scholarly journals Robust alginate/hyaluronic acid thiol–yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

2020 ◽  
Vol 8 (1) ◽  
pp. 405-412 ◽  
Author(s):  
Maria M. Pérez-Madrigal ◽  
Joshua E. Shaw ◽  
Maria C. Arno ◽  
Judith A. Hoyland ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Mechanical Performance ◽  
Click Reaction ◽  
Load Bearing ◽  
Hydrogel Scaffolds ◽  
Soft Tissue Engineering

Combining two biopolymers with the efficiency and rapid nature of the thiol–yne click reaction yields biocompatible matrices with superior properties.

Epoxy-amine synthesised hydrogel scaffolds for soft-tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (25) ◽  
pp. 6454-6467 ◽  
Author(s):  
Zuratul A.A. Hamid ◽  
Anton Blencowe ◽  
Berkay Ozcelik ◽  
Jason A. Palmer ◽  
Geoffrey W. Stevens ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Hydrogel Scaffolds ◽  
Epoxy Amine ◽  
Soft Tissue Engineering

Hyaluronic acid/EDC/NHS-crosslinked green electrospun silk fibroin nanofibrous scaffolds for tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 99720-99728 ◽  
Author(s):  
Xingxing Yang ◽  
Xiaoyun Wang ◽  
Fan Yu ◽  
Linlin Ma ◽  
Xiaohan Pan ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Nanofibrous Scaffolds ◽  
Soft Tissue Engineering

The mechanical properties of SF nanofibrous matrices were enhanced through crosslinking with HA/EDC/NHS for soft tissue engineering.

scholarly journals Enzyme-Crosslinked Electrospun Fibrous Gelatin Hydrogel for Potential Soft Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1977
Author(s):  
Kexin Nie ◽  
Shanshan Han ◽  
Jianmin Yang ◽  
Qingqing Sun ◽  
Xiaofeng Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Water Solution ◽  
Cellular Adhesion ◽  
Fibrous Structure ◽  
Electrospun Fibers ◽  
Hydrogel Scaffolds ◽  
Cell Functions ◽  
Soft Tissue Engineering

Soft tissue engineering has been seeking ways to mimic the natural extracellular microenvironment that allows cells to migrate and proliferate to regenerate new tissue. Therefore, the reconstruction of soft tissue requires a scaffold possessing the extracellular matrix (ECM)-mimicking fibrous structure and elastic property, which affect the cell functions and tissue regeneration. Herein, an effective method for fabricating nanofibrous hydrogel for soft tissue engineering is demonstrated using gelatin–hydroxyphenylpropionic acid (Gel–HPA) by electrospinning and enzymatic crosslinking. Gel–HPA fibrous hydrogel was prepared by crosslinking the electrospun fibers in ethanol-water solution with an optimized concentration of horseradish peroxidase (HRP) and H2O2. The prepared fibrous hydrogel held the soft and elastic mechanical property of hydrogels and the three-dimensional (3D) fibrous structure of electrospun fibers. It was proven that the hydrogel scaffolds were biocompatible, improving the cellular adhesion, spreading, and proliferation. Moreover, the fibrous hydrogel showed rapid biodegradability and promoted angiogenesis in vivo. Overall, this study represents a novel biomimetic approach to generate Gel–HPA fibrous hydrogel scaffolds which have excellent potential in soft tissue regeneration applications.

Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering

Biomaterials ◽  
2005 ◽  
Vol 26 (34) ◽  
pp. 7025-7037 ◽  
Author(s):  
Karsten Hemmrich ◽  
Dennis von Heimburg ◽  
Raoul Rendchen ◽  
Chiara Di Bartolo ◽  
Eva Milella ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Soft Tissue ◽  
Nude Mice ◽  
Soft Tissue Engineering
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