Highly Efficient, Conjugated-Polymer-Based Nano-Photosensitizers for Selectively Targeted Two-Photon Photodynamic Therapy and Imaging of Cancer Cells

2014 ◽  
Vol 21 (5) ◽  
pp. 2214-2221 ◽  
Author(s):  
Xiaoqin Shen ◽  
Shuang Li ◽  
Lin Li ◽  
Shao Q. Yao ◽  
Qing-Hua Xu
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Conjugated Polymer ◽  
Two Photon ◽  
Highly Efficient

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

A two-photon AIE fluorophore as a photosensitizer for highly efficient mitochondria-targeted photodynamic therapy

2020 ◽  
Vol 44 (22) ◽  
pp. 9355-9364 ◽  
Author(s):  
Qunshou Kong ◽  
Boxuan Ma ◽  
Tao Yu ◽  
Cheng Hu ◽  
Gaocan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

Nowadays, photodynamic therapy (PDT) has become an effective method for cancer therapy.

scholarly journals Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

2019 ◽  
Vol 55 (81) ◽  
pp. 12231-12234 ◽  
Author(s):  
Limiao Shi ◽  
Christophe Nguyen ◽  
Morgane Daurat ◽  
Abdelhamid Chiheb Dhieb ◽  
Wajda Smirani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Breast Cancer Cells ◽  
Two Photon ◽  
Theranostic Applications

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.

ROS-Responsive and active targeted drug delivery based on conjugated polymer nanoparticles for synergistic chemo-/photodynamic therapy

2021 ◽  
Author(s):  
Ziqi Zhang ◽  
Zhuanning Lu ◽  
Qiong Yuan ◽  
Chen Zhang ◽  
Yanli Tang
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Targeted Drug Delivery ◽  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Active Targeting ◽  
Highly Efficient ◽  
Conjugated Polymer Nanoparticles ◽  
Targeted Drug

A biocompatible and ROS-responsive drug delivery nanocarrier iRGD-BDOX@CPNs with active targeting was constructed for highly efficient chemo-/photodynamic (PDT) synergistic therapy.

scholarly journals Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

2016 ◽  
Vol 23 (2) ◽  
pp. 234-238 ◽  
Author(s):  
Luke K. McKenzie ◽  
Igor V. Sazanovich ◽  
Elizabeth Baggaley ◽  
Mickaële Bonneau ◽  
Véronique Guerchais ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Iridium Complex ◽  
Two Photon ◽  
Near Ir ◽  
Ir Light

Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells

2016 ◽  
Vol 4 (33) ◽  
pp. 5567-5574 ◽  
Author(s):  
Jonas G. Croissant ◽  
Sébastien Picard ◽  
Dina Aggad ◽  
Maxime Klausen ◽  
Chiara Mauriello Jimenez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Click Chemistry ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Periodic Mesoporous Organosilica ◽  
Two Photon ◽  
Mesoporous Organosilica ◽  
Photon Imaging ◽  
In Cells

The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described.

A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability

2021 ◽  
Author(s):  
Yan-Qin Huang ◽  
Shan-Shan Jiang ◽  
Li-Xiang Pan ◽  
Rui Zhang ◽  
Kun-Lin Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
High Resistance ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Oxygen Production ◽  
Nonspecific Binding ◽  
Two Photon

Water-soluble conjugated polymers (WSCPs) with dual capability of two-photon imaging and singlet oxygen (1O2) production have become one type of the most promising agents in noninvasive imaging guided photodynamic therapy...

An AceDAN–porphyrin(Zn) dyad for fluorescence imaging and photodynamic therapy via two-photon excited FRET

2018 ◽  
Vol 5 (12) ◽  
pp. 3061-3066 ◽  
Author(s):  
Mengliang Zhu ◽  
Chaorui Su ◽  
Peipei Xing ◽  
Yabin Zhou ◽  
Lei Gong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Red Emission ◽  
Two Photon

A FRET based AceDAN–porphyrin(Zn) dyad was designed to generate red emission and singlet oxygen (1O2) simultaneously, which were utilized successfully for two-photon excited fluorescence imaging and PDT of cancer cells.

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