Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation

2018 ◽  
Vol 6 (10) ◽  
pp. 2578-2581 ◽  
Author(s):  
Yajie Zhang ◽  
Hong Chen ◽  
Tingting Zhang ◽  
Yue Zan ◽  
Tianyu Ni ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Osteogenic Differentiation ◽  
Click Reaction ◽  
Diels Alder ◽  
Bioorthogonal Reaction ◽  
Inverse Electron Demand ◽  
Electron Demand

An injectable in situ fast-forming hydrogel was fabricated to encapsulate BMSCs for osteogenic differentiation through the inverse electron demand Diels–Alder click reaction between trans-cyclooctene-modified PEG and tetrazine-modified hyaluronic acid.

scholarly journals Bio-orthogonal “click-and-release” donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S)

2017 ◽  
Vol 53 (8) ◽  
pp. 1378-1380 ◽  
Author(s):  
Andrea K. Steiger ◽  
Yang Yang ◽  
Maksim Royzen ◽  
Michael D. Pluth
Keyword(s):  
Hydrogen Sulfide ◽  
Click Reaction ◽  
Carbonyl Sulfide ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
New Strategy ◽  
Electron Demand

The inverse-electron demand Diels–Alder (IEDDA) click reaction between thiocarbamate-functionalized trans-cyclooctenes and tetrazines provides a new strategy for bio-orthogonal COS/H2S delivery.

Diastereoselective Synthesis of Functionalized Tetrahydropyridazines Containing Indole Scaffolds via Inverse-Electron-Demand Aza-Diels–Alder Reaction

2021 ◽  
Author(s):  
Taotao Chen ◽  
Chao Che ◽  
Zhefei Guo ◽  
Xiu-Qin Dong ◽  
Chun-Jiang Wang
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Inverse Electron Demand ◽  
Catalyst Free ◽  
Diels Alder Reaction ◽  
Electron Demand

An unprecedented base-promoted and catalyst-free inverse-electron-demand aza-Diels-Alder (IEDDA) reaction between the easily available in situ generated azoalkenes and 3-vinylindoles has been developed. This efficient protocol afforded structurally important tetrahydropyridazines containing...

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