A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

2020 ◽  
Vol 8 (24) ◽  
pp. 6930-6945
Author(s):  
Lingling Gao ◽  
Jingjie Chen ◽  
Wei Feng ◽  
Qing Song ◽  
Jingjing Huo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Broad Spectrum ◽  
Wound Dressing ◽  
Biological Activities ◽  
Hemorrhage Control ◽  
Injectable Hydrogel ◽  
Oxidized Dextran ◽  
Biodegradable Hydrogel

An injectable hydrogel wound dressing based on an oxidized dextran and ε-poly-l-lysine network has multiple biological activities.

Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing

2019 ◽  
Vol 104 ◽  
pp. 109930 ◽  
Author(s):  
Xinchen Du ◽  
Yujie Liu ◽  
Xin Wang ◽  
Hongyu Yan ◽  
Lina Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Injectable Hydrogel ◽  
Oxidized Dextran ◽  
Modified Chitosan ◽  
Hydrophobically Modified

A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds

2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Broad Spectrum ◽  
Electrolyte Balance ◽  
Infected Wounds ◽  
Multifunctional Properties

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.

scholarly journals COMPARATIVE STUDY ON ANTIMICROBIAL ACTIVITY OF SEAWEEDS

2017 ◽  
Vol 10 (12) ◽  
pp. 384 ◽  
Author(s):  
Sasikala C ◽  
Geetha Ramani D
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Large Scale ◽  
Biological Activities ◽  
Maximum Activity ◽  
Significant Inhibition ◽  
Drug Formulation ◽  
Active Principle ◽  
Pharmaceutical Industries

Objective: Secondary metabolites from natural resources are a potential source of antimicrobial leads and drugs can exploited to combat antimicrobial resistance in microorganisms. Seaweeds are considered as a valuable source with a broad spectrum of biological activities. Hence, this study was undertaken to screen seaweeds from Mandapam coastal waters, East coast of India, for antimicrobial activity.Methods: Compounds were extracted using methanol from the seaweeds, namely, Halimeda gracilis, Caulerpa serrulata, Sargassum swartzii, Sargassum wightii, Jania rubens, Ulva lactuca, Ulva fasciata, Gracilaria corticata, Stoechospermum marginatum, Caulerpa scalpelliformis, Caulerpa taxifolia, Chaetomorpha crassa, Enteromorpha flexuosa, and Turbinaria ornate. The extracts were screened for their antimicrobial activity against selected bacterial and fungal pathogens.Results: In the present study, S. swartzii, J. rubens, and S. marginatum showed broad spectrum of antibacterial activity against all the test bacterial pathogens. Among these, the maximum activity was exhibited by S. swartzii against Enterococcus faecalis (27.00 ± 0.88) and Streptococcus pyogenes (23.00 ± 0.84), followed by J. rubens against E. faecalis (26.00 ± 0.56) and S. pyogenes (22.00 ± 0.75), and S. marginatum exhibited significant inhibition against Staphylococcus aureus (15.00 ± 0.22) and S. pyogenes (18.00 ± 1.16).Conclusion: These seaweeds with significant antibacterial activity will subjected to phytochemical screening to find out the potential active principle responsible for antimicrobial activity. It is followed by purification and characterization of the compounds for possible application in drug formulation, can take this to large-scale application in pharmaceutical industries.

scholarly journals MODERN ANTICEPTIC HYDROGEL IN TREATMENT OF INFECTIOUS COMPLICATIONS OF WOUNDS IN SURGERY

2016 ◽  
Vol 175 (3) ◽  
pp. 26-31 ◽  
Author(s):  
G. E. Afinogenov ◽  
A. G. Afinogenova ◽  
D. Yu. Maday ◽  
K. M. Krylov ◽  
P. K. Krylov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Liquid Medium ◽  
Broad Spectrum ◽  
Infectious Complications ◽  
Infected Wound ◽  
Treatment And Prevention ◽  
Contaminated Wound ◽  
Series Of Experiments ◽  
Made In

Treatment and prevention of infectious complications remain the actual problems of surgery. Purulent complications very often arise in operative interventions with an application of various fixing devices. A study of the adhesive surgical antiseptic (ASA) «ARGAKOL» (Registration certificate № FS 012б2005/1878-05) was completed. The results of the preliminary antimicrobial activity of the developed composition showed that ASA «ARGAKOL» had a broad spectrum of antimicrobial action. There was used the method of twofold serial dilutions in a liquid medium and Cup-suspension. The study of the influence of the ASA «ARGAKOL» on the wound healing was made in the experiment on white outbred rats. There were carried out two series of experiments with 10 rats in each group: on the model of just contaminated wound (the first series) and on the model of infected wound with delayed application of the glue (after 3 days) after trauma (the second series).

scholarly journals Nanomaterials in Wound Healing and Infection Control

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 473
Author(s):  
Ali Pormohammad ◽  
Nadia K. Monych ◽  
Sougata Ghosh ◽  
Diana L. Turner ◽  
Raymond J. Turner
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antibiotic Resistance ◽  
Infection Control ◽  
Persistent Infection ◽  
Wound Dressing ◽  
Healing Process ◽  
Wide Range ◽  
Different Types ◽  
Improve Wound Healing

Wounds continue to be a serious medical concern due to their increasing incidence from injuries, surgery, burns and chronic diseases such as diabetes. Delays in the healing process are influenced by infectious microbes, especially when they are in the biofilm form, which leads to a persistent infection. Biofilms are well known for their increased antibiotic resistance. Therefore, the development of novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm and wound healing properties are required. Nanomaterials (NM) have unique properties due to their size and very large surface area that leads to a wide range of applications. Several NMs have antimicrobial activity combined with wound regeneration features thus give them promising applicability to a variety of wound types. The idea of NM-based antibiotics has been around for a decade at least and there are many recent reviews of the use of nanomaterials as antimicrobials. However, far less attention has been given to exploring if these NMs actually improve wound healing outcomes. In this review, we present an overview of different types of nanomaterials explored specifically for wound healing properties combined with infection control.

scholarly journals Computer-aided Identification of Synergetic Wound Healing Mechanisms Exhibited by Compounds in the Bio Synthesized Wound Dressing Material

2021 ◽  
Vol 10 (4) ◽  
pp. 2831-2842
Keyword(s):  
Wound Healing ◽  
Bioactive Compounds ◽  
Wound Dressing ◽  
Biological Activities ◽  
Mangifera Indica ◽  
Beta Carotene ◽  
Fish Scale ◽  
Spider Web ◽  
Healing Wound ◽  
Pass Online

A wound dressing material synthesized from the bio-composites of chicken fibrin, fish scale collagen impregnated with the spider web, and the ethanolic leaves extract of Mangifera indica (L.). The synthesized biomaterial was analyzed by GC-MS analysis. The present study involves identifying bioactive compounds that may heal wounds from the biosynthetic wound dressing material and the biological activities determined with the help of PASS software online prediction. PASS online software is used to explore the mechanism involved in healing wound compounds. Ten bioactive compounds identified as wound healing agents 2-methyl 4-Heptanol, 3-methoxy Hexane, Stigmasterol, Z-3,17-Octadecadien-1-ol acetate, 3-Chloro-5 Cholestene, 9,12,15 Octadecatrienoic acid 2,3 –Bis(acetyloxy) propyl ester(Z, Z, Z), Trans-Z-.alpha.-bisabolene epoxide, Beta carotene, Nopyl Acetate, 9,12 Octadecadienoic acid (Z, Z)phenylmethyl ester, and their bioactivities analyzed. Analyzed bio compounds found to exhibit wound healing mechanisms.

scholarly journals Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation

2007 ◽  
Vol 4 (1) ◽  
pp. 60-66 ◽  
Author(s):  
T. A. Naik ◽  
K. H. Chikhalia
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Insecticidal Activity ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Pyrimidine Derivatives ◽  
Pharmacological Evaluation ◽  
Antitumor Properties ◽  
Morpholine Derivatives ◽  
Anticonvulsant Activities

1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of antimicrobial activity and exhibit anthelmintic, bactericidal and insecticidal activity. Pyrimidine derivatives are also reported to possess antibacterial, antimicrobial, antifungal, anticancer and anticonvulsant activities. Encouraged by this observations we decided to synthesised novel pyrimidine derivatives.

scholarly journals Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Erika Adomavičiūtė ◽  
Sigitas Stanys ◽  
Modestas Žilius ◽  
Vaida Juškaitė ◽  
Alvydas Pavilonis ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Phenolic Compounds ◽  
Wound Dressing ◽  
Ethanolic Extract ◽  
Anticancer Activities ◽  
Dressing Materials ◽  
Fast Release

Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity onStaphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecalis,Escherichia coli,Pseudomonas aeruginosa,Proteus vulgaris,Bacillus subtilis,Bacillus cereus, andCandida albicansstrains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.

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