A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-amines via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water

2020 ◽  
Vol 18 (37) ◽  
pp. 7425-7430
Author(s):  
Jinli Zhang ◽  
Ling Chen ◽  
Yibo Dong ◽  
Jinchen Yang ◽  
Yangjie Wu
Keyword(s):  
One Pot ◽  
Efficient Approach ◽  
Aryl Isothiocyanates

An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed.

One-Pot Synthesis and Conformational Analysis of 6-Membered Cyclic Iodonium Salts

2020 ◽  
Author(s):  
Lucien Caspers ◽  
Julian Spils ◽  
Mattis Damrath ◽  
Enno Lork ◽  
Boris Nachtsheim
Keyword(s):  
Conformational Analysis ◽  
Bronsted Acids ◽  
One Pot ◽  
Benzyl Alcohols ◽  
Iodonium Salts ◽  
Efficient Approach ◽  
One Pot Synthesis ◽  
Diaryliodonium Salts

In this article we describe an efficient approach for the synthesis of cyclic diaryliodonium salts. The method is based on benzyl alcohols as starting materials and consists of an Friedel-Crafts-arylation/oxidation sequence. Besides a deep optimization, particluar focusing on the choice and ratios of the utilized Bronsted-acids and oxidants, we explore the substrate scope of this transformation. We also discuss an interesting isomerism of cyclic iodonium salts substituted with aliphatic substituents at the bridge head carbon. <br>

An efficient approach towards three component coupling of one pot reaction for synthesis of functionalized benzopyrans

2006 ◽  
Vol 43 (6) ◽  
pp. 1691-1693 ◽  
Author(s):  
B. Sunil Kumar ◽  
N. Srinivasulu ◽  
R. H. Udupi ◽  
B. Rajitha ◽  
Y. Thirupathi Reddy ◽  
...  
Keyword(s):  
One Pot ◽  
Efficient Approach ◽  
Three Component Coupling

CuSO4–d-glucose, an inexpensive and eco-efficient catalytic system: direct access to diverse quinolines through modified Friedländer approach involving SNAr/reduction/annulation cascade in one pot

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7654-7660 ◽  
Author(s):  
Namrata Anand ◽  
Tanmoy Chanda ◽  
Suvajit Koley ◽  
Sushobhan Chowdhury ◽  
Maya Shankar Singh
Keyword(s):  
Catalytic System ◽  
Direct Access ◽  
One Pot ◽  
Efficient Approach

A one-pot, efficient approach to quinoline synthesis, directly from 2-bromoaromatic aldehydes/ketones in a H2O–EtOH mixture involving a sequence of SNAr/reduction/annulation cascade using CuSO4-d-glucose, is devised.

scholarly journals Catalytic coproduction of methanol and glycol in one pot from epoxide, CO2, and H2

RSC Advances ◽  
2020 ◽  
Vol 10 (69) ◽  
pp. 42557-42563
Author(s):  
Jotheeswari Kothandaraman ◽  
David J. Heldebrant
Keyword(s):  
Energy Efficient ◽  
One Pot ◽  
Efficient Approach ◽  
Commodity Chemicals ◽  
First Time

An atom (100%) and energy-efficient approach to coproduce two commodity chemicals, methanol and glycol, has been demonstrated for the first time using H2, CO2, and epoxide as feeds.

One-Pot Synthesis of Thiazolo[3,4-a]Quinoxalines from 1,2-Diamines, Aryl Isothiocyanates and Ethyl Bromopyruvate

2017 ◽  
Vol 41 (12) ◽  
pp. 712-714 ◽  
Author(s):  
Mohammad Piltan
Keyword(s):  
Chromatographic Separations ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
Wide Range ◽  
Quinoxaline Derivatives ◽  
First Time ◽  
Aryl Isothiocyanates ◽  
Ethyl Bromopyruvate

Some hitherto unreported thiazolo[3,4- a]quinoxaline derivatives have been synthesised in excellent yields via a one-pot, three-component reaction of benzene-1,2-diamines, ethyl bromopyruvate and aryl isothiocyanates in MeCN, for the first time. The protocol avoids the use of any catalysts or chromatographic separations and provides a wide range of novel thiazolo[3,4- a]quinoxalines.

Multicomponent assembling of isatins, malononitrile and 4-hydroxy-6-methylpyridin-2(1H)-ones: one-pot efficient approach to privileged spiro[indoline-3,4’-pyrano[3,2-c]pyridine]-2,5’(6’H)-dione scaffold

2016 ◽  
Vol 26 (5) ◽  
pp. 399-401 ◽  
Author(s):  
Michail N. Elinson ◽  
Fedor V. Ryzhkov ◽  
Anatoly N. Vereshchagin ◽  
Tatiana A. Zaimovskaya ◽  
Victor A. Korolev ◽  
...  
Keyword(s):  
One Pot ◽  
Efficient Approach

An efficient approach to 3-oxoisoindoline-1-difluoroalkyl derivatives via a metal triflate-catalyzed Mannich/lactamization cascade reaction

2017 ◽  
Vol 41 (7) ◽  
pp. 2519-2522 ◽  
Author(s):  
Tingting Chen ◽  
Chun Cai
Keyword(s):  
Cascade Reaction ◽  
One Pot ◽  
Efficient Approach

An efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-difluoroalkyl derivatives via a one-pot cascade reaction has been developed.

A catalyst-free approach to 3-thiocyanato-4H-chromen-4-ones

RSC Advances ◽  
2016 ◽  
Vol 6 (70) ◽  
pp. 66320-66323 ◽  
Author(s):  
Xiao-Zhuan Zhang ◽  
Dao-Liang Ge ◽  
Shan-Yong Chen ◽  
Xiao-Qi Yu
Keyword(s):  
Room Temperature ◽  
One Pot ◽  
Efficient Approach ◽  
Catalyst Free ◽  
One Pot Synthesis

A facile and efficient approach to 3-thiocyanato-4H-chromen-4-ones from enaminones and KSCN was realized at room temperature. In addition, one-pot synthesis of 3-thiocyanatochromenones from 2-hydroxylacetophenones was also developed.

An Intramolecular Diels–Alder Furan (IMDAF) Approach towards the Synthesis of Isoindolo[2,1-a]quinazolines and Isoindolo[1,2-b]quinazolines

Synthesis ◽  
2017 ◽  
Vol 49 (16) ◽  
pp. 3749-3767 ◽  
Author(s):  
Vladimir Zaytsev ◽  
Ekaterina Revutskaya ◽  
Tatiana Nikanorova ◽  
Eugeniya Nikitina ◽  
Pavel Dorovatovskii ◽  
...  
Keyword(s):  
Unsaturated Acid ◽  
Nitrogen Heterocycles ◽  
Diels Alder ◽  
Isatoic Anhydride ◽  
One Pot ◽  
Efficient Approach ◽  
Condensation Reactions ◽  
Stereogenic Centers ◽  
Acid Anhydrides

An efficient approach to bridged pentacyclic nitrogen heterocycles via the tandem acylation/intramolecular Diels–Alder furan (IMDAF) reaction of 2-furylquinazolinones is described. Reactions of α,β-unsaturated acid anhydrides with 2-furyl-2,3-dihydroquinazolin-4-ones give 6b,9-epoxyisoindolo[2,1-a]quinazolines in average yields. In this case, the exo-IMDAF reactions proceed with excellent diastereoselectivity giving five stereogenic centers and three new rings in one synthetic step. Isomeric 2,4a-epoxyisoindolo[1,2-b]quinazolines are obtained by one-pot, three-component condensation reactions of allylamine, isatoic anhydride and furaldehydes involving the same IMDAF­ reaction as the key step. Some useful transformations including halogenation, hydrogenation, Prilezhaev epoxidation, and esterification of the synthesized epoxyisoindoloquinazolines are also demonstrated.

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