Multifunctional mesoporous silica nanocarriers for stimuli-responsive target delivery of anticancer drugs

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 92073-92091 ◽  
Author(s):  
Yujuan Chen ◽  
Hui Zhang ◽  
Xiaoqing Cai ◽  
Jianbo Ji ◽  
Shuwang He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Functional Groups ◽  
Anticancer Drugs ◽  
Outer Surface ◽  
Active Targeting ◽  
Stimuli Responsive ◽  
Target Delivery

By modifying the outer surface of MSNs with various functional groups or/and using a combination with other nanomaterials, stimuli-responsive and active targeting nanosystems can be designed for stimuli-responsive target delivery of anticancer drugs.

scholarly journals Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 527 ◽  
Author(s):  
Sugata Barui ◽  
Valentina Cauda
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Therapeutics ◽  
High Loading ◽  
Active Targeting ◽  
Stimuli Responsive

The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

Synthesis of Smart Mesoporous Materials

2003 ◽  
Vol 775 ◽  
Author(s):  
G.V.Rama Rao ◽  
Qiang Fu ◽  
Linnea K. Ista ◽  
Huifang Xu ◽  
S. Balamurugan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Mesoporous Materials ◽  
Fluorescent Dyes ◽  
Thermo Gravimetric Analysis ◽  
Molecular Transport ◽  
Solute Diffusion ◽  
Gravimetric Analysis ◽  
Stimuli Responsive ◽  
Porous Network ◽  
Hybrid Mesoporous Materials

AbstractThis study details development of hybrid mesoporous materials in which molecular transport through mesopores can be precisely controlled and reversibly modulated. Mesoporous silica materials formed by surfactant templating were modified by surface initiated atom transfer radical polymerization of poly(N-isopropyl acrylamide) (PNIPAAm) a stimuli responsive polymer (SRP) within the porous network. Thermo gravimetric analysis and FTIR spectroscopy were used to confirm the presence of PNIPAAm on the silica surface. Nitrogen porosimetry, transmission electron microscopy and X-ray diffraction analyses confirmed that polymerization occurred uniformly within the porous network. Uptake and release of fluorescent dyes from the particles was monitored by spectrofluorimetry and scanning laser confocal microscopy. Results suggest that the presence of PNIPAAm, a SRP, in the porous network can be used to modulate the transport of aqueous solutes. At low temperature, (e.g., room temperature) the PNIPAAm is hydrated and extended and inhibits transport of analytes; at higher temperatures (e.g., 50°C) it is hydrophobic and is collapsed within the pore network, thus allowing solute diffusion into or out of the mesoporous silica. The transition form hydrophilic to hydrophobic state on polymer grafted mesoporous membranes was determined by contact angle measurements. This work has implications for the development of materials for the selective control of transport of molecular solutes in a variety of applications.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

Stimuli-responsive organic-inorganic mesoporous silica hybrids: A comprehensive review on synthesis and recent advances

2021 ◽  
Vol 270 ◽  
pp. 115232
Author(s):  
Jerome Peter ◽  
Riyasudheen Nechikkattu ◽  
Anandhu Mohan ◽  
Anju Maria Thomas ◽  
Chang-Sik Ha
Keyword(s):  
Mesoporous Silica ◽  
Stimuli Responsive ◽  
Comprehensive Review ◽  
Recent Advances ◽  
Silica Hybrids

RhNPs supported on N-functionalized mesoporous silica: effect on catalyst stabilization and catalytic activity

2021 ◽  
Author(s):  
Israel T. Pulido-Díaz ◽  
Alejandro Serrano-Maldonado ◽  
Carlos César López-Suárez ◽  
Pedro A. Méndez-Ocampo ◽  
Benjamín Portales-Martínez ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Mesoporous Silica ◽  
Functional Groups ◽  
Hydrogenation Catalysts ◽  
Functionalized Mesoporous Silica ◽  
Catalyst Stabilization ◽  
Shape And Size

RhNPs supported on mesoporous silica functionalized with nicotinamide groups provided active hydrogenation catalysts for several functional groups, wherein the shape and size of the RhNPs are maintained after catalysis.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

Engineering surface functional groups on mesoporous silica: towards a humidity-resistant hydrophobic adsorbent

2018 ◽  
Vol 6 (28) ◽  
pp. 13769-13777 ◽  
Author(s):  
Shuai Liu ◽  
Yue Peng ◽  
Jianjun Chen ◽  
Wenbo Shi ◽  
Tao Yan ◽  
...  
Keyword(s):  
Surface Modification ◽  
Thermal Treatment ◽  
Mesoporous Silica ◽  
Functional Groups ◽  
Surface Functional Groups ◽  
Adsorption Selectivity

Manipulating surface modification through a selective thermal treatment, an adsorbent with high hydrophobicity and adsorption selectivity for toluene was fabricated.

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