ChemInform Abstract: A Highly Efficient Approach to Unnatural Amino-Acids Containing 3-Hydroxyoxindole Skeleton via a One-Pot, Three-Component Procedure.

ChemInform ◽  
2015 ◽  
Vol 46 (22) ◽  
pp. no-no
Author(s):  
Huang Huang ◽  
Yong Xu ◽  
Fei Mao ◽  
Jin Zhu ◽  
Hualiang Jiang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Component Procedure

A highly efficient approach to unnatural amino-acids containing 3-hydroxyoxindole skeleton via a one-pot, three-component procedure

2015 ◽  
Vol 56 (4) ◽  
pp. 586-589 ◽  
Author(s):  
Huang Huang ◽  
Yong Xu ◽  
Fei Mao ◽  
Jin Zhu ◽  
Hualiang Jiang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Component Procedure

A highly efficient asymmetric synthesis of quaternary stereocenter-containing indolizidine and quinolizidine alkaloids using aldehydes, nitroalkenes, and unactivated cyclic ketimines

2014 ◽  
Vol 50 (100) ◽  
pp. 15913-15915 ◽  
Author(s):  
Yu Tan ◽  
Yong-Jian Chen ◽  
Hua Lin ◽  
Han-Lin Luan ◽  
Xing-Wen Sun ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Quinolizidine Alkaloids ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Quaternary Stereocenter

A highly efficient approach to the construction of indolizidines and quinolizidines bearing a bridged quaternary stereocenter has been established in a one-pot fashion using aldehydes, nitroalkenes, and cyclic ketimines.

scholarly journals A novel application of 2-silylated 1,3-dithiolanes for the synthesis of aryl/hetaryl-substituted ethenes and dibenzofulvenes

2017 ◽  
Vol 13 ◽  
pp. 1900-1906 ◽  
Author(s):  
Grzegorz Mlostoń ◽  
Paulina Pipiak ◽  
Róża Hamera-Fałdyga ◽  
Heinz Heimgartner
Keyword(s):  
Equimolar Amount ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
High Yields

Trimethylsilyldiazomethane (TMS-CHN2) reacts readily with hetaryl thioketones to give sterically crowded 2-trimethylsilyl-4,4,5,5-tetrahetaryl-1,3-dithiolanes with complete regioselectivity at −75 °C as well as at rt. Thiofluorenone, a relatively stable and highly reactive aryl thioketone, yields upon treatment with TMS-CHN2 at −60 °C the corresponding 1,3,4-thiadiazoline. This unstable cycloadduct undergoes decomposition at ca. −45 °C and the silylated thiocarbonyl S-methanide generated thereby is trapped with complete regioselectivity by aryl or hetaryl thioketones forming also sterically crowded 2-trimethylsilyl-1,3-dithiolanes. The obtained 1,3-dithiolanes, by treatment with an equimolar amount of TBAF in a one-pot procedure, are converted in high yields into hetaryl/aryl-substituted ethenes or dibenzofulvenes, respectively, via a cycloreversion reaction of the intermediate 1,3-dithiolane carbanion. The presented protocol offers a new, highly efficient approach to tetrasubstituted ethenes and dibenzofulvenes bearing aryl and/or hetaryl substituents.

One-pot synthesis of aryl glycines and other unnatural amino acids from serine derivatives

2002 ◽  
Vol 43 (46) ◽  
pp. 8269-8272 ◽  
Author(s):  
Alicia Boto ◽  
Rosendo Hernández ◽  
Adriana Montoya ◽  
Ernesto Suárez
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals Condensed E. coli cultures for highly efficient production of proteins containing unnatural amino acids

2010 ◽  
Vol 20 (19) ◽  
pp. 5613-5616 ◽  
Author(s):  
Jia Liu ◽  
Carlos A. Castañeda ◽  
Bryan J. Wilkins ◽  
David Fushman ◽  
T. Ashton Cropp
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
Efficient Production ◽  
E Coli ◽  
Highly Efficient

scholarly journals A Highly Efficient Approach to the Synthesis of Complex α-Glycosyl Phosphosaccharides

2021 ◽  
Author(s):  
Yugen Zhu ◽  
Xiaojuan Zhang ◽  
Yutong Yang ◽  
Jiahao Ding ◽  
Yun Zhao ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Leishmania Donovani ◽  
One Pot ◽  
Efficient Approach ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
The One

Abstract A highly efficient and stereoselective approach to the synthesis of biologically important and complex α-glycosyl phosphosaccharides (GPSs) has been disclosed, employing direct gold(I)-catalyzed glycosylation of the weakly nucleophilic phosphoric acid acceptors. The broad substrate scope is demonstrated with more than 45 examples, including glucose (Glc), xylose, glucouronatose, galactose (Gal), mannose (Man), rhamnose (Rha), fucose (Fuc), 2-N3-2-dexoxymannose (ManN3), 2-N3-2-dexoxyglucose (GlcN3), 2-N3-2-dexoxygalactose (GalN3) and unnatural carbohydrates. Moreover, the glycosyl phosphotriester prepared herein was successfully applied to the one-pot synthesis of a GPS from Leishmania donovani, and an effective preparation of a trisaccharide diphosphate of GPS fragments from Hansenula capsulate via iterative elongation strategy is realized.

Artificial Biocatalytic Cascade with Three Enzymes in One Pot for Asymmetric Synthesis of Chiral Unnatural Amino Acids

2019 ◽  
Vol 2019 (38) ◽  
pp. 6470-6477 ◽  
Author(s):  
Haisheng Zhou ◽  
Lijun Meng ◽  
Xinjian Yin ◽  
Yayun Liu ◽  
Gang Xu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unnatural Amino Acids ◽  
One Pot

One-Pot Synthesis of Aryl Glycines and Other Unnatural Amino Acids from Serine Derivatives.

ChemInform ◽  
2003 ◽  
Vol 34 (5) ◽  
Author(s):  
Alicia Boto ◽  
Rosendo Hernandez ◽  
Adriana Montoya ◽  
Ernesto Suarez
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
One Pot ◽  
One Pot Synthesis
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