Cobalt carbide-based theranostic agents for in vivo multimodal imaging guided photothermal therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7174-7179
Author(s):  
Dong-Yang Zhang ◽  
Han Xu ◽  
Ting He ◽  
Muhammad Rizwan Younis ◽  
Leli Zeng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Cobalt Carbide ◽  
Theranostic Agents

Cobalt carbide-based theranostic agents were developed for magnetic resonance/photoacoustic/photothermal multimodal imaging guided photothermal therapy of cancer.

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

scholarly journals On/off switchable epicatechin-based ultra-sensitive MRI-visible nanotheranostics – see it and treat it

2020 ◽  
Vol 8 (18) ◽  
pp. 5210-5218
Author(s):  
Bing Xiao ◽  
Xiaoxuan Zhou ◽  
Hongxia Xu ◽  
Wei Zhang ◽  
Xiaodan Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Theranostic Agents

Renal-clearable polyphenol/MnO2 hybrid theranostic agents for multifunctional MRI and photothermal therapy (PTT) in vivo.

A polydopamine-coated LAPONITE®-stabilized iron oxide nanoplatform for targeted multimodal imaging-guided photothermal cancer therapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3856-3864 ◽  
Author(s):  
Mengxue Liu ◽  
Jiulong Zhang ◽  
Xin Li ◽  
Chao Cai ◽  
Xueyan Cao ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Sialic Acid ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Photoacoustic Imaging

A novel targeted theranostic nanoplatform (LAP–Fe3O4@PDA–PEG–PBA) is constructed for magnetic resonance and photoacoustic imaging-guided photothermal therapy of cancer cells overexpressing sialic acid.

scholarly journals Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging

2010 ◽  
Vol 46 (21) ◽  
pp. 3705 ◽  
Author(s):  
Kevin Guo ◽  
Mikhail Y. Berezin ◽  
Jie Zheng ◽  
Walter Akers ◽  
Franck Lin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Molecular Probe ◽  
Resonance Imaging

A mesoporous polydopamine nanoparticle enables highly efficient manganese encapsulation for enhanced MRI-guided photothermal therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yan Wu ◽  
Yu Huang ◽  
Chunlai Tu ◽  
Fengren Wu ◽  
Gangsheng Tong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Highly Efficient ◽  
Enhanced Mri ◽  
Mri Guided ◽  
Theranostic Agents ◽  
Magnetic Resonance Imaging Mri

Theranostic agents based on magnetic resonance imaging (MRI) and photothermal therapy (PTT) play an important role in tumor therapy. However, available theranostic agents are confronting great challenges in the issues...

scholarly journals Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Quan Tao ◽  
Genghan He ◽  
Sheng Ye ◽  
Di Zhang ◽  
Zhide Zhang ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Fenton Reaction ◽  
Infrared Range ◽  
Prussian Blue Nanoparticles ◽  
Mild Temperature ◽  
Mn Doped

Abstract Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstract

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (11) ◽  
pp. 10245-10257 ◽  
Author(s):  
Weitao Yang ◽  
Weisheng Guo ◽  
Wenjun Le ◽  
Guoxian Lv ◽  
Fuhe Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Resonance Imaging
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