Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial basal cell carcinomas

2011 ◽  
Vol 16 (4) ◽  
pp. 048002 ◽  
Author(s):  
Ronan M. Valentine ◽  
C. Tom A. Brown ◽  
Harry Moseley ◽  
Sally Ibbotson ◽  
Kenny Wood
Keyword(s):  
Monte Carlo ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Basal Cell ◽  
Protoporphyrin Ix ◽  
Oxygen Production ◽  
Monte Carlo Modeling ◽  
Basal Cell Carcinomas

scholarly journals Parallel fluorescence and phosphorescence monitoring of singlet oxygen photosensitization in rats

2015 ◽  
Vol 08 (06) ◽  
pp. 1550037 ◽  
Author(s):  
Roman Dědic ◽  
Adam Stíbal ◽  
Vojtěch Vyklický ◽  
Miloslav Franěk ◽  
Antonín Svoboda ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Normal Skin ◽  
Protoporphyrin Ix ◽  
Laboratory Animals ◽  
Control Group ◽  
Fluorescence Signal ◽  
Oxygen Production ◽  
Dominant Feature ◽  
Set Up

The time- and spectral-resolved set-up for measurements of weak infrared luminescence of photosensitizers (PSs) and singlet oxygen using optical lightguides was used on skin of laboratory animals in vivo. Wistar rats with abdominal incisions treated by methylis aminolevulinitis (MAL) were used as a model. A control group of animals with abdominal incisions was also tested. Spectrally resolved fluorescence of the PS was acquired during the treatment from the same spot. The intensity and spectral profile of the fluorescence signal from the skin can be used to guide the detection setup to the investigated spots in the lesion. The rate of bleaching of Protoporphyrin IX band and appearance of a band of its photoproducts during the treatment can be characterized by the exposition ED, under which the latter becomes dominant feature in fluorescence spectrum. ED value differs statistically significantly between the normal skin and the lesion treated by MAL. No direct proportionality was found between the fluorescence signal and singlet oxygen production. Nevertheless, the strong fluorescence signal is necessary but not a sufficient condition for higher singlet oxygen production in vivo. ED value correlates rather well with production of singlet oxygen, but differently in lesion and normal skin. Lifetimes of singlet oxygen differ between spots outside and in the lesion. PS triplet state lifetimes exhibit weak difference between spots treated and untreated by MAL.

Efficient functionalization of gold nanoparticles using cysteine conjugated protoporphyrin IX for singlet oxygen production in vitro

RSC Advances ◽  
2015 ◽  
Vol 5 (127) ◽  
pp. 104621-104628 ◽  
Author(s):  
Mohsen Ashjari ◽  
Soheila Dehfuly ◽  
Daryoush Fatehi ◽  
Ronak Shabani ◽  
Morteza Koruji
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Protoporphyrin Ix ◽  
Therapeutic Agents ◽  
Signal Enhancement ◽  
Oxygen Production ◽  
Effective Signal

Gold nanoparticles with suitable properties are supreme therapeutic agents and provide effective signal enhancement in photodynamic therapy (PDT).

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

scholarly journals Early apoptosis plays an important role in the healing mechanism of cutaneous basal cell carcinomas after photodynamic therapy

2003 ◽  
Vol 149 (1) ◽  
pp. 205-206 ◽  
Author(s):  
F. Prignano ◽  
B. Bianchi ◽  
L. Domenici ◽  
R. Rossi ◽  
P. Romagnoli ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basal Cell ◽  
Basal Cell Carcinomas ◽  
Early Apoptosis
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