Combined experimental and theoretical insight into the drug delivery of nanoporous metal–organic frameworks

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85606-85612 ◽  
Author(s):  
Jiaping Wang ◽  
Juncheng Jin ◽  
Fumei Li ◽  
Baohong Li ◽  
Jianqiang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Level ◽  
Load Capacity ◽  
Metal Organic Frameworks ◽  
Void Space ◽  
Drug Load ◽  
Nanoporous Metal ◽  
Metal Organic ◽  
Theoretical Insight ◽  
Insight Into

The comparison between calculated drug load values and some molecular level properties indicates the existence of a relationship between the void space of material and drug load capacity.

Quantum Mechanical Interpretation of the Ultra-Low Energy Methyl-Rotation Dynamics in Porous Metal-Organic Frameworks Probed by Low-Frequency Vibrational Spectroscopy and ab initio Simulations

2018 ◽  
Author(s):  
Qi Li ◽  
Adam J. Zaczek ◽  
Timothy M. Korter ◽  
J. Axel Zeitler ◽  
Michael T. Ruggiero
Keyword(s):  
Ab Initio ◽  
Metal Organic Frameworks ◽  
Low Frequency ◽  
Rotor Dynamics ◽  
Quantum Mechanical ◽  
Valuable Insight ◽  
Void Space ◽  
Ab Initio Simulations ◽  
Metal Organic ◽  
Insight Into

<div>Understanding the nature of the interatomic interactions present within the pores of metal-organic frameworks</div><div>is critical in order to design and utilize advanced materials</div><div>with desirable applications. In ZIF-8 and its cobalt analogue</div><div>ZIF-67, the imidazolate methyl-groups, which point directly</div><div>into the void space, have been shown to freely rotate - even</div><div>down to cryogenic temperatures. Using a combination of ex-</div><div>perimental terahertz time-domain spectroscopy, low-frequency</div><div>Raman spectroscopy, and state-of-the-art ab initio simulations,</div><div>the methyl-rotor dynamics in ZIF-8 and ZIF-67 are fully charac-</div><div>terized within the context of a quantum-mechanical hindered-</div><div>rotor model. The results lend insight into the fundamental</div><div>origins of the experimentally observed methyl-rotor dynamics,</div><div>and provide valuable insight into the nature of the weak inter-</div><div>actions present within this important class of materials.</div>

Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

2011 ◽  
Vol 23 (47) ◽  
pp. 5629-5632 ◽  
Author(s):  
Chun-Yi Sun ◽  
Chao Qin ◽  
Chun-Gang Wang ◽  
Zhong-Min Su ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Nanoporous Metal ◽  
Metal Organic

Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications

2017 ◽  
Vol 22 (4) ◽  
pp. 625-637 ◽  
Author(s):  
Sarwar Beg ◽  
Mahfoozur Rahman ◽  
Atul Jain ◽  
Sumant Saini ◽  
Patrick Midoux ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Hybrid Polymer ◽  
Metal Composites ◽  
Nanoporous Metal ◽  
Polymer Metal ◽  
Metal Organic

Encapsulation of pharmaceutical ingredient linker in metal–organic framework: combined experimental and theoretical insight into the drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (53) ◽  
pp. 47959-47965 ◽  
Author(s):  
Fumei Li ◽  
Baohong Li ◽  
Chunfeng Wang ◽  
Yongping Zeng ◽  
Jianqiang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Adsorption ◽  
Matrix Interactions ◽  
Metal Organic ◽  
Theoretical Insight ◽  
Insight Into ◽  
Organic Framework

This work studied the effect of this relationship on the drug adsorption and delivery of pharmacological molecules. The GCMC has been performed in order to support the drug–matrix interactions in the pore of the material.

scholarly journals Recent advances in nanosized metal organic frameworks for drug delivery and tumor therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 3241-3263
Author(s):  
Junlei Yang ◽  
Hui Wang ◽  
Jinyao Liu ◽  
Mengkui Ding ◽  
Xianjin Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Recent Advances ◽  
Metal Organic ◽  
Insight Into

This review provides an overview of the recent advances in nano-MOFs for drug delivery and tumor therapy and some insight into present challenges and prospects.

scholarly journals An experimental and computational study of CO2adsorption in the sodalite-type M-BTT (M = Cr, Mn, Fe, Cu) metal–organic frameworks featuring open metal sites

2018 ◽  
Vol 9 (20) ◽  
pp. 4579-4588 ◽  
Author(s):  
Mehrdad Asgari ◽  
Sudi Jawahery ◽  
Eric D. Bloch ◽  
Matthew R. Hudson ◽  
Roxana Flacau ◽  
...  
Keyword(s):  
Molecular Level ◽  
Computational Study ◽  
Metal Organic Frameworks ◽  
Adsorption Properties ◽  
Open Metal Sites ◽  
Metal Organic ◽  
Insight Into

The work provides molecular level insight into the CO2adsorption properties of an isostructural series of MOFs, known as M-BTT.

Quantum Mechanical Interpretation of the Ultra-Low Energy Methyl-Rotation Dynamics in Porous Metal-Organic Frameworks Probed by Low-Frequency Vibrational Spectroscopy and ab initio Simulations

2018 ◽  
Author(s):  
Qi Li ◽  
Adam J. Zaczek ◽  
Timothy M. Korter ◽  
J. Axel Zeitler ◽  
Michael T. Ruggiero
Keyword(s):  
Ab Initio ◽  
Metal Organic Frameworks ◽  
Low Frequency ◽  
Rotor Dynamics ◽  
Quantum Mechanical ◽  
Valuable Insight ◽  
Void Space ◽  
Ab Initio Simulations ◽  
Metal Organic ◽  
Insight Into

<div>Understanding the nature of the interatomic interactions present within the pores of metal-organic frameworks</div><div>is critical in order to design and utilize advanced materials</div><div>with desirable applications. In ZIF-8 and its cobalt analogue</div><div>ZIF-67, the imidazolate methyl-groups, which point directly</div><div>into the void space, have been shown to freely rotate - even</div><div>down to cryogenic temperatures. Using a combination of ex-</div><div>perimental terahertz time-domain spectroscopy, low-frequency</div><div>Raman spectroscopy, and state-of-the-art ab initio simulations,</div><div>the methyl-rotor dynamics in ZIF-8 and ZIF-67 are fully charac-</div><div>terized within the context of a quantum-mechanical hindered-</div><div>rotor model. The results lend insight into the fundamental</div><div>origins of the experimentally observed methyl-rotor dynamics,</div><div>and provide valuable insight into the nature of the weak inter-</div><div>actions present within this important class of materials.</div>

Molecular-level Insight into Unusual Low Pressure CO2 Affinity in Pillared Metal–Organic Frameworks

2013 ◽  
Vol 135 (19) ◽  
pp. 7172-7180 ◽  
Author(s):  
Nicholas C. Burtch ◽  
Himanshu Jasuja ◽  
David Dubbeldam ◽  
Krista S. Walton
Keyword(s):  
Molecular Level ◽  
Metal Organic Frameworks ◽  
Low Pressure ◽  
Metal Organic ◽  
Insight Into

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Sign in / Sign up

Export Citation Format

Share Document