A Novel Theranostic Nanoprobe for In Vivo Singlet Oxygen Detection and Real‐Time Dose–Effect Relationship Monitoring in Photodynamic Therapy

Small ◽  
2019 ◽  
Vol 15 (39) ◽  
pp. 1902185 ◽  
Author(s):  
Han Wang ◽  
Zhaohui Wang ◽  
Yongkuan Li ◽  
Tian Xu ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Real Time ◽  
Dose Effect ◽  
Effect Relationship ◽  
Oxygen Detection ◽  
Time Dose

scholarly journals SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION

2013 ◽  
Vol 06 (01) ◽  
pp. 1330002 ◽  
Author(s):  
BUHONG LI ◽  
HUIYUN LIN ◽  
DEFU CHEN ◽  
BRIAN C. WILSON ◽  
YING GU
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Direct Methods ◽  
Photochemical Reactions ◽  
Oxygen Species ◽  
Future Trends ◽  
Oxygen Detection

Singlet oxygen (1O2) is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in different biological systems and in particular, in photodynamic therapy (PDT). However, the quantification of 1O2 generation during in vitro and in vivo photosensitization is still technically challenging. To address this problem, indirect and direct methods for 1O2 detection have been intensively studied. This review presents the available methods currently in use or under development for detecting and quantifying 1O2 generation during photosensitization. The advantages and limitations of each method will be presented. Moreover, the future trends in developing PDT- 1O2 dosimetry will be briefly discussed.

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

Antimicrobial effect of photodynamic therapy in carious lesions in vivo, using culture and real-time PCR methods

2015 ◽  
Vol 12 (3) ◽  
pp. 401-407 ◽  
Author(s):  
Patricia Valente Araújo ◽  
Jeane de Fátima Correia-Silva ◽  
Ricardo Santiago Gomez ◽  
Maria de Lourdes de Andrade Massara ◽  
Maria Esperanza Cortes ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Pcr ◽  
Antimicrobial Effect ◽  
Carious Lesions

In vivo monitoring of singlet oxygen using delayed chemiluminescence during photodynamic therapy

2007 ◽  
Vol 12 (1) ◽  
pp. 014002 ◽  
Author(s):  
Yanchun Wei ◽  
Jing Zhou ◽  
Da Xing ◽  
Qun Chen
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
In Vivo Monitoring

scholarly journals Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy

Biomaterials ◽  
2019 ◽  
Vol 201 ◽  
pp. 33-41 ◽  
Author(s):  
Yansong Feng ◽  
Yanni Wu ◽  
Jing Zuo ◽  
Langping Tu ◽  
Ivo Que ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Real Time Imaging

Riboflavin-Based Carbon Dots with High Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Juan Yue ◽  
Li Li ◽  
Chenyu Jiang ◽  
Qian Mei ◽  
Wen-Fei Dong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Effective Treatment ◽  
Carbon Dots ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photodynamic therapy, as an effective treatment for superficial tumors, has attracted more and more attention. The development of safe, biocompatible and in vivo photosensitive materials is helpful to promote photodynamic...

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