scholarly journals Synthesis, characterisation and functionalisation of BAB-type dual-responsive nanocarriers for targeted drug delivery: evolution of nanoparticles based on 2-vinylpyridine and diethyl vinylphosphonate

RSC Advances ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 1586-1594
Author(s):  
Andreas Saurwein ◽  
Andreas Schaffer ◽  
Christina Wieser ◽  
Bernhard Rieger
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Block Copolymers ◽  
Targeted Drug Delivery ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Diethyl Vinylphosphonate

Defined, stable nanoparticles were synthesised from block copolymers generated via REM-GTP and functionalised with folic acid.

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Smart pH- and reduction-dual-responsive folate–PEG-coated polymeric lipid vesicles for tumor-triggered targeted drug delivery

Nanoscale ◽  
2014 ◽  
Vol 6 (13) ◽  
pp. 7635 ◽  
Author(s):  
Sheng Wang ◽  
Hanjie Wang ◽  
Zhongyun Liu ◽  
Liangliang Wang ◽  
Xiaomin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Lipid Vesicles ◽  
Dual Responsive ◽  
Targeted Drug

Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

2018 ◽  
Vol 92 ◽  
pp. 892-901 ◽  
Author(s):  
Marziyeh Poshteh Shirani ◽  
Behzad Rezaei ◽  
Taghi Khayamian ◽  
Mohammad Dinari ◽  
Fazileh Hosseini Shamili ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Carbon Dot ◽  
Targeted Drug

Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery

2015 ◽  
Vol 380 ◽  
pp. 315-320 ◽  
Author(s):  
Tejabhiram Yadavalli ◽  
Shivaraman Ramasamy ◽  
Gopalakrishnan Chandrasekaran ◽  
Isaac Michael ◽  
Helen Annal Therese ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Dual Responsive ◽  
Targeted Drug
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