scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. and conjugated epirubicin: targeted drug delivery for treatment of breast cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 26874-26882 ◽  
Author(s):  
C. Senthil Kumar ◽  
Ayyavu Mahesh ◽  
M. Gover Antoniraj ◽  
S. Vaidevi ◽  
K. Ruckmani
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Fruit Extract ◽  
Site Specific ◽  
Targeted Drug ◽  
Limonia Acidissima ◽  
Mcf 7

Green synthesis of AuNPs using extract ofLimonia acidissimaL. as a reducing agent. Epirubicin was successfully loaded on folic acid–AuNPs. This formulation revealed better site specific delivery of epirubicin to MCF-7 cells.

Biocompatible magnetic tris(2-aminoethyl)amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate

2017 ◽  
Vol 41 (5) ◽  
pp. 2160-2168 ◽  
Author(s):  
Mahdi Rahimi ◽  
Salman Shojaei ◽  
Kazem D. Safa ◽  
Zarrin Ghasemi ◽  
Roya Salehi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Amine Functionalized ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A smart, pH-responsive and biocompatible nanocarrier, aimed to achieve an efficient targeted drug delivery system, was facilely synthesized.

Dual Functionalized Janus Nanocomposites for Targeted pH-Responsive Drug Delivery

2014 ◽  
Vol 1625 ◽  
Author(s):  
Feng Wang ◽  
Giovanni Pauletti ◽  
Yilong Wang ◽  
Donglu Shi
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Functional Groups ◽  
Targeted Drug Delivery ◽  
Medical Diagnosis ◽  
Diagnosis And Treatment ◽  
Release Mechanism ◽  
Ph Responsive ◽  
Targeted Drug

ABSTRACTA superparamagnetic Janus nanocomposite (SJNC) of polystyrene/Fe3O4@SiO2 was designed and developed with dual surface bearing functional groups for medical diagnosis and treatment. Folic acid (FA) and doxorubicin (DOX) were conjugated stepwise to the surfaces. SJNCs were found to enable simultaneous cell-targeted drug delivery via pH-responsive release mechanism.

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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