Strategies and challenges to improve the performance of tumor-associated active targeting

2020 ◽  
Vol 8 (18) ◽  
pp. 3959-3971 ◽  
Author(s):  
Yahui Zhang ◽  
Jing Cao ◽  
Zhi Yuan
Keyword(s):  
Active Targeting ◽  
Irreversible Ligand

Schematic of irreversible ligand shielding strategy and reversible ligand shielding strategy.

Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy

2017 ◽  
Vol 23 (3) ◽  
pp. 454-466 ◽  
Author(s):  
Daniele R. Nogueira-Librelotto ◽  
Cristiane F. Codevilla ◽  
Ammad Farooqi ◽  
Clarice M. B. Rolim
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Therapeutic Benefit ◽  
Active Targeting ◽  
Future Research ◽  
Passive Targeting ◽  
The Right ◽  
Review Current ◽  
Target Effects

A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

scholarly journals Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

2021 ◽  
Vol 6 (12) ◽  
pp. 4402-4414
Author(s):  
Yueyue Fan ◽  
Yuexin Cui ◽  
Wenyan Hao ◽  
Mengyu Chen ◽  
Qianqian Liu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Active Targeting ◽  
Carrier Free

scholarly journals Comparison Direct Synthesis of Hyaluronic Acid-Based Carbon Nanodots as Dual Active Targeting and Imaging of HeLa Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Yu-Yu Aung ◽  
Aswandi Wibrianto ◽  
Jefry S. Sianturi ◽  
Desita K. Ulfa ◽  
Satya. C. W. Sakti ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Direct Synthesis ◽  
Active Targeting ◽  
Carbon Nanodots

Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density

Biomaterials ◽  
2014 ◽  
Vol 35 (27) ◽  
pp. 8015-8027 ◽  
Author(s):  
Zhaomin Tang ◽  
Dan Li ◽  
Huili Sun ◽  
Xing Guo ◽  
Yuping Chen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Active Targeting ◽  
Ligand Density

Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 92073-92091 ◽  
Author(s):  
Yujuan Chen ◽  
Hui Zhang ◽  
Xiaoqing Cai ◽  
Jianbo Ji ◽  
Shuwang He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Functional Groups ◽  
Anticancer Drugs ◽  
Outer Surface ◽  
Active Targeting ◽  
Stimuli Responsive ◽  
Target Delivery

By modifying the outer surface of MSNs with various functional groups or/and using a combination with other nanomaterials, stimuli-responsive and active targeting nanosystems can be designed for stimuli-responsive target delivery of anticancer drugs.

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