scholarly journals Spatiotemporally controlled O2 and singlet oxygen self-sufficient nanophotosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy

2020 ◽  
Vol 11 (33) ◽  
pp. 8817-8827 ◽  
Author(s):  
Suisui He ◽  
Siyu Lu ◽  
Sha Liu ◽  
Tianrong Li ◽  
Jieling Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tumor Therapy ◽  
High Yield ◽  
Drug Synthesis ◽  
Hypoxic Tumor

A porous photosensitizer displaying catalase-like activity and drug synthesis ability was synthesized for the synergistic chemo-photodynamic therapy, opening new promising ways for carrying out the precise cooperative treatment of hypoxic tumors.

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

In vivo monitoring of singlet oxygen using delayed chemiluminescence during photodynamic therapy

2007 ◽  
Vol 12 (1) ◽  
pp. 014002 ◽  
Author(s):  
Yanchun Wei ◽  
Jing Zhou ◽  
Da Xing ◽  
Qun Chen
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
In Vivo Monitoring

Photoacoustic Imaging Application in Tumor Diagnosis and Treatment Monitoring

2007 ◽  
Vol 364-366 ◽  
pp. 1100-1104 ◽  
Author(s):  
Liang Zhong Xiang ◽  
Fei Fan Zhou
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Single Pulse ◽  
Treatment Monitoring ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Imaging Application ◽  
Early Tumor

Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic system, a single pulse laser beam was used as the light source for both cancer treatment and for concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system was used to detect early tumor on the rat back, and the vascular structure around the tumor could be imaged clearly with optimal contrast. This system was also used to monitoring damage of the vascular structures before, during and after photodynamic therapy of tumor. This work demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy and other phototherapies using vascular changes during treatment. Prospective application of photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to guide nanoshell-based thermal tumor therapy.

A Novel Theranostic Nanoprobe for In Vivo Singlet Oxygen Detection and Real‐Time Dose–Effect Relationship Monitoring in Photodynamic Therapy

Small ◽  
2019 ◽  
Vol 15 (39) ◽  
pp. 1902185 ◽  
Author(s):  
Han Wang ◽  
Zhaohui Wang ◽  
Yongkuan Li ◽  
Tian Xu ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Real Time ◽  
Dose Effect ◽  
Effect Relationship ◽  
Oxygen Detection ◽  
Time Dose

Riboflavin-Based Carbon Dots with High Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Juan Yue ◽  
Li Li ◽  
Chenyu Jiang ◽  
Qian Mei ◽  
Wen-Fei Dong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Effective Treatment ◽  
Carbon Dots ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photodynamic therapy, as an effective treatment for superficial tumors, has attracted more and more attention. The development of safe, biocompatible and in vivo photosensitive materials is helpful to promote photodynamic...

scholarly journals Errata: Pulsed diode laser-based singlet oxygen monitor for photodynamic therapy: in vivo studies of tumor-laden rats

2009 ◽  
Vol 14 (1) ◽  
pp. 019801
Author(s):  
Seonkyung Lee ◽  
Danthu H. Vu ◽  
Michael F. Hinds ◽  
Steven J. Davis ◽  
Alvin Liang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Diode Laser ◽  
In Vivo Studies ◽  
Oxygen Monitor

scholarly journals A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chao Liang ◽  
Jiaen Xie ◽  
Shuangling Luo ◽  
Can Huang ◽  
Qianling Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Simple Structure ◽  
Basic Structure ◽  
High Yield ◽  
Tissue Penetration ◽  
Facile Synthesis ◽  
Sonodynamic Therapy

AbstractAs a basic structure of most polypyridinal metal complexes, [Ru(bpy)3]2+, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)3]2+ has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)3]2+ is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)3]2+ can produce singlet oxygen (1O2) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)3]2+ enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer.

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