiers. In vitro study exhibited great antibacterial ability, biocompatibility and cell-proliferation and -migration-promoting capacities. It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment. The healing effect evaluation in vivo showed the healing-promoting ability of the Ag–AV–SF hydrogel was stronger than the single-modifiers groups, and the healing rate of it reached 97.02% on Day 21, higher than the commercial wound dressing, silver sulfadiazine (SS) cream on sale. Additionally, the histological and protein expression results showed that the Ag–AV–SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage, reconstructing the blood vessels networks and inhibiting the formation of scars. In summary, the Ag–AV–SF hydrogel developed in this study had good physical properties, overwhelming antibacterial properties, satisfactory biocompatibility and significantly promoting effect on cell proliferation, migration and wound healing. Overall, our results suggest that the Ag–AV–SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.

scholarly journals MODERN ANTICEPTIC HYDROGEL IN TREATMENT OF INFECTIOUS COMPLICATIONS OF WOUNDS IN SURGERY

2016 ◽  
Vol 175 (3) ◽  
pp. 26-31 ◽  
Author(s):  
G. E. Afinogenov ◽  
A. G. Afinogenova ◽  
D. Yu. Maday ◽  
K. M. Krylov ◽  
P. K. Krylov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Liquid Medium ◽  
Broad Spectrum ◽  
Infectious Complications ◽  
Infected Wound ◽  
Treatment And Prevention ◽  
Contaminated Wound ◽  
Series Of Experiments ◽  
Made In

Treatment and prevention of infectious complications remain the actual problems of surgery. Purulent complications very often arise in operative interventions with an application of various fixing devices. A study of the adhesive surgical antiseptic (ASA) «ARGAKOL» (Registration certificate № FS 012б2005/1878-05) was completed. The results of the preliminary antimicrobial activity of the developed composition showed that ASA «ARGAKOL» had a broad spectrum of antimicrobial action. There was used the method of twofold serial dilutions in a liquid medium and Cup-suspension. The study of the influence of the ASA «ARGAKOL» on the wound healing was made in the experiment on white outbred rats. There were carried out two series of experiments with 10 rats in each group: on the model of just contaminated wound (the first series) and on the model of infected wound with delayed application of the glue (after 3 days) after trauma (the second series).

A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

2020 ◽  
Vol 8 (24) ◽  
pp. 6930-6945
Author(s):  
Lingling Gao ◽  
Jingjie Chen ◽  
Wei Feng ◽  
Qing Song ◽  
Jingjing Huo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Broad Spectrum ◽  
Wound Dressing ◽  
Biological Activities ◽  
Hemorrhage Control ◽  
Injectable Hydrogel ◽  
Oxidized Dextran ◽  
Biodegradable Hydrogel

An injectable hydrogel wound dressing based on an oxidized dextran and ε-poly-l-lysine network has multiple biological activities.

scholarly journals Extracellular probiotic lipase capped silver nanoparticles as highly efficient broad spectrum antimicrobial agents

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31358-31365 ◽  
Author(s):  
Imran Khan ◽  
Nivetha Sivasankaran ◽  
Ravikiran Nagarjuna ◽  
Ramakrishnan Ganesan ◽  
Jayati Ray Dutta
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Ag Nps ◽  
Highly Efficient

A series of Ag NPs capped with different concentrations of probiotic lipase have been synthesized. The obtained Ag NPs exhibited efficient broad spectrum antimicrobial activity at concentrations much lower than the LC50values of zebrafish.

scholarly journals Synthesis of non-toxic, biocompatible, and colloidal stable silver nanoparticle using egg-white protein as capping and reducing agents for sustainable antibacterial application

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 23213-23229 ◽  
Author(s):  
Kalaiyarasan Thiyagarajan ◽  
Vijay K. Bharti ◽  
Shruti Tyagi ◽  
Pankaj K. Tyagi ◽  
Anami Ahuja ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Biomedical Applications ◽  
Egg White ◽  
Reducing Agents ◽  
Egg White Protein

For nearly a decade, silver nanoparticles (AgNPs) have been the most prevalent commercial nanomaterials products widely used in different biomedical applications due to their broad-spectrum antimicrobial activity.

scholarly journals Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Erika Adomavičiūtė ◽  
Sigitas Stanys ◽  
Modestas Žilius ◽  
Vaida Juškaitė ◽  
Alvydas Pavilonis ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Phenolic Compounds ◽  
Wound Dressing ◽  
Ethanolic Extract ◽  
Anticancer Activities ◽  
Dressing Materials ◽  
Fast Release

Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity onStaphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecalis,Escherichia coli,Pseudomonas aeruginosa,Proteus vulgaris,Bacillus subtilis,Bacillus cereus, andCandida albicansstrains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.

scholarly journals Injectable Methylcellulose and Hyaluronic Acid Hydrogel containing silver nanoparticles for their effective anti-microbial and wound healing activity in nursing care for burn injuries in children

2021 ◽  
Author(s):  
Jianye Jiang ◽  
Xiaojing Han ◽  
Huan Xu
Keyword(s):  
Electron Microscopy ◽  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Hyaluronic Acid ◽  
Nursing Care ◽  
Histological Study ◽  
Gelation Time ◽  
Burn Wound

Abstract Currently, the synthesis of silver nanoparticles (AgNPs) was utilized for various life-saving biomedical applications. Herein, we report the synthesis and characterization of methylcellulose and hyaluronic acid (MC-HA) hydrogels containing AgNPs dressing materials were investigated for their wound healing efficiency to treat surgical excision wounds and the findings were studied and discussed. The effect of the ratio of AgNPs and MC-HA hydrogels on the gelation time, in vitro degradation, and equilibrium swelling of MC-HA/AgNPs hydrogels was examined. The prepared MC-HA hydrogels containing AgNPs were studied using various characterization techniques such as UV–Visible spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The MC-HA/AgNPs showed excellent antimicrobial activity against S. aureus and E. coli, respectively. Additionally, the superior wound recovering potential of AgNPs with MC-HA hydrogels compared to conventional formulations was illustrated in vitro in animals utilizing visual observations and histological study. The MC-HA/AgNPs hydrogels showed excellent antimicrobial activity and burn wound healing. Therefore, these MC-HA hydrogels containing AgNPs have great potential medicinal applications in nursing care in children after surgery.

scholarly journals Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 866
Author(s):  
Carlos C. F. Pleeging ◽  
Tom Coenye ◽  
Dimitris Mossialos ◽  
Hilde de Rooster ◽  
Daniela Chrysostomou ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Wound Healing ◽  
Broad Spectrum ◽  
Biofilm Formation ◽  
Wound Care ◽  
Multidrug Resistant ◽  
Synergistic Activity ◽  
Medical Grade

Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for resistance. This study investigated the inhibitory and eradicative activity against multidrug-resistant Pseudomonas aeruginosa biofilms by different established MGH-based wound care formulations. Six different natural wound care products (Medihoney, Revamil, Mebo, Melladerm, L-Mesitran Ointment, and L-Mesitran Soft) were tested in vitro. Most of them contain MGH only, whereas some were supplemented. L-Mesitran Soft demonstrated the most potent antimicrobial activity (6.08-log inhibition and 3.18-log eradication). Other formulations ranged between 0.89-log and 4.80-log inhibition and 0.65-log and 1.66-log eradication. Therefore, the contribution of different ingredients of L-Mesitran Soft was investigated in more detail. The activity of the same batch of raw MGH (1.38-log inhibition and 2.35-log eradication), vitamins C and E (0.95-log inhibition and 0.94-log eradication), and all ingredients except MGH (1.69-log inhibition and 0.75-log eradication) clearly support a synergistic activity of components within the L-Mesitran Soft formulation. Several presented clinical cases illustrate its clinical antimicrobial efficacy against Pseudomonas aeruginosa biofilms. In conclusion, MGH is a potent treatment for Pseudomonas biofilms. L-Mesitran Soft has the strongest antimicrobial activity, which is likely due to the synergistic activity mediated by its supplements.

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