Design of potent ABA receptor antagonists based on a conformational restriction approach

Jun Takeuchi; Hikaru Nagamiya; Sayaka Moroi; Toshiyuki Ohnishi; Yasushi Todoroki

doi:10.1039/d0ob01017k

Design of potent ABA receptor antagonists based on a conformational restriction approach

Organic & Biomolecular Chemistry ◽

10.1039/d0ob01017k ◽

2020 ◽

Vol 18 (26) ◽

pp. 4988-4996

Author(s):

Jun Takeuchi ◽

Hikaru Nagamiya ◽

Sayaka Moroi ◽

Toshiyuki Ohnishi ◽

Yasushi Todoroki

Keyword(s):

Abscisic Acid ◽

Receptor Antagonist ◽

Receptor Antagonists ◽

Conformational Restriction ◽

Acid Receptor ◽

Conformationally Restricted ◽

Aba Receptor ◽

Conformationally Restricted Analogs

Conformationally restricted analogs of (+)-PAO4, an abscisic acid receptor antagonist, were synthesized to improve its potency.

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Synthesis and Biological Activity of Conformationally Restricted Analogs of Milnacipran: (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an Efficient NoncompetitiveN-Methyl-d-aspartic Acid Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm960495w ◽

1996 ◽

Vol 39 (24) ◽

pp. 4844-4852 ◽

Cited By ~ 25

Author(s):

Satoshi Shuto ◽

Shizuka Ono ◽

Yukako Hase ◽

Yoshihito Ueno ◽

Tomohiro Noguchi ◽

...

Keyword(s):

Biological Activity ◽

Receptor Antagonist ◽

Aspartic Acid ◽

Acid Receptor ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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Conformationally restricted analogs of histamine H1 receptor antagonists, trans- and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine

Journal of Medicinal Chemistry ◽

10.1021/jm00223a020 ◽

1976 ◽

Vol 19 (1) ◽

pp. 117-122 ◽

Cited By ~ 5

Author(s):

Ahmed E. Ahmed ◽

Patrick E. Hanna ◽

Vernon R. Grund

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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Initial structure–activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.03.076 ◽

2004 ◽

Vol 14 (11) ◽

pp. 2735-2740 ◽

Cited By ~ 42

Author(s):

Brian H. Heasley ◽

Renata Jarosz ◽

Kevin R. Lynch ◽

Timothy L. Macdonald

Keyword(s):

Receptor Antagonist ◽

Lysophosphatidic Acid ◽

Initial Structure ◽

Receptor Antagonists ◽

Acid Receptor ◽

Lysophosphatidic Acid Receptor ◽

Structure Activity Relationships ◽

High Affinity ◽

Structure Activity

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Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline

Journal of Medicinal Chemistry ◽

10.1021/jm00255a027 ◽

1974 ◽

Vol 17 (9) ◽

pp. 1020-1023 ◽

Cited By ~ 11

Author(s):

Patrick E. Hanna ◽

Vernon R. Grund ◽

M. W. Anders

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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ChemInform Abstract: CONFORMATIONALLY RESTRICTED ANALOGS OF HISTAME H1 RECEPTOR ANTAGONISTS, 2-PHENYL- AND 2-BENZYL-1,2,3,4-TETRAHYDRO-4-DIMETHYLAMINOISOQUINOLINE

Chemischer Informationsdienst ◽

10.1002/chin.197501282 ◽

1975 ◽

Vol 6 (1) ◽

pp. no-no

Author(s):

P. E. HANNA ◽

V. R. GRUND ◽

M. W. ANDERS

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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Conformationally restricted analogs of histamine H1 receptor antagonists. trans- and cis-1,5-Diphenyl-3-dimethylaminopyrrolidine

Journal of Medicinal Chemistry ◽

10.1021/jm00267a001 ◽

1973 ◽

Vol 16 (9) ◽

pp. 963-968 ◽

Cited By ~ 12

Author(s):

Patrick E. Hanna ◽

Ahmed E. Ahmed

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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ChemInform Abstract: CONFORMATIONALLY RESTRICTED ANALOGS OF HISTAMINE H1 RECEPTOR ANTAGONISTS, TRANS- AND CIS-1-BENZYL-3-DIMETHYLAMINO-6-PHENYLPIPERIDINE

Chemischer Informationsdienst ◽

10.1002/chin.197617235 ◽

1976 ◽

Vol 7 (17) ◽

pp. no-no

Author(s):

A. E. AHMED ◽

P. E. HANNA ◽

V. R. GRUND

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Chemistry - A European Journal ◽

10.1002/chem.201806056 ◽

2019 ◽

Vol 25 (14) ◽

pp. 3496-3500 ◽

Cited By ~ 1

Author(s):

Yu Mikame ◽

Kazuko Yoshida ◽

Daisuke Hashizume ◽

Go Hirai ◽

Kazuo Nagasawa ◽

...

Keyword(s):

Abscisic Acid ◽

Receptor Antagonists ◽

Acid Receptor

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ChemInform Abstract: CONFORMATIONALLY RESTRICTED ANALOGS OF HISTAMIN H1 RECEPTOR ANTAGONISTS, TRANS- AND CIS-1,5-DIPHENYL-3-DIMETHYLAMINOPYRROLIDINE

Chemischer Informationsdienst ◽

10.1002/chin.197351248 ◽

1973 ◽

Vol 4 (51) ◽

pp. no-no

Author(s):

P. E. HANNA ◽

A. E. AHMED

Keyword(s):

H1 Receptor ◽

Receptor Antagonists ◽

Conformationally Restricted ◽

Conformationally Restricted Analogs

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The Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation

10.26226/morressier.59b63e3fd462b8029238929e ◽

2017 ◽

Author(s):

Kazuyuki Sakamoto

Keyword(s):

Cell Proliferation ◽

Receptor Antagonist ◽

Lysophosphatidic Acid ◽

Prostate Cell ◽

Acid Receptor ◽

Lysophosphatidic Acid Receptor ◽

Urethral Function

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