Capillary forces between rigid spheres and elastic supports: the role of Young's modulus and equilibrium vapor adsorption

Soft Matter ◽  
2013 ◽  
Vol 9 (17) ◽  
pp. 4534 ◽  
Author(s):  
Marjan Zakerin ◽  
Michael Kappl ◽  
Ellen H. G. Backus ◽  
Hans-Jürgen Butt ◽  
Friedhelm Schönfeld
Keyword(s):  
Young’S Modulus ◽  
Young's Modulus ◽  
Capillary Forces ◽  
Rigid Spheres ◽  
Elastic Supports ◽  
Vapor Adsorption

scholarly journals Microtubules regulate cardiomyocyte transversal Young’s modulus

2020 ◽  
Vol 117 (6) ◽  
pp. 2764-2766 ◽  
Author(s):  
Pamela Swiatlowska ◽  
Jose L. Sanchez-Alonso ◽  
Peter T. Wright ◽  
Pavel Novak ◽  
Julia Gorelik
Keyword(s):  
Young’S Modulus ◽  
Mechanical Loading ◽  
Posttranslational Modifications ◽  
Young's Modulus ◽  
Cardiac Mechanics ◽  
Ion Conductance ◽  
Loading And Unloading ◽  
Microtubular Network ◽  
Significant Attention

The field of cardiomyocyte mechanobiology is gaining significant attention, due to accumulating evidence concerning the significant role of cellular mechanical effects on the integrated function of the heart. To date, the protein titin has been demonstrated as a major contributor to the cardiomyocytes Young’s modulus (YM). The microtubular network represents another potential regulator of cardiac mechanics. However, the contribution of microtubules (MTs) to the membrane YM is still understudied and has not been interrogated in the context of myocardial infarction (MI) or mechanical loading and unloading. Using nanoscale mechanoscanning ion conductance microscopy, we demonstrate that MTs contribute to cardiomyocyte transverse YM in healthy and pathological states with different mechanical loading. Specifically, we show that posttranslational modifications of MTs have differing effects on cardiomyocyte YM: Acetylation provides flexibility, whereas detyrosination imparts rigidity. Further studies demonstrate that there is no correlation between the total protein amount of acetylated and detyrosinated MT. Yet, in the polymerized-only populations, an increased level of acetylation results in a decline of detyrosinated MTs in an MI model.

scholarly journals Short-term angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16315-16329
Author(s):  
Pamela Swiatlowska ◽  
Jose L. Sanchez-Alonso ◽  
Catherine Mansfield ◽  
Denis Scaini ◽  
Yuri Korchev ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Short Term ◽  
Nanoscale Level

MechanoSICM is used to understand the role of angiotensin II on transverse Young's modulus at the nanoscale level.

scholarly journals Role of Corneal Epithelium in Riboflavin/Ultraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Xiangchen Tao ◽  
Haiqun Yu ◽  
Yong Zhang ◽  
Zhiwei Li ◽  
Vishal Jhanji ◽  
...  
Keyword(s):  
Young’S Modulus ◽  
Corneal Epithelium ◽  
Young's Modulus ◽  
Biomechanical Properties ◽  
Cross Linking ◽  
Control Group ◽  
Ultraviolet A ◽  
Uva Irradiation ◽  
Maximal Stress

Purpose. To evaluate the role of corneal epithelium in riboflavin/ultraviolet-A (UVA) mediated corneal collagen cross-linking treatment.Methods. Fifty New Zealand rabbits were divided into 5 groups: UVA treatment with or without corneal epithelium, UVA+riboflavin treatment with or without corneal epithelium, and control without any treatment. All rabbits were sacrificed after irradiation and subsequently 4 mm × 10 mm corneal strips were harvested for biomechanical evaluation.Results. UVA irradiation alone did not enhance the maximal stress and Young’s modulus of corneal specimens with (3.15 ± 0.56 mpa, 1.00 ± 0.09 mpa) or without (3.53 ± 0.85 mpa, 0.94 ± 0.21 mpa) the corneal epithelium, compared to specimens in the control group (4.30 ± 0.68 mpa, 1.03 ± 0.24 mpa). However, UVA irradiation combined with riboflavin significantly increased the maximal stress and Young’s modulus of corneal specimens with (5.27 ± 1.09 mpa, 1.23 ± 0.23 mpa,P<0.05) or without (7.16 ± 1.88 mpa, 1.42 ± 0.16 mpa,P<0.05) corneal epithelium when compared to the control group. The maximal stress and Young’s modulus of cornea in UVA+riboflavin and “epithelium-off” group were 35.9% and 15.4% higher compared to the UVA+riboflavin and “epithelium-on” group, respectively (P<0.05).Conclusions. Our study shows that UVA+riboflavin treatment significantly affects the biomechanical properties of the cornea with and without epithelial removal. However, corneas without epithelium seem to benefit more compared to corneas with the epithelium.

Effect of Porosity on Compressive Properities of Porous Titanium with Helical Pores Structure

2014 ◽  
Vol 1004-1005 ◽  
pp. 1137-1140
Author(s):  
Yan Fei Sui ◽  
Chun Ming Zou ◽  
Ying Qiao Tang ◽  
Hong Wei Wang ◽  
Zun Jie Wei
Keyword(s):  
Yield Strength ◽  
Young’S Modulus ◽  
Fiber Diameter ◽  
Young's Modulus ◽  
Functional Expression ◽  
Porous Titanium ◽  
Compressive Yield Strength ◽  
Screw Diameter ◽  
Screw Pitch

The role of pores structure in porous titanium with helical pores was studied. The results showed that porosity of porous titanium depends on diameter of titanium fiber (d1), screw diameter (d2) and screw pitch (d3). With the increase of titanium fiber diameter, the decrease of screw diameter and screw pitch, the porosity of porous titanium decreases. Compressive yield strength and Young’s modulus increase with the decrease of porosity, and the final functional expression of compressive yield strength and Young’s modulus depending on porosity was given.

scholarly journals Effect of Electrospun Fiber Mat Thickness and Support Method on Cell Morphology

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 644 ◽  
Author(s):  
Mark A. Calhoun ◽  
Sadiyah Sabah Chowdhury ◽  
Mark Tyler Nelson ◽  
John J. Lannutti ◽  
Rebecca B. Dupaix ◽  
...  
Keyword(s):  
Young’S Modulus ◽  
Mechanical Response ◽  
Young's Modulus ◽  
Electrospun Fiber ◽  
Cell Spreading ◽  
Cell Polarization ◽  
Fiber Mats ◽  
Inner Diameter ◽  
Mat Thickness

Electrospun fiber mats (EFMs) are highly versatile biomaterials used in a myriad of biomedical applications. Whereas some facets of EFMs are well studied and can be highly tuned (e.g., pore size, fiber diameter, etc.), other features are under characterized. For example, although substrate mechanics have been explored by several groups, most studies rely on Young’s modulus alone as a characterization variable. The influence of fiber mat thickness and the effect of supports are variables that are often not considered when evaluating cell-mechanical response. To assay the role of these features in EFM scaffold design and to improve understanding of scaffold mechanical properties, we designed EFM scaffolds with varying thickness (50–200 µm) and supporting methodologies. EFM scaffolds were comprised of polycaprolactone and were either electrospun directly onto a support, suspended across an annulus (3 or 10 mm inner diameter), or “tension-released” and then suspended across an annulus. Then, single cell spreading (i.e., Feret diameter) was measured in the presence of these different features. Cells were sensitive to EFM thickness and suspended gap diameter. Overall, cell spreading was greatest for 50 µm thick EFMs suspended over a 3 mm gap, which was the smallest thickness and gap investigated. These results are counterintuitive to conventional understanding in mechanobiology, which suggests that stiffer materials, such as thicker, supported EFMs, should elicit greater cell polarization. Additional experiments with 50 µm thick EFMs on polystyrene and polydimethylsiloxane (PDMS) supports demonstrated that cells can “feel” the support underlying the EFM if it is rigid, similar to previous results in hydrogels. These results also suggest that EFM curvature may play a role in cell response, separate from Young’s modulus, possibly because of internal tension generated. These parameters are not often considered in EFM design and could improve scaffold performance and ultimately patient outcomes.

scholarly journals Anisotropy of Mechanical Properties and Residual Stress in Additively Manufactured 316L Specimens

Materials ◽  
2021 ◽  
Vol 14 (23) ◽  
pp. 7176
Author(s):  
Alexey Fedorenko ◽  
Boris Fedulov ◽  
Yulia Kuzminova ◽  
Stanislav Evlashin ◽  
Oleg Staroverov ◽  
...  
Keyword(s):  
Residual Stress ◽  
Tensile Test ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Mechanical Test ◽  
Test Methods ◽  
Test Results ◽  
Initial Stage ◽  
Anisotropy Of Mechanical Properties

In the presented study, LPBF 316L stainless steel tensile specimens were manufactured in three different orientations for the analysis of anisotropy. The first set of specimens was built vertically on the build platform, and two other sets were oriented horizontally perpendicular to each other. Tensile test results show that mean Young’s modulus of vertically built specimens is significantly less then horizontal ones (158.7 GPa versus 198 GPa), as well as yield strength and elongation. A role of residual stress in a deviation of tensile loading diagrams is investigated as a possible explanation. Simulation of the build process on the basis of ABAQUS FEA software was used to predict residual stress in 316L cylindrical specimens. Virtual tensile test results show that residual stress affects the initial stage of the loading curve with a tendency to reduce apparent Young’s modulus, measured according to standard mechanical test methods.

The Role of Precipitates in the Behavior of Young’s Modulus in Aluminum Alloys

2014 ◽  
Vol 45 (9) ◽  
pp. 3857-3865 ◽  
Author(s):  
Aranzazu Villuendas ◽  
Jordi Jorba ◽  
Antoni Roca
Keyword(s):  
Aluminum Alloys ◽  
Young’S Modulus ◽  
Young's Modulus
Sign in / Sign up

Export Citation Format

Share Document