scholarly journals Comparison Direct Synthesis of Hyaluronic Acid-Based Carbon Nanodots as Dual Active Targeting and Imaging of HeLa Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Yu-Yu Aung ◽  
Aswandi Wibrianto ◽  
Jefry S. Sianturi ◽  
Desita K. Ulfa ◽  
Satya. C. W. Sakti ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Direct Synthesis ◽  
Active Targeting ◽  
Carbon Nanodots

scholarly journals Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Silvia Arpicco ◽  
Giuseppe De Rosa ◽  
Elias Fattal
Keyword(s):  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Delivery Systems ◽  
Living Systems ◽  
Active Targeting ◽  
Acid Receptor ◽  
Naturally Occurring ◽  
Low Levels

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that exists in living systems, and it is a major component of the extracellular matrix. The hyaluronic acid receptor CD44 is found at low levels on the surface of epithelial, haematopoietic, and neuronal cells and is overexpressed in many cancer cells particularly in tumour initiating cells. HA has been therefore used as ligand attached to HA-lipid-based nanovectors for the active targeting of small or large active molecules for the treatment of cancer. This paper describes the different approaches employed for the preparation, characterization, and evaluation of these potent delivery systems.

An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cells

2020 ◽  
Vol 107 ◽  
pp. 65-77 ◽  
Author(s):  
Akshay A. Narkhede ◽  
James H. Crenshaw ◽  
David K. Crossman ◽  
Lalita A. Shevde ◽  
Shreyas S. Rao
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Hyaluronic Acid Hydrogel

scholarly journals ID: 1038 Hydrothermal synthesis of carbon nanodots from millets for cancer cells imaging

2017 ◽  
Vol 4 (S) ◽  
pp. 116
Author(s):  
Quang Ngo Khoa ◽  
Tran Thi Xuan Thuy ◽  
Che Thi Cam Ha
Keyword(s):  
Hydrothermal Synthesis ◽  
Cancer Cells ◽  
Biomedical Application ◽  
Average Diameter ◽  
Optical Measurements ◽  
Carbon Nanodots ◽  
Excitation Wavelength ◽  
Economical Method ◽  
Potential Applications ◽  
Multicolor Fluorescence

We presented a green, simple and economical method to synthesize carbon nanodots (C-dots) from millets using hydrothermal synthesis route. The obtained C-dots have average diameter ranging from 6 to 8 nm. Optical measurements showed the formation of hydroxyl, carbonyl/carboxyl, amino functional groups on the particle surfaces, resulting in their high hydrophilicity and bioconjugation. After treatment with C-dots, human cervical and lung cancer cells became bright and exhibited multicolor fluorescence under different excitation wavelength. The achievement demonstrated potential applications of fluorescent C-dots in the field of biomedical application, especially in diagnostic disease techniques.

scholarly journals Anti-ROR1 functionalised PLGA nanoparticles modulate metastatic and EMT biomarkers via cellular uptake of curcumin and ICA in colon cancer cells SW480

2020 ◽  
Author(s):  
Shamim Sufi ◽  
Muddasarul Hoda ◽  
Sankar Pajaniradje ◽  
Victor Mukherjee ◽  
Sultana Parveen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Isothermal Calorimetry ◽  
Cell Surface Receptor ◽  
In Vivo Studies ◽  
Active Targeting ◽  
Colon Cancer Cells ◽  
Mesenchymal Transition ◽  
Surface Functionalisation

The challenge of next-generation nanoparticles (NPs) includes limited cellular uptake and loss by phagocytosis. General surface modification of NPs potentially enhances evasion from phagocytosis. However, active targeting and enhanced cellular uptake of nanoparticles are possible by surface functionalisation with molecules that have selective affinity for cancer cells. ROR1 is a cell surface receptor that is over-expressed in cancer cells. Hence, its conjugate antibody could be a potential surface functionalisation molecule. In the current study, anti-ROR1 antibody has been covalently attached to nanoparticles’ surface, thereby imparting its active targeting potential. Physicochemical and in vitro characterisations of the antibody-conjugated nanoparticles were performed. Surface functionalisation of nanoparticles was confirmed by scanning electron microscopy, isothermal calorimetry, and elemental analysis. Additionally, biomarkers of metastasis and epithelial-mesenchymal transition (EMT) were studied. Anti-ROR1 mAb tagged nanoparticles further confirmed therapeutic efficacy against colon cancer cells, SW480, thus, opening scope for further in vivo studies.

pH- and GSH-Sensitive Hyaluronic Acid-MP Conjugate Micelles for Intracellular Delivery of Doxorubicin to Colon Cancer Cells and Cancer Stem Cells

2018 ◽  
Vol 19 (9) ◽  
pp. 3725-3737 ◽  
Author(s):  
Tilahun Ayane Debele ◽  
Lu-Yi Yu ◽  
Cheng-Sheng Yang ◽  
Yao-An Shen ◽  
Chun-Liang Lo
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Intracellular Delivery ◽  
Colon Cancer Cells
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