Second Near-Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Fei Wang ◽  
Xiaoju Men ◽  
Haobin Chen ◽  
Feixue Mi ◽  
Mengze Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Tissue Penetration ◽  
Biocompatible Polymer ◽  
Cancer Theranostics ◽  
Maximum Permissible Exposure

Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) has drawn considerable attention due to the deeper tissue penetration and higher maximum permissible exposure. However, current phototheranostic agents are greatly restricted to the...

Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

2017 ◽  
Vol 5 (2) ◽  
pp. 382-387 ◽  
Author(s):  
Yuping Yan ◽  
Qi Yang ◽  
Jie Wang ◽  
Hongyu Jin ◽  
Jing Wang ◽  
...  
Keyword(s):  
Light Absorption ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Step Process ◽  
Theranostic Agent ◽  
Nir Light ◽  
Doped Polymer

We report a two-step process to construct heteropoly blue (HPB) doped polymer nanoparticles with efficient near-infrared (NIR) light absorption and photothermal conversion efficiency of ∼23%.

scholarly journals Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Chuangjia Huang ◽  
Xiaoling Guan ◽  
Hui Lin ◽  
Lu Liang ◽  
Yingling Miao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Near Infrared ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Good Biocompatibility ◽  
Targeting Ability ◽  
Body Clearance

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

scholarly journals Multifunctional conjugated polymer nanoparticles for photoacoustic-based multimodal imaging and cancer photothermal therapy

2019 ◽  
Vol 12 (03) ◽  
pp. 1930001 ◽  
Author(s):  
Xiaoju Men ◽  
Zhen Yuan
Keyword(s):  
Conjugated Polymer ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Photoacoustic Imaging ◽  
Biological Tissues ◽  
Polymer Nanoparticles ◽  
Imaging Method ◽  
Conjugated Polymer Nanoparticles ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Photoacoustic imaging (PAI) is a hybrid imaging method based on photoacoustic (PA) effects, which is able to capture the structure, function, and molecular information of biological tissues with high resolution. To date, therapeutic techniques under the guidance of PAI have provided new strategies for accurate diagnosis and precise treatment of tumors. In particular, conjugated polymer nanoparticles have been extensively inspected for PA-based cancer theranostics largely due to their superior optical properties such as tunable spectrum and large absorption coefficient and their good biocompatibility, and abundant functional groups. This mini-review mainly focuses on the recent advances toward the development of novel conjugated polymer nanoparticles for PA-based multimodal imaging and cancer photothermal therapy.

Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics

2018 ◽  
Vol 30 (39) ◽  
pp. 1802105 ◽  
Author(s):  
Dong Wang ◽  
Michelle M. S. Lee ◽  
Guogang Shan ◽  
Ryan T. K. Kwok ◽  
Jacky W. Y. Lam ◽  
...  
Keyword(s):  
Near Infrared ◽  
Aggregation Induced Emission ◽  
Highly Efficient ◽  
Cancer Theranostics

Correction: In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2013 ◽  
Vol 25 (7) ◽  
pp. 945-945 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles

scholarly journals Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Jun Yao ◽  
Chuanda Zhu ◽  
Tianjiao Peng ◽  
Qiang Ma ◽  
Shegan Gao
Keyword(s):  
Titanium Carbide ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Therapeutic Strategy ◽  
Near Infrared ◽  
Pluronic F127 ◽  
Temperature Sensitive ◽  
Hydrogel System

Recently, organic–inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (Ti3C2) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate Ti3C2 nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The Ti3C2 nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, Ti3C2 nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of Ti3C2 nanoparticles. The in vitro and in vivo results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention in vivo and elevating the local temperature in tumors.

scholarly journals Pillar[5]arene-Modified Gold Nanorods as Nanocarriers for Multi-Modal Imaging-Guided Synergistic Photodynamic-Photothermal Therapy

2020 ◽  
Author(s):  
Nan Song ◽  
Zhijun Zhang ◽  
Peiying Liu ◽  
Dihua Dai ◽  
Chao Chen ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
High Performance ◽  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Functional Materials ◽  
Ros Generation ◽  
Cancer Therapies ◽  
New Strategy

Supramolecular approaches have opened up vast possibilities in the construction of versatile functional materials, especially those with stimuli-responsiveness and integrated functionalities of multi-modal diagnosis and synergistic therapeutics. In this study, a hybrid theranostic nanosystem named TTPY-PyÌCP5@AuNR is constructed via facile host-guest interactions, where TTPY-Py is a photosensitizer with aggregation-induced emission and CP5@AuNR represents the carboxylatopillar[5]arene (CP5)-modified Au nanorods. TTPY-PyÌCP5@AuNR integrates the respective advantages of TTPY-Py and CP5@AuNR such as the high performance of reactive oxygen species (ROS) generation and photothermal conversion, and meanwhile shows fluorescence responses to both temperature and pH stimuli due to the non-covalent interactions. The successful modification of CP5 macrocycles on AuNRs surfaces can eliminate the cytotoxicity of AuNRs and enable them to serve as the nanocarrier of TTPY-Py for further theranostic application. Significantly, both in vitro and in vivo evaluations demonstrate that this supramolecular nanotheranostic system possesses multiple phototheranostic modalities including intensive fluorescence imaging (FLI), photoacoustic imaging (PAI), efficient photodynamic therapy (PDT), and photothermal therapy (PTT), indicating its great potentials for FLI-PAI imaging-guided synergistic PDT-PTT therapy. Besides, TTPY-Py can be released from the nanocarriers upon activating by the acidic environment of lysosomes and then specifically light up mitochondria. This study brings up a new strategy into the design of versatile nanotheranostics for accurate tumor imaging and cancer therapies.

Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging

2019 ◽  
Vol 26 (21) ◽  
pp. 4029-4041 ◽  
Author(s):  
Hai-Yan Wang ◽  
Huisheng Zhang ◽  
Siping Chen ◽  
Yi Liu
Keyword(s):  
Near Infrared ◽  
Living System ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Biological Targets ◽  
Nir Dyes ◽  
Photo Damage ◽  
Temporal And Spatial

Luminescence bioimaging is widely used for noninvasive monitoring of biological targets in real-time with high temporal and spatial resolution. For efficient bioimaging in vivo, it is essential to develop smart organic dye platforms. Fluorescein (FL), a traditional dye, has been widely used in the biological and clinical studies. However, visible excitation and emission limited their further application for in vivo bioimaging. Nearinfrared (NIR) dyes display advantages of bioimaging because of their minimum absorption and photo-damage to biological samples, as well as deep tissue penetration and low auto-luminescence from background in the living system. Thus, some great developments of near-infrared fluorescein-inspired dyes have emerged for bioapplication in vitro and in vivo. In this review, we highlight the advances in the development of the near-infrared chemodosimeters for detection and bioimaging based on the modification of fluoresceininspired dyes naphtho-fluorescein (NPF) and cyanine-fluorescein (Cy-FL).

Second near-infrared (NIR-II) imaging: a novel diagnostic technique for brain diseases

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Na Xie ◽  
Ya Hou ◽  
Shaohui Wang ◽  
Xiaopeng Ai ◽  
Jinrong Bai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Tumor ◽  
Near Infrared ◽  
Diagnostic Technique ◽  
High Sensitivity ◽  
Brain Diseases ◽  
Tissue Penetration ◽  
Tumor Inflammation

Abstract Imaging in the second near-infrared II (NIR-II) window, a kind of biomedical imaging technology with characteristics of high sensitivity, high resolution, and real-time imaging, is commonly used in the diagnosis of brain diseases. Compared with the conventional visible light (400–750 nm) and NIR-I (750–900 nm) imaging, the NIR-II has a longer wavelength of 1000–1700 nm. Notably, the superiorities of NIR-II can minimize the light scattering and autofluorescence of biological tissue with the depth of brain tissue penetration up to 7.4 mm. Herein, we summarized the main principles of NIR-II in animal models of traumatic brain injury, cerebrovascular visualization, brain tumor, inflammation, and stroke. Simultaneously, we encapsulated the in vivo process of NIR-II probes and their in vivo and in vitro toxic effects. We further dissected its limitations and following optimization measures.

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