Immobilising hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core–shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy

Nanoscale ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 6499-6512
Author(s):  
Gaole Dai ◽  
Chun Kit K. Choi ◽  
Yimin Zhou ◽  
Qianqian Bai ◽  
Yu Xiao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Core Shell ◽  
Hairpin Dna ◽  
Microrna Detection ◽  
Boron Dipyrromethene

A novel nanosystem based on polydopamine-coated gold nanorods has been designed and fabricated for detection of oncogenic microRNA-21 and microRNA-21-mediated photodynamic therapy.

Highly effective photodynamic inactivation of E. coli using gold nanorods/SiO2 core–shell nanostructures with embedded verteporfin

2015 ◽  
Vol 51 (91) ◽  
pp. 16365-16368 ◽  
Author(s):  
Kostiantyn Turcheniuk ◽  
Volodymyr Turcheniuk ◽  
Charles-Henri Hage ◽  
Tetiana Dumych ◽  
Rostyslav Bilyy ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Virulent Strain ◽  
Silica Shell ◽  
Core Shell ◽  
Photodynamic Inactivation ◽  
E Coli ◽  
Shell Nanostructures ◽  
20 Nm

The potential of gold nanorods coated with a 20 nm silica shell loaded with verteporfin as efficient NIR nanostructures for photodynamic therapy to eradicate a virulent strain of E. coli associated with urinary tract infection is described.

Synthesis and photophysicochemical properties of BODIPY dye functionalized gold nanorods for use in antimicrobial photodynamic therapy

2016 ◽  
Vol 20 (08n11) ◽  
pp. 1016-1024 ◽  
Author(s):  
Gugu Kubheka ◽  
Imran Uddin ◽  
Edith Amuhaya ◽  
John Mack ◽  
Tebello Nyokong
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Gold Nanorods ◽  
Molecular Modelling ◽  
Quantum Yields ◽  
Antimicrobial Photodynamic Therapy ◽  
Boron Dipyrromethene

A series of boron dipyrromethene (BODIPY) dyes with properties that are ideal for a good photosensitizer have been prepared. Functionalization with bromine atoms and attachment to gold nanoparticles through a meso-aniline group results in high singlet oxygen quantum yields and low fluorescent quantum yields. Molecular modelling was used to analyze trends in the MO energies of various brominated aniline BODIPY dyes.

Core–shell gold nanorod@mesoporous-MOF heterostructures for combinational phototherapy

Nanoscale ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 131-137
Author(s):  
Zehao Zhou ◽  
Jian Zhao ◽  
Zhenghan Di ◽  
Bei Liu ◽  
Zhaohui Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Metal Organic Frameworks ◽  
Gold Nanorod ◽  
Core Shell ◽  
Tumor Treatment ◽  
Metal Organic

A core–shell heterostructure consisting of plasmonic gold nanorods and porphyrinic metal–organic frameworks is synthesized as a promising platform to combine photodynamic therapy and photothermal therapy for enhanced tumor treatment.

In vitro and in vivo photocytotoxicity of boron dipyrromethene difluoride for photodynamic therapy

2011 ◽  
Vol 8 (2) ◽  
pp. 191-192
Author(s):  
S.H. Lim ◽  
C. Thivierge ◽  
P. Nowak-Sliwinska ◽  
J. Han ◽  
H. van den Bergh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy

Nanoscale ◽  
2012 ◽  
Vol 4 (24) ◽  
pp. 7712 ◽  
Author(s):  
Tingting Zhao ◽  
Xiaoqin Shen ◽  
Lin Li ◽  
Zhenping Guan ◽  
Nengyue Gao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Imaging Agents ◽  
Two Photon

scholarly journals A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 28 ◽  
Author(s):  
Priyanga Dharmaratne ◽  
Ligang Yu ◽  
Roy Chi-Hang Wong ◽  
Ben Chun-Lap Chan ◽  
Kit-Man Lau ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Irritation ◽  
Scientific Basis ◽  
Positive Control ◽  
Methicillin Resistant ◽  
Boron Dipyrromethene ◽  
Mrsa Strains

Background: We report herein the synthesis of a novel dicationic boron dipyrromethene derivative (compound 3) which is symmetrically substituted with two trimethylammonium styryl groups. Methods: The antibacterial photodynamic activity of compound 3 was determined against sixteen methicillin-resistant Staphylococcus aureus (MRSA) strains, including four ATCC type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, and ATCC BAA-44), two mutant strains [AAC(6’)-APH(2”) and RN4220/pUL5054], and ten non-duplicate clinical strains of hospital- and communityassociated MRSA. Upon light irradiation, the minimum bactericidal concentrations of compound 3 were in the range of 1.56-50 µM against all the sixteen MRSA strains. Interestingly, compound 3 was not only more active than an analogue in which the ammonium groups are not directly connected to the pconjugated system (compound 4), but also showed significantly higher (p < 0.05) antibacterial potency than the clinically approved photosensitizer methylene blue. The skin irritation of compound 3 during topical application was tested on human 3-D skin constructs and proven to be non-irritant in vivo at concentrations below 1.250 mM. In the murine MRSA infected wound study, the colony forming unit reduction of compound 3 + PDT group showed significantly (p < 0.05) higher value (>2.5 log10) compared to other test groups except for the positive control. Conclusion: In conclusion, the present study provides a scientific basis for future development of compound 3 as a potent photosensitizer for photodynamic therapy for MRSA wound infection.

Smart assembly of Mn-ferrites/silica core–shell with fluorescein and gold nanorods: robust and stable nanomicelles for in vivo triple modality imaging

2018 ◽  
Vol 6 (19) ◽  
pp. 2993-2999 ◽  
Author(s):  
Ilaria Monaco ◽  
Paolo Armanetti ◽  
Erica Locatelli ◽  
Alessandra Flori ◽  
Mirko Maturi ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Core Shell ◽  
Smart Assembly ◽  
Silica Core

We report the synthesis of a resilient nanosystem (MnFe2O4@SiO2@GNRs@PMs) for magnetic–photoacoustic–optical triple-modality imaging.

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