Iron-catalyzed hydrogen atom transfer induced cyclization of 1,6-enynes for the synthesis of ketoximes: a combined experimental and computational study

2021 ◽  
Author(s):  
Mingming Zhao ◽  
Wei He ◽  
Liang-Hua Zou ◽  
Dawei Wang ◽  
Tian-Yu Sun ◽  
...  
Keyword(s):  
Hydrogen Atom ◽  
Computational Study ◽  
Hydrogen Atom Transfer ◽  
Radical Cyclization ◽  
Atom Transfer

An iron-catalyzed reductive radical cyclization/hydro-oximation of 1,6-enynes with tBuONO was developed, leading to functionalized benzofuran, benzothiophene, and cyclopentenyl-based ketoximes.

scholarly journals Concise Total Synthesis of (+)-Aphanorphine

Synlett ◽  
2021 ◽  
Author(s):  
Yukun Guan ◽  
Cheng Wang
Keyword(s):  
Hydrogen Atom ◽  
Total Synthesis ◽  
Hydrogen Atom Transfer ◽  
Radical Cyclization ◽  
Atom Transfer ◽  
Key Features ◽  
Form Ring

AbstractA concise total synthesis of (+)-aphanorphine is described. The key features of the strategy include a Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition to form ring C and a Co-catalyzed radical cyclization through a hydrogen-atom transfer to close ring B. The synthesis was completed in six steps.

Radical Cyclization of Alkene-Tethered Ketones Initiated by Hydrogen-Atom Transfer

2017 ◽  
Vol 130 (1) ◽  
pp. 188-192 ◽  
Author(s):  
Mar Saladrigas ◽  
Caroline Bosch ◽  
Gisela V. Saborit ◽  
Josep Bonjoch ◽  
Ben Bradshaw
Keyword(s):  
Hydrogen Atom ◽  
Hydrogen Atom Transfer ◽  
Radical Cyclization ◽  
Atom Transfer
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