scholarly journals Short-term angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16315-16329
Author(s):  
Pamela Swiatlowska ◽  
Jose L. Sanchez-Alonso ◽  
Catherine Mansfield ◽  
Denis Scaini ◽  
Yuri Korchev ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Short Term ◽  
Nanoscale Level

MechanoSICM is used to understand the role of angiotensin II on transverse Young's modulus at the nanoscale level.

Role of Nitric Oxide in Short-term and Prolonged Effects of Angiotensin II on Renal Hemodynamics

Hypertension ◽  
1996 ◽  
Vol 27 (5) ◽  
pp. 1173-1179 ◽  
Author(s):  
Xiaolin Deng ◽  
William J. Welch ◽  
Christopher S. Wilcox
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Renal Hemodynamics ◽  
Short Term

Materials for Well Integrity: Characterization of Short-Term Mechanical Properties

2020 ◽  
Author(s):  
Mohammadreza Kamali ◽  
Mahmoud Khalifeh ◽  
Arild Saasen ◽  
Laurent Delabroy
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Compressive Strength ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Strength Reduction ◽  
Indirect Tensile Strength ◽  
Short Term ◽  
Indirect Tensile ◽  
Expansive Cement

Abstract Integrated zonal isolation is well-known as a key parameter for safe drilling operation and well completion of oil and gas wells. An extensive research on alternative materials has been conducted in the past concerning primary cementing, overcoming annular leaks, and permanent well abandonment. The present article focuses on geopolymers, expansive cement, pozzolan based sealant and thermosetting resins. The viscous behavior and the pumpability of the different materials have been investigated and benchmarked with the properties of neat class G Portland cement. The current study includes short-term mechanical properties of the above-mentioned materials. These properties include compressive strength development, Young’s modulus, indirect tensile strength, and sonic strength. The tests are performed in accordance with API 10B-2 and ASTM D3967-16 for all the materials for 1, 3, 5, and 7-day of curing at 90°C and elevated (172 bar) and atmospheric pressures. Our results show a mixed behavior from the materials. According to uniaxial compressive test results, all the candidate barrier materials developed strength during the considered period; however, the geopolymer and pozzolanic-based mixture did not develop early strength. The expansive cement showed an acceptable early compressive strength, but strength reduction was noticed after some time. The strength reduction of expansive cement was also observed for the indirect tensile strength. All the materials become stiffer overtime as they made more strength. For the neat class G cement and expansive cement, the Young’s modulus showed a minimum after 5 days, but it was increased.

scholarly journals Microtubules regulate cardiomyocyte transversal Young’s modulus

2020 ◽  
Vol 117 (6) ◽  
pp. 2764-2766 ◽  
Author(s):  
Pamela Swiatlowska ◽  
Jose L. Sanchez-Alonso ◽  
Peter T. Wright ◽  
Pavel Novak ◽  
Julia Gorelik
Keyword(s):  
Young’S Modulus ◽  
Mechanical Loading ◽  
Posttranslational Modifications ◽  
Young's Modulus ◽  
Cardiac Mechanics ◽  
Ion Conductance ◽  
Loading And Unloading ◽  
Microtubular Network ◽  
Significant Attention

The field of cardiomyocyte mechanobiology is gaining significant attention, due to accumulating evidence concerning the significant role of cellular mechanical effects on the integrated function of the heart. To date, the protein titin has been demonstrated as a major contributor to the cardiomyocytes Young’s modulus (YM). The microtubular network represents another potential regulator of cardiac mechanics. However, the contribution of microtubules (MTs) to the membrane YM is still understudied and has not been interrogated in the context of myocardial infarction (MI) or mechanical loading and unloading. Using nanoscale mechanoscanning ion conductance microscopy, we demonstrate that MTs contribute to cardiomyocyte transverse YM in healthy and pathological states with different mechanical loading. Specifically, we show that posttranslational modifications of MTs have differing effects on cardiomyocyte YM: Acetylation provides flexibility, whereas detyrosination imparts rigidity. Further studies demonstrate that there is no correlation between the total protein amount of acetylated and detyrosinated MT. Yet, in the polymerized-only populations, an increased level of acetylation results in a decline of detyrosinated MTs in an MI model.

scholarly journals Role of Corneal Epithelium in Riboflavin/Ultraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Xiangchen Tao ◽  
Haiqun Yu ◽  
Yong Zhang ◽  
Zhiwei Li ◽  
Vishal Jhanji ◽  
...  
Keyword(s):  
Young’S Modulus ◽  
Corneal Epithelium ◽  
Young's Modulus ◽  
Biomechanical Properties ◽  
Cross Linking ◽  
Control Group ◽  
Ultraviolet A ◽  
Uva Irradiation ◽  
Maximal Stress

Purpose. To evaluate the role of corneal epithelium in riboflavin/ultraviolet-A (UVA) mediated corneal collagen cross-linking treatment.Methods. Fifty New Zealand rabbits were divided into 5 groups: UVA treatment with or without corneal epithelium, UVA+riboflavin treatment with or without corneal epithelium, and control without any treatment. All rabbits were sacrificed after irradiation and subsequently 4 mm × 10 mm corneal strips were harvested for biomechanical evaluation.Results. UVA irradiation alone did not enhance the maximal stress and Young’s modulus of corneal specimens with (3.15 ± 0.56 mpa, 1.00 ± 0.09 mpa) or without (3.53 ± 0.85 mpa, 0.94 ± 0.21 mpa) the corneal epithelium, compared to specimens in the control group (4.30 ± 0.68 mpa, 1.03 ± 0.24 mpa). However, UVA irradiation combined with riboflavin significantly increased the maximal stress and Young’s modulus of corneal specimens with (5.27 ± 1.09 mpa, 1.23 ± 0.23 mpa,P<0.05) or without (7.16 ± 1.88 mpa, 1.42 ± 0.16 mpa,P<0.05) corneal epithelium when compared to the control group. The maximal stress and Young’s modulus of cornea in UVA+riboflavin and “epithelium-off” group were 35.9% and 15.4% higher compared to the UVA+riboflavin and “epithelium-on” group, respectively (P<0.05).Conclusions. Our study shows that UVA+riboflavin treatment significantly affects the biomechanical properties of the cornea with and without epithelial removal. However, corneas without epithelium seem to benefit more compared to corneas with the epithelium.

Young’s Modulus of Cortical and P19 Derived Neurons Measured by Atomic Force Microscopy

2012 ◽  
Vol 1420 ◽  
Author(s):  
Elise Spedden ◽  
James D. White ◽  
David Kaplan ◽  
Cristian Staii
Keyword(s):  
Young’S Modulus ◽  
Cortical Neurons ◽  
Young's Modulus ◽  
Neuronal Cell ◽  
Short Term ◽  
Force Microscopy ◽  
Protein Substrates ◽  
Atomic Force ◽  
Neuronal Cell Bodies ◽  
Bulk Tissue

ABSTRACTIn this paper we use the Atomic Force Microscope to measure the Young’s modulus for two types of neuronal cell bodies: cortical neurons obtained from rat embryos and neurons derived from P19 mouse embryonic carcinoma stem cells. The neurons are plated on different substrates coated with two types of protein growth factors, poly-D-lysine and laminin. We report on the Young’s modulus of each type of neuron as well as the variation of modulus between cells plated on different protein substrates. We compare these results to various individual cell and bulk tissue measurements reported in literature. We additionally report on an observed change in the Young’s modulus of cortical neurons when subjected to a short-term reduction in ambient temperature.

Capillary forces between rigid spheres and elastic supports: the role of Young's modulus and equilibrium vapor adsorption

Soft Matter ◽  
2013 ◽  
Vol 9 (17) ◽  
pp. 4534 ◽  
Author(s):  
Marjan Zakerin ◽  
Michael Kappl ◽  
Ellen H. G. Backus ◽  
Hans-Jürgen Butt ◽  
Friedhelm Schönfeld
Keyword(s):  
Young’S Modulus ◽  
Young's Modulus ◽  
Capillary Forces ◽  
Rigid Spheres ◽  
Elastic Supports ◽  
Vapor Adsorption

Effect of Porosity on Compressive Properities of Porous Titanium with Helical Pores Structure

2014 ◽  
Vol 1004-1005 ◽  
pp. 1137-1140
Author(s):  
Yan Fei Sui ◽  
Chun Ming Zou ◽  
Ying Qiao Tang ◽  
Hong Wei Wang ◽  
Zun Jie Wei
Keyword(s):  
Yield Strength ◽  
Young’S Modulus ◽  
Fiber Diameter ◽  
Young's Modulus ◽  
Functional Expression ◽  
Porous Titanium ◽  
Compressive Yield Strength ◽  
Screw Diameter ◽  
Screw Pitch

The role of pores structure in porous titanium with helical pores was studied. The results showed that porosity of porous titanium depends on diameter of titanium fiber (d1), screw diameter (d2) and screw pitch (d3). With the increase of titanium fiber diameter, the decrease of screw diameter and screw pitch, the porosity of porous titanium decreases. Compressive yield strength and Young’s modulus increase with the decrease of porosity, and the final functional expression of compressive yield strength and Young’s modulus depending on porosity was given.

Electrospun Gelatin/Hydroxyapatite Nanocomposite Scaffolds for Bone Tissue Engineering

2008 ◽  
Vol 1094 ◽  
Author(s):  
Shane Catledge ◽  
Parul Tyagi ◽  
Mark Koopman ◽  
Andrei Stanishevsky ◽  
Yogesh K. Vohra
Keyword(s):  
Young’S Modulus ◽  
Young's Modulus ◽  
Fibrous Composite ◽  
X Ray Diffraction ◽  
Composite Scaffolds ◽  
X Ray ◽  
Structure And Morphology ◽  
Electrospun Gelatin ◽  
Nanocomposite Scaffolds ◽  
Nanoscale Level

AbstractElectrospun composite scaffolds were prepared by mixing gelatin with nanoparticles of hydroxyapatite (nanoHA) in 2,2,2-trifluoroethanol (TFE) solution. The fibrous composite scaffolds with nanoHA content from 0 to 40 wt% were compared in terms of structure and morphology via x-ray diffraction (XRD) and scanning electron microscopy (SEM). Results show that dispersion of nanoHA in the scaffolds is uniform for 0%, 10%, 20%, and 30% nanoHA content, but significant nanoHA agglomeration can be observed for scaffolds with 40% nanoHA. In order to study the effect of nanoHA content on mechanical properties at the nanoscale level, the fibrous scaffolds were pressed into dense pellets and tested by nanoindentation to determine Young's modulus. Young's modulus was found to increase linearly with nanoHA content, reaching unexpectedly high values of 10.2 ± 0.8 GPa. Results are compared with other polymer/HA composites including those made with polycaprolactone or collagen.

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