Functional terpyridyl iron complexes for in vivo photoacoustic imaging

2020 ◽  
Vol 7 (15) ◽  
pp. 2753-2758
Author(s):  
Pan Xiang ◽  
Yu Shen ◽  
Jie Shen ◽  
Zhihui Feng ◽  
Min Sun ◽  
...  
Keyword(s):  
High Resolution ◽  
Photoacoustic Imaging ◽  
Iron Complexes ◽  
Recent Decade ◽  
Tissue Penetration ◽  
Deep Tissue

Photoacoustic (PA) imaging has received extensive attention in the recent decade due to its ultra-high resolution in deep tissue penetration.

Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and NIR-I Photoacoustic Imaging

2021 ◽  
Author(s):  
Yaxi Li ◽  
Hongli Zhou ◽  
Renzhe Bi ◽  
Xiuting Li ◽  
Menglei Zha ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Molecule ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Infrared Window

Fluorescence imaging in the second near-infrared window (NIR-II) has been an emerging technique in diverse in vivo applications with high sensitivity/resolution and deep tissue penetration. To date, the designing principle...

scholarly journals Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

2018 ◽  
Vol 9 (10) ◽  
pp. 2705-2710 ◽  
Author(s):  
Wei Qin ◽  
Pengfei Zhang ◽  
Hui Li ◽  
Jacky W. Y. Lam ◽  
Yuanjing Cai ◽  
...  
Keyword(s):  
High Resolution ◽  
Vascular Imaging ◽  
Tissue Imaging ◽  
Deep Penetration ◽  
High Contrast ◽  
Deep Tissue ◽  
Two Photon ◽  
High Penetration ◽  
Deep Tissue Imaging

A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast.

scholarly journals Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

2020 ◽  
Vol 13 (03) ◽  
pp. 2030005
Author(s):  
Zhao Lei ◽  
Yun Zeng ◽  
Xiaofen Zhang ◽  
Xiaoyong Wang ◽  
Gang Liu
Keyword(s):  
Molecular Imaging ◽  
Fluorescent Proteins ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Reporter Genes ◽  
Biological Processes ◽  
Deep Tissue ◽  
Potential Applications ◽  
Improved Performance

Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene’s expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies about the existing photoacoustic reporter genes (RGs) for noninvasive molecular imaging, such as the pigment enzyme reporters, fluorescent proteins and chromoproteins, photoswitchable proteins, including their properties and potential applications in theranostics. Furthermore, the challenges that PAI RGs face when applied to the clinical studies are also examined.

Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging

2019 ◽  
Vol 26 (21) ◽  
pp. 4029-4041 ◽  
Author(s):  
Hai-Yan Wang ◽  
Huisheng Zhang ◽  
Siping Chen ◽  
Yi Liu
Keyword(s):  
Near Infrared ◽  
Living System ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Biological Targets ◽  
Nir Dyes ◽  
Photo Damage ◽  
Temporal And Spatial

Luminescence bioimaging is widely used for noninvasive monitoring of biological targets in real-time with high temporal and spatial resolution. For efficient bioimaging in vivo, it is essential to develop smart organic dye platforms. Fluorescein (FL), a traditional dye, has been widely used in the biological and clinical studies. However, visible excitation and emission limited their further application for in vivo bioimaging. Nearinfrared (NIR) dyes display advantages of bioimaging because of their minimum absorption and photo-damage to biological samples, as well as deep tissue penetration and low auto-luminescence from background in the living system. Thus, some great developments of near-infrared fluorescein-inspired dyes have emerged for bioapplication in vitro and in vivo. In this review, we highlight the advances in the development of the near-infrared chemodosimeters for detection and bioimaging based on the modification of fluoresceininspired dyes naphtho-fluorescein (NPF) and cyanine-fluorescein (Cy-FL).

scholarly journals Lensless high-resolution photoacoustic imaging scanner for in vivo skin imaging

2017 ◽  
Vol 25 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Taiichiro Ida ◽  
Hideaki Iwazaki ◽  
Toshiyuki Omuro ◽  
Yasushi Kawaguchi ◽  
Yasuyuki Tsunoi ◽  
...  
Keyword(s):  
High Resolution ◽  
Photoacoustic Imaging ◽  
Skin Imaging

A novel self-targeting theranostic nanoplatform for photoacoustic imaging-monitored and enhanced chemo-sonodynamic therapy

2021 ◽  
Author(s):  
Yifan Yang ◽  
Zhongxiong Fan ◽  
Kaili Zheng ◽  
Dao Shi ◽  
Guanghao Su ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Blood Clearance ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Sonodynamic Therapy ◽  
Noninvasive Therapy

Sonodynamic therapy has attracted wide attention as a noninvasive therapy due to deep tissue penetration. However, the majority of sonosensitizers often suffer from poor physiological stability, rapid blood clearance and...

scholarly journals Direct focus sensing and shaping for high-resolution multi-photon imaging in deep tissue

2021 ◽  
Author(s):  
Jianan Qu ◽  
ZHONGYA QIN ◽  
ZHENTAO SHE ◽  
CONGPING CHEN ◽  
WANJIE WU ◽  
...  
Keyword(s):  
High Resolution ◽  
Adaptive Optics ◽  
High Sensitivity ◽  
Deep Tissue ◽  
Non Invasive ◽  
Mouse Cortex ◽  
Intact Brain ◽  
Resolution Imaging

High-resolution optical imaging of deep tissue in-situ such as the living brain is fundamentally challenging because of the aberration and scattering of light. In this work, we develop an innovative adaptive optics three-photon microscope based on direct focus sensing and shaping that can accurately measure and effectively compensate for both low- and high-order specimen-induced aberrations and recover near-diffraction-limited performance at depth. A conjugate adaptive optics configuration with remote focusing enables in vivo imaging of fine neuronal structures in the mouse cortex through the intact skull up to a depth of 750 um below pia, making high-resolution microscopy in cortex near non-invasive. Functional calcium imaging with high sensitivity and accuracy, and high-precision laser-mediated microsurgery through the intact skull were demonstrated. Moreover, we also achieved in vivo high-resolution imaging of the deep cortex and subcortical hippocampus up to 1.1 mm below pia within the intact brain.

Second Near-Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Fei Wang ◽  
Xiaoju Men ◽  
Haobin Chen ◽  
Feixue Mi ◽  
Mengze Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Tissue Penetration ◽  
Biocompatible Polymer ◽  
Cancer Theranostics ◽  
Maximum Permissible Exposure

Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) has drawn considerable attention due to the deeper tissue penetration and higher maximum permissible exposure. However, current phototheranostic agents are greatly restricted to the...

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