Injectable dual cross-linked adhesive hyaluronic acid multifunctional hydrogel scaffolds for potential applications in cartilage repair

2020 ◽  
Vol 11 (18) ◽  
pp. 3169-3178
Author(s):  
Chenxi Yu ◽  
Huichang Gao ◽  
Qingtao Li ◽  
Xiaodong Cao
Keyword(s):  
Hyaluronic Acid ◽  
Mechanical Strength ◽  
Cartilage Repair ◽  
Click Reaction ◽  
Diels Alder ◽  
Hydrogel Scaffolds ◽  
Potential Applications

A double crosslinked hydrogels was designed and prepared by combining the Diels–Alder click reaction and possessed good mechanical strength, injectability and adhesion.

scholarly journals Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 405-412 ◽  
Author(s):  
Maria M. Pérez-Madrigal ◽  
Joshua E. Shaw ◽  
Maria C. Arno ◽  
Judith A. Hoyland ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Mechanical Performance ◽  
Click Reaction ◽  
Load Bearing ◽  
Hydrogel Scaffolds ◽  
Soft Tissue Engineering

Combining two biopolymers with the efficiency and rapid nature of the thiol–yne click reaction yields biocompatible matrices with superior properties.

Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation

2018 ◽  
Vol 6 (10) ◽  
pp. 2578-2581 ◽  
Author(s):  
Yajie Zhang ◽  
Hong Chen ◽  
Tingting Zhang ◽  
Yue Zan ◽  
Tianyu Ni ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Osteogenic Differentiation ◽  
Click Reaction ◽  
Diels Alder ◽  
Bioorthogonal Reaction ◽  
Inverse Electron Demand ◽  
Electron Demand

An injectable in situ fast-forming hydrogel was fabricated to encapsulate BMSCs for osteogenic differentiation through the inverse electron demand Diels–Alder click reaction between trans-cyclooctene-modified PEG and tetrazine-modified hyaluronic acid.

scholarly journals Combining canine mesenchymal stromal cells and hyaluronic acid for cartilage repair

2020 ◽  
Vol 43 (1) ◽  
Author(s):  
Maria Inês Wits ◽  
Gabriela Cabanas Tobin ◽  
Maiele Dornelles Silveira ◽  
Karine Gehlen Baja ◽  
Luisa Maria Macedo Braga ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Mesenchymal Stromal Cells ◽  
Cartilage Repair ◽  
Stromal Cells

scholarly journals Correction: An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”

2018 ◽  
Vol 9 (28) ◽  
pp. 3959-3960 ◽  
Author(s):  
Feng Yu ◽  
Xiaodong Cao ◽  
Yuli Li ◽  
Lei Zeng ◽  
Bo Yuan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Cartilage Tissue Engineering ◽  
Diels Alder ◽  
Cartilage Tissue

Correction for ‘An injectable hyaluronic acid/PEG hydrogel for cartilage tissue engineering formed by integrating enzymatic crosslinking and Diels–Alder “click chemistry”’ by Feng Yu et al., Polym. Chem., 2014, 5, 1082–1090.

Near-infrared light-responsive, diselenide containing core-cross-linked micelles prepared by the Diels–Alder click reaction for photocontrollable drug release application

2018 ◽  
Vol 9 (39) ◽  
pp. 4813-4823 ◽  
Author(s):  
Sabrina Aufar Salma ◽  
Maheshkumar Prakash Patil ◽  
Dong Woo Kim ◽  
Cuong Minh Quoc Le ◽  
Byung-Hyun Ahn ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Click Reaction ◽  
Diels Alder ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Micelle System ◽  
Drug Vehicle

We report a facile and efficient preparation of a NIR-triggered micelle system for a drug vehicle.

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

Drug Research ◽  
2019 ◽  
Vol 70 (01) ◽  
pp. 6-11 ◽  
Author(s):  
Elham Ahmadian ◽  
Solmaz Maleki Dizaj ◽  
Aziz Eftekhari ◽  
Elaheh Dalir ◽  
Parviz Vahedi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Wound Repair ◽  
Stem Cell Differentiation ◽  
Clinical Applications ◽  
Cellular Behavior ◽  
Hydrogel Formation ◽  
Potential Applications ◽  
Basic Concepts ◽  
Elastic Sheets

AbstractHyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.

An injectable BMSC-laden enzyme-catalyzed crosslinking collagen-hyaluronic acid hydrogel for cartilage repair and regeneration

2020 ◽  
Vol 8 (19) ◽  
pp. 4237-4244 ◽  
Author(s):  
Yajie Zhang ◽  
Yi Cao ◽  
Hongbo Zhao ◽  
Liwei Zhang ◽  
Tianyu Ni ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Repair ◽  
Hyaluronic Acid Hydrogel

An injectable BMSC-laden collagen-hyaluronic acid hydrogel crosslinked by an enzyme-catalyzed reaction was generated for cartilage repair.

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